Association of RAGE gene polymorphisms with in-stent restenosis in non-diabetic Korean population

Chi Young Shim, Sungha Park, Se Jung Yoon, Hyun Young Park, Hung Tae Kim, Bermseok Oh, Chanmi Park, Young Guk Ko, Donghoon Choi, Yangsoo Jang, Namsik Chung

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Backgrounds: Interaction between advanced glycosylation end products (AGEs) and receptor for AGEs (RAGE) in vessel wall may lead to inflammation, smooth muscle cell proliferation, and extracellular matrix production, culminating in exaggerated intimal hyperplasia and restenosis. We investigated the possibility that single nucleotide polymorphisms of the genes encoding RAGE are associated with in-stent restenosis after coronary stenting. Methods: Our study included 334 consecutive non-diabetic male patients with symptomatic coronary artery disease who underwent bare metal stent implantation. Follow-up angiography was performed in 297 patients (88.9%), 6 months after intervention. We screened -1106T→C, -443T→C, -388T→A, -257G→A, +557G→A and +1704G→T RAGE polymorphisms in these patients. Genotyping was performed by single base extension with amplifying primers and probes for TaqMan. Results: A total of 355 target lesions were evaluated, in 297 patients. There was no significant association of the -1106T→C, -443T→C, -388T→A, -257G→A, +557G→A or +1704G→T polymorphisms with in-stent restenosis after coronary artery stenting. We did not observe a significant difference between the genotype distributions and the rates of angiographic restenosis between the polymorphisms. In a multivariate analysis of angiographic restenosis, we examined the possible influence of the baseline, lesion-related, and procedural variables. After adjustment for these potentially confounding factors, the multivariate analysis did not reveal an association of polymorphism with angiographic restenosis. Conclusion: Our observation suggests that the RAGE gene polymorphism is not associated with in-stent restenosis after coronary artery stenting in non-diabetic patients in the Korean population.

Original languageEnglish
Pages (from-to)261-268
Number of pages8
JournalCardiology
Volume107
Issue number4
DOIs
Publication statusPublished - 2007 May 1

Fingerprint

Stents
Population
Genes
Coronary Vessels
Multivariate Analysis
Coronary Restenosis
Tunica Intima
Statistical Factor Analysis
Smooth Muscle Myocytes
Hyperplasia
Single Nucleotide Polymorphism
Extracellular Matrix
Coronary Artery Disease
Angiography
Metals
Genotype
Cell Proliferation
Observation
Advanced Glycosylation End Product-Specific Receptor
Inflammation

All Science Journal Classification (ASJC) codes

  • Cardiology and Cardiovascular Medicine
  • Pharmacology (medical)

Cite this

Shim, Chi Young ; Park, Sungha ; Yoon, Se Jung ; Park, Hyun Young ; Kim, Hung Tae ; Oh, Bermseok ; Park, Chanmi ; Ko, Young Guk ; Choi, Donghoon ; Jang, Yangsoo ; Chung, Namsik. / Association of RAGE gene polymorphisms with in-stent restenosis in non-diabetic Korean population. In: Cardiology. 2007 ; Vol. 107, No. 4. pp. 261-268.
@article{58cf45deb660458498aa1c132c6f5f56,
title = "Association of RAGE gene polymorphisms with in-stent restenosis in non-diabetic Korean population",
abstract = "Backgrounds: Interaction between advanced glycosylation end products (AGEs) and receptor for AGEs (RAGE) in vessel wall may lead to inflammation, smooth muscle cell proliferation, and extracellular matrix production, culminating in exaggerated intimal hyperplasia and restenosis. We investigated the possibility that single nucleotide polymorphisms of the genes encoding RAGE are associated with in-stent restenosis after coronary stenting. Methods: Our study included 334 consecutive non-diabetic male patients with symptomatic coronary artery disease who underwent bare metal stent implantation. Follow-up angiography was performed in 297 patients (88.9{\%}), 6 months after intervention. We screened -1106T→C, -443T→C, -388T→A, -257G→A, +557G→A and +1704G→T RAGE polymorphisms in these patients. Genotyping was performed by single base extension with amplifying primers and probes for TaqMan. Results: A total of 355 target lesions were evaluated, in 297 patients. There was no significant association of the -1106T→C, -443T→C, -388T→A, -257G→A, +557G→A or +1704G→T polymorphisms with in-stent restenosis after coronary artery stenting. We did not observe a significant difference between the genotype distributions and the rates of angiographic restenosis between the polymorphisms. In a multivariate analysis of angiographic restenosis, we examined the possible influence of the baseline, lesion-related, and procedural variables. After adjustment for these potentially confounding factors, the multivariate analysis did not reveal an association of polymorphism with angiographic restenosis. Conclusion: Our observation suggests that the RAGE gene polymorphism is not associated with in-stent restenosis after coronary artery stenting in non-diabetic patients in the Korean population.",
author = "Shim, {Chi Young} and Sungha Park and Yoon, {Se Jung} and Park, {Hyun Young} and Kim, {Hung Tae} and Bermseok Oh and Chanmi Park and Ko, {Young Guk} and Donghoon Choi and Yangsoo Jang and Namsik Chung",
year = "2007",
month = "5",
day = "1",
doi = "10.1159/000095516",
language = "English",
volume = "107",
pages = "261--268",
journal = "Cardiology",
issn = "0008-6312",
publisher = "S. Karger AG",
number = "4",

