Association of Reproductive Lifespan Duration and Chronic Kidney Disease in Postmenopausal Women

Shin Chan Kang, Jong Hyun Jhee, Young Su Joo, Sang Mi Lee, Ki Heon Nam, Hae Ryong Yun, Seung Hyeok Han, Tae Hyun Yoo, Shin Wook Kang, Jung Tak Park

Research output: Contribution to journalArticlepeer-review

5 Citations (Scopus)


Objective: To investigate the relationship between endogenous estrogen exposure and renal function, the association of female reproductive life span duration (RLD) and chronic kidney disease (CKD) was analyzed in postmenopausal women. Patients and Methods: Data were retrieved from the Korean Genome and Epidemiology Study, which was constructed from May 1, 2001, through December 25, 2017. A total of 50,338 and 3155 postmenopausal women were each included in the cross-sectional and longitudinal analyses. The RLD was determined by subtracting the age at menarche from the age at menopause. Participants were grouped into RLD quartiles. Participants with estimated glomerular filtration rates less than 60 mL/min/1.73 m2 were regarded to have CKD. Results: In the cross-sectional analysis, mean ± SD age and estimated glomerular filtration rate were 56.3±4.9 years and 93.1±13.6 mL/min/1.73 m2, respectively. Mean ± SD RLD was 34.2±4.0 years. A total of 765 of 50,338 (1.52%) women were found to have CKD. Logistic regression analysis revealed that the odds ratio for CKD was lower in groups with longer RLDs as compared with the shortest RLD group. In longitudinal analysis, postmenopausal women with normal kidney function were followed up for 9.7 years and incident CKD occurred in 221 of 3155 (7.00%) participants. Cox analysis revealed that the risk for CKD development was significantly lower in longer RLD groups. This finding was significant even after adjustments for confounding factors. Conclusion: The risk for CKD was lower in women with longer RLDs. The amount of endogenous estrogen exposure could be a determining factor for renal function in postmenopausal women.

Original languageEnglish
Pages (from-to)2621-2632
Number of pages12
JournalMayo Clinic Proceedings
Issue number12
Publication statusPublished - 2020 Dec

Bibliographical note

Funding Information:
The epidemiologic data used in this study were obtained from the Korean Genome and Epidemiology Study (4851–302) of the Korea Centers for Disease Control and Prevention, Republic of Korea.

Publisher Copyright:
© 2020 Mayo Foundation for Medical Education and Research

All Science Journal Classification (ASJC) codes

  • Medicine(all)


Dive into the research topics of 'Association of Reproductive Lifespan Duration and Chronic Kidney Disease in Postmenopausal Women'. Together they form a unique fingerprint.

Cite this