Association of serum γ-glutamyltransferase with C-reactive protein levels and white blood cell count in Korean adults

Yongjae Lee, Jong Koo Kim, Jung Hyun Lee, Hye Ree Lee, Dae Ryong Kang, Jae Yong Shim

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

Background: Elevated γ-glutamyltransferase (GGT) has emerged as an independent predictor of cardiovascular disease (CVD) which is increasingly viewed as an inflammatory disease. Thus, the mechanism underlying the link between elevated GGT and CVD may be inflammation. Methods: We examined the relationship between GGT and C-reactive protein (CRP) levels and white blood cell (WBC) count in 4562 Korean adults (2104 men, 2458 women). The odds ratio (OR) and 95% confidence interval (CI) for high CRP and WBC count (≥75th percentile) for both men and women were calculated across each quartile of serum GGT. Results: Results for the OR (95% CI) for high CRP levels by GGT quartiles were 1.00, 1.67 (1.21-2.29), 2.10 (1.51-2.93) and 2.51 (1.81-3.60) in men, and 1.00, 1.05 (0.65-1.68), 1.45 (0.79-2.02) and 2.16 (1.37-3.41) in women after adjustment for age, smoking status, alcohol intake, exercise, body mass index, blood pressure, fasting plasma glucose, triglyceride, high-density lipoprotein-cholesterol, and uric acid. Similarly, positive associations between serum GGT and WBC count were also observed. Conclusions: The present study demonstrates a positive correlation between GGT and two markers of inflammation, serum CRP and WBC count. Our findings suggest that serum GGT may be a surrogate inflammatory marker and a useful additional measure in assessing cardiovascular risk.

Original languageEnglish
Pages (from-to)1410-1415
Number of pages6
JournalClinical Chemistry and Laboratory Medicine
Volume46
Issue number10
DOIs
Publication statusPublished - 2008 Oct 1

Fingerprint

Leukocyte Count
C-Reactive Protein
Blood
Cells
Serum
Cardiovascular Diseases
Odds Ratio
Confidence Intervals
Inflammation
Blood pressure
Uric Acid
HDL Cholesterol
Blood Proteins
Fasting
Triglycerides
Body Mass Index
Biomarkers
Smoking
Alcohols
Exercise

All Science Journal Classification (ASJC) codes

  • Clinical Biochemistry
  • Biochemistry, medical

Cite this

Lee, Yongjae ; Kim, Jong Koo ; Lee, Jung Hyun ; Lee, Hye Ree ; Kang, Dae Ryong ; Shim, Jae Yong. / Association of serum γ-glutamyltransferase with C-reactive protein levels and white blood cell count in Korean adults. In: Clinical Chemistry and Laboratory Medicine. 2008 ; Vol. 46, No. 10. pp. 1410-1415.
@article{4394ed8fbe99485c9c1bb4257125e692,
title = "Association of serum γ-glutamyltransferase with C-reactive protein levels and white blood cell count in Korean adults",
abstract = "Background: Elevated γ-glutamyltransferase (GGT) has emerged as an independent predictor of cardiovascular disease (CVD) which is increasingly viewed as an inflammatory disease. Thus, the mechanism underlying the link between elevated GGT and CVD may be inflammation. Methods: We examined the relationship between GGT and C-reactive protein (CRP) levels and white blood cell (WBC) count in 4562 Korean adults (2104 men, 2458 women). The odds ratio (OR) and 95{\%} confidence interval (CI) for high CRP and WBC count (≥75th percentile) for both men and women were calculated across each quartile of serum GGT. Results: Results for the OR (95{\%} CI) for high CRP levels by GGT quartiles were 1.00, 1.67 (1.21-2.29), 2.10 (1.51-2.93) and 2.51 (1.81-3.60) in men, and 1.00, 1.05 (0.65-1.68), 1.45 (0.79-2.02) and 2.16 (1.37-3.41) in women after adjustment for age, smoking status, alcohol intake, exercise, body mass index, blood pressure, fasting plasma glucose, triglyceride, high-density lipoprotein-cholesterol, and uric acid. Similarly, positive associations between serum GGT and WBC count were also observed. Conclusions: The present study demonstrates a positive correlation between GGT and two markers of inflammation, serum CRP and WBC count. Our findings suggest that serum GGT may be a surrogate inflammatory marker and a useful additional measure in assessing cardiovascular risk.",
author = "Yongjae Lee and Kim, {Jong Koo} and Lee, {Jung Hyun} and Lee, {Hye Ree} and Kang, {Dae Ryong} and Shim, {Jae Yong}",
year = "2008",
month = "10",
day = "1",
doi = "10.1515/CCLM.2008.280",
language = "English",
volume = "46",
pages = "1410--1415",
journal = "Clinical Chemistry and Laboratory Medicine",
issn = "1434-6621",
publisher = "Walter de Gruyter GmbH & Co. KG",
number = "10",

