Abstract
Purpose: To investigate whether ultrasonographic (US) features of thyroid nodules are associated with tumor recurrence in classic papillary thyroid carcinoma (PTC). Materials and Methods: This retrospective study was approved by the Institutional Review Board, and the need to obtain informed consent was waived. A total of 515 patients (mean age, 45.8 years ± 13.2 [standard deviation]; range, 17-80 years) who underwent total thyroidectomy and central lymph node dissection for classic PTC greater than 10 mm from January 2003 to February 2006 and who were followed up for 12 months or longer were included. Malignant-appearing PTCs were defined as those showing at least one suspicious US feature among marked hypoechogenicity, irregular or microlobulated margin, microcalcifications, and taller-than-wide shape. Benign-appearing PTCs were defined as those without any suspicious US features. Kaplan-Meier cumulative-event curves for recurrence were compared by using the log-rank test. The multivariate Cox proportional hazard regression analysis was used to estimate hazard ratios (HRs) of the malignant-appearing US features for recurrence in the preoperative, postoperative, and combined models. Results: Fifty-six (10.9%) of 515 patients had recurrence. Malignant-appearing PTCs had lower 5-and 10-year diseasefree survival rates compared with benign-appearing PTCs (P =.01). In the preoperative model, malignant-appearing US features (HR, 3.523; 95% confidence interval [CI]: 1.263, 9.830) and larger nodule size (HR, 1.074; 95% CI: 1.051, 1.098) were independently associated with recurrence. In the combined model, male sex (HR, 1.990; 95% CI: 1.098, 3.610), malignant-appearing US features (HR, 2.828; 95% CI: 1.016. 7.870), larger nodule size (HR, 1.067; 95% CI: 1.043, 1.092), extrathyroidal extension (HR, 2.590; 95% CI: 1.160, 5.780), and lymph node metastasis (HR, 2.511; 95% CI: 1.163, 5.421) were independently associated with recurrence. Conclusion: The presence of malignant-appearing US features was independently associated with recurrence in patients with classic PTC.
| Original language | English |
|---|---|
| Pages (from-to) | 574-583 |
| Number of pages | 10 |
| Journal | Radiology |
| Volume | 277 |
| Issue number | 2 |
| DOIs | |
| Publication status | Published - 2015 Jan 1 |
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All Science Journal Classification (ASJC) codes
- Radiology Nuclear Medicine and imaging
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Association of preoperative US features and recurrence in patients with classic papillary thyroid carcinoma. / Kim, Soo Yeon; kwak, jinyoung; Kim, Eunkyung; Yoon, Jung Hyun; Moon, Hee Jung.
In: Radiology, Vol. 277, No. 2, 01.01.2015, p. 574-583.Research output: Contribution to journal › Article
TY - JOUR
T1 - Association of preoperative US features and recurrence in patients with classic papillary thyroid carcinoma
AU - Kim, Soo Yeon
AU - kwak, jinyoung
AU - Kim, Eunkyung
AU - Yoon, Jung Hyun
AU - Moon, Hee Jung
PY - 2015/1/1
Y1 - 2015/1/1
N2 - Purpose: To investigate whether ultrasonographic (US) features of thyroid nodules are associated with tumor recurrence in classic papillary thyroid carcinoma (PTC). Materials and Methods: This retrospective study was approved by the Institutional Review Board, and the need to obtain informed consent was waived. A total of 515 patients (mean age, 45.8 years ± 13.2 [standard deviation]; range, 17-80 years) who underwent total thyroidectomy and central lymph node dissection for classic PTC greater than 10 mm from January 2003 to February 2006 and who were followed up for 12 months or longer were included. Malignant-appearing PTCs were defined as those showing at least one suspicious US feature among marked hypoechogenicity, irregular or microlobulated margin, microcalcifications, and taller-than-wide shape. Benign-appearing PTCs were defined as those without any suspicious US features. Kaplan-Meier cumulative-event curves for recurrence were compared by using the log-rank test. The multivariate Cox proportional hazard regression analysis was used to estimate hazard ratios (HRs) of the malignant-appearing US features for recurrence in the preoperative, postoperative, and combined models. Results: Fifty-six (10.9%) of 515 patients had recurrence. Malignant-appearing PTCs had lower 5-and 10-year diseasefree survival rates compared with benign-appearing PTCs (P =.01). In the preoperative model, malignant-appearing US features (HR, 3.523; 95% confidence interval [CI]: 1.263, 9.830) and larger nodule size (HR, 1.074; 95% CI: 1.051, 1.098) were independently associated with recurrence. In the combined model, male sex (HR, 1.990; 95% CI: 1.098, 3.610), malignant-appearing US features (HR, 2.828; 95% CI: 1.016. 7.870), larger nodule size (HR, 1.067; 95% CI: 1.043, 1.092), extrathyroidal extension (HR, 2.590; 95% CI: 1.160, 5.780), and lymph node metastasis (HR, 2.511; 95% CI: 1.163, 5.421) were independently associated with recurrence. Conclusion: The presence of malignant-appearing US features was independently associated with recurrence in patients with classic PTC.
AB - Purpose: To investigate whether ultrasonographic (US) features of thyroid nodules are associated with tumor recurrence in classic papillary thyroid carcinoma (PTC). Materials and Methods: This retrospective study was approved by the Institutional Review Board, and the need to obtain informed consent was waived. A total of 515 patients (mean age, 45.8 years ± 13.2 [standard deviation]; range, 17-80 years) who underwent total thyroidectomy and central lymph node dissection for classic PTC greater than 10 mm from January 2003 to February 2006 and who were followed up for 12 months or longer were included. Malignant-appearing PTCs were defined as those showing at least one suspicious US feature among marked hypoechogenicity, irregular or microlobulated margin, microcalcifications, and taller-than-wide shape. Benign-appearing PTCs were defined as those without any suspicious US features. Kaplan-Meier cumulative-event curves for recurrence were compared by using the log-rank test. The multivariate Cox proportional hazard regression analysis was used to estimate hazard ratios (HRs) of the malignant-appearing US features for recurrence in the preoperative, postoperative, and combined models. Results: Fifty-six (10.9%) of 515 patients had recurrence. Malignant-appearing PTCs had lower 5-and 10-year diseasefree survival rates compared with benign-appearing PTCs (P =.01). In the preoperative model, malignant-appearing US features (HR, 3.523; 95% confidence interval [CI]: 1.263, 9.830) and larger nodule size (HR, 1.074; 95% CI: 1.051, 1.098) were independently associated with recurrence. In the combined model, male sex (HR, 1.990; 95% CI: 1.098, 3.610), malignant-appearing US features (HR, 2.828; 95% CI: 1.016. 7.870), larger nodule size (HR, 1.067; 95% CI: 1.043, 1.092), extrathyroidal extension (HR, 2.590; 95% CI: 1.160, 5.780), and lymph node metastasis (HR, 2.511; 95% CI: 1.163, 5.421) were independently associated with recurrence. Conclusion: The presence of malignant-appearing US features was independently associated with recurrence in patients with classic PTC.
UR - http://www.scopus.com/inward/record.url?scp=84946052877&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84946052877&partnerID=8YFLogxK
U2 - 10.1148/radiol.2015142470
DO - 10.1148/radiol.2015142470
M3 - Article
C2 - 25955580
AN - SCOPUS:84946052877
VL - 277
SP - 574
EP - 583
JO - Radiology
JF - Radiology
SN - 0033-8419
IS - 2
ER -