}

Association of RAGE gene polymorphisms with in-stent restenosis in non-diabetic Korean population. / Shim, Chi Young; Park, Sungha; Yoon, Se Jung; Park, Hyun Young; Kim, Hung Tae; Oh, Bermseok; Park, Chanmi; Ko, Young Guk; Choi, Donghoon; Jang, Yangsoo; Chung, Namsik.

In: Cardiology, Vol. 107, No. 4, 01.05.2007, p. 261-268.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Association of RAGE gene polymorphisms with in-stent restenosis in non-diabetic Korean population

AU - Shim, Chi Young

AU - Park, Sungha

AU - Yoon, Se Jung

AU - Park, Hyun Young

AU - Kim, Hung Tae

AU - Oh, Bermseok

AU - Park, Chanmi

AU - Ko, Young Guk

AU - Choi, Donghoon

AU - Jang, Yangsoo

AU - Chung, Namsik

PY - 2007/5/1

Y1 - 2007/5/1

N2 - Backgrounds: Interaction between advanced glycosylation end products (AGEs) and receptor for AGEs (RAGE) in vessel wall may lead to inflammation, smooth muscle cell proliferation, and extracellular matrix production, culminating in exaggerated intimal hyperplasia and restenosis. We investigated the possibility that single nucleotide polymorphisms of the genes encoding RAGE are associated with in-stent restenosis after coronary stenting. Methods: Our study included 334 consecutive non-diabetic male patients with symptomatic coronary artery disease who underwent bare metal stent implantation. Follow-up angiography was performed in 297 patients (88.9%), 6 months after intervention. We screened -1106T→C, -443T→C, -388T→A, -257G→A, +557G→A and +1704G→T RAGE polymorphisms in these patients. Genotyping was performed by single base extension with amplifying primers and probes for TaqMan. Results: A total of 355 target lesions were evaluated, in 297 patients. There was no significant association of the -1106T→C, -443T→C, -388T→A, -257G→A, +557G→A or +1704G→T polymorphisms with in-stent restenosis after coronary artery stenting. We did not observe a significant difference between the genotype distributions and the rates of angiographic restenosis between the polymorphisms. In a multivariate analysis of angiographic restenosis, we examined the possible influence of the baseline, lesion-related, and procedural variables. After adjustment for these potentially confounding factors, the multivariate analysis did not reveal an association of polymorphism with angiographic restenosis. Conclusion: Our observation suggests that the RAGE gene polymorphism is not associated with in-stent restenosis after coronary artery stenting in non-diabetic patients in the Korean population.

AB - Backgrounds: Interaction between advanced glycosylation end products (AGEs) and receptor for AGEs (RAGE) in vessel wall may lead to inflammation, smooth muscle cell proliferation, and extracellular matrix production, culminating in exaggerated intimal hyperplasia and restenosis. We investigated the possibility that single nucleotide polymorphisms of the genes encoding RAGE are associated with in-stent restenosis after coronary stenting. Methods: Our study included 334 consecutive non-diabetic male patients with symptomatic coronary artery disease who underwent bare metal stent implantation. Follow-up angiography was performed in 297 patients (88.9%), 6 months after intervention. We screened -1106T→C, -443T→C, -388T→A, -257G→A, +557G→A and +1704G→T RAGE polymorphisms in these patients. Genotyping was performed by single base extension with amplifying primers and probes for TaqMan. Results: A total of 355 target lesions were evaluated, in 297 patients. There was no significant association of the -1106T→C, -443T→C, -388T→A, -257G→A, +557G→A or +1704G→T polymorphisms with in-stent restenosis after coronary artery stenting. We did not observe a significant difference between the genotype distributions and the rates of angiographic restenosis between the polymorphisms. In a multivariate analysis of angiographic restenosis, we examined the possible influence of the baseline, lesion-related, and procedural variables. After adjustment for these potentially confounding factors, the multivariate analysis did not reveal an association of polymorphism with angiographic restenosis. Conclusion: Our observation suggests that the RAGE gene polymorphism is not associated with in-stent restenosis after coronary artery stenting in non-diabetic patients in the Korean population.

UR - http://www.scopus.com/inward/record.url?scp=34249042954&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=34249042954&partnerID=8YFLogxK

U2 - 10.1159/000095516

DO - 10.1159/000095516

M3 - Article

C2 - 16954682

AN - SCOPUS:34249042954

VL - 107

SP - 261

EP - 268

JO - Cardiology

JF - Cardiology

SN - 0008-6312

IS - 4

ER -