}

Association of serum γ-glutamyltransferase with C-reactive protein levels and white blood cell count in Korean adults. / Lee, Yongjae; Kim, Jong Koo; Lee, Jung Hyun; Lee, Hye Ree; Kang, Dae Ryong; Shim, Jae Yong.

In: Clinical Chemistry and Laboratory Medicine, Vol. 46, No. 10, 01.10.2008, p. 1410-1415.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Association of serum γ-glutamyltransferase with C-reactive protein levels and white blood cell count in Korean adults

AU - Lee, Yongjae

AU - Kim, Jong Koo

AU - Lee, Jung Hyun

AU - Lee, Hye Ree

AU - Kang, Dae Ryong

AU - Shim, Jae Yong

PY - 2008/10/1

Y1 - 2008/10/1

N2 - Background: Elevated γ-glutamyltransferase (GGT) has emerged as an independent predictor of cardiovascular disease (CVD) which is increasingly viewed as an inflammatory disease. Thus, the mechanism underlying the link between elevated GGT and CVD may be inflammation. Methods: We examined the relationship between GGT and C-reactive protein (CRP) levels and white blood cell (WBC) count in 4562 Korean adults (2104 men, 2458 women). The odds ratio (OR) and 95% confidence interval (CI) for high CRP and WBC count (≥75th percentile) for both men and women were calculated across each quartile of serum GGT. Results: Results for the OR (95% CI) for high CRP levels by GGT quartiles were 1.00, 1.67 (1.21-2.29), 2.10 (1.51-2.93) and 2.51 (1.81-3.60) in men, and 1.00, 1.05 (0.65-1.68), 1.45 (0.79-2.02) and 2.16 (1.37-3.41) in women after adjustment for age, smoking status, alcohol intake, exercise, body mass index, blood pressure, fasting plasma glucose, triglyceride, high-density lipoprotein-cholesterol, and uric acid. Similarly, positive associations between serum GGT and WBC count were also observed. Conclusions: The present study demonstrates a positive correlation between GGT and two markers of inflammation, serum CRP and WBC count. Our findings suggest that serum GGT may be a surrogate inflammatory marker and a useful additional measure in assessing cardiovascular risk.

AB - Background: Elevated γ-glutamyltransferase (GGT) has emerged as an independent predictor of cardiovascular disease (CVD) which is increasingly viewed as an inflammatory disease. Thus, the mechanism underlying the link between elevated GGT and CVD may be inflammation. Methods: We examined the relationship between GGT and C-reactive protein (CRP) levels and white blood cell (WBC) count in 4562 Korean adults (2104 men, 2458 women). The odds ratio (OR) and 95% confidence interval (CI) for high CRP and WBC count (≥75th percentile) for both men and women were calculated across each quartile of serum GGT. Results: Results for the OR (95% CI) for high CRP levels by GGT quartiles were 1.00, 1.67 (1.21-2.29), 2.10 (1.51-2.93) and 2.51 (1.81-3.60) in men, and 1.00, 1.05 (0.65-1.68), 1.45 (0.79-2.02) and 2.16 (1.37-3.41) in women after adjustment for age, smoking status, alcohol intake, exercise, body mass index, blood pressure, fasting plasma glucose, triglyceride, high-density lipoprotein-cholesterol, and uric acid. Similarly, positive associations between serum GGT and WBC count were also observed. Conclusions: The present study demonstrates a positive correlation between GGT and two markers of inflammation, serum CRP and WBC count. Our findings suggest that serum GGT may be a surrogate inflammatory marker and a useful additional measure in assessing cardiovascular risk.

UR - http://www.scopus.com/inward/record.url?scp=53849123305&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=53849123305&partnerID=8YFLogxK

U2 - 10.1515/CCLM.2008.280

DO - 10.1515/CCLM.2008.280

M3 - Article

VL - 46

SP - 1410

EP - 1415

JO - Clinical Chemistry and Laboratory Medicine

JF - Clinical Chemistry and Laboratory Medicine

SN - 1434-6621

IS - 10

ER -