TY - JOUR
T1 - Association of serum γ-glutamyltransferase with C-reactive protein levels and white blood cell count in Korean adults
AU - Lee, Yong Jae
AU - Kim, Jong Koo
AU - Lee, Jung Hyun
AU - Lee, Hye Ree
AU - Kang, Dae Ryong
AU - Shim, Jae Yong
PY - 2008/10/1
Y1 - 2008/10/1
N2 - Background: Elevated γ-glutamyltransferase (GGT) has emerged as an independent predictor of cardiovascular disease (CVD) which is increasingly viewed as an inflammatory disease. Thus, the mechanism underlying the link between elevated GGT and CVD may be inflammation. Methods: We examined the relationship between GGT and C-reactive protein (CRP) levels and white blood cell (WBC) count in 4562 Korean adults (2104 men, 2458 women). The odds ratio (OR) and 95% confidence interval (CI) for high CRP and WBC count (≥75th percentile) for both men and women were calculated across each quartile of serum GGT. Results: Results for the OR (95% CI) for high CRP levels by GGT quartiles were 1.00, 1.67 (1.21-2.29), 2.10 (1.51-2.93) and 2.51 (1.81-3.60) in men, and 1.00, 1.05 (0.65-1.68), 1.45 (0.79-2.02) and 2.16 (1.37-3.41) in women after adjustment for age, smoking status, alcohol intake, exercise, body mass index, blood pressure, fasting plasma glucose, triglyceride, high-density lipoprotein-cholesterol, and uric acid. Similarly, positive associations between serum GGT and WBC count were also observed. Conclusions: The present study demonstrates a positive correlation between GGT and two markers of inflammation, serum CRP and WBC count. Our findings suggest that serum GGT may be a surrogate inflammatory marker and a useful additional measure in assessing cardiovascular risk.
AB - Background: Elevated γ-glutamyltransferase (GGT) has emerged as an independent predictor of cardiovascular disease (CVD) which is increasingly viewed as an inflammatory disease. Thus, the mechanism underlying the link between elevated GGT and CVD may be inflammation. Methods: We examined the relationship between GGT and C-reactive protein (CRP) levels and white blood cell (WBC) count in 4562 Korean adults (2104 men, 2458 women). The odds ratio (OR) and 95% confidence interval (CI) for high CRP and WBC count (≥75th percentile) for both men and women were calculated across each quartile of serum GGT. Results: Results for the OR (95% CI) for high CRP levels by GGT quartiles were 1.00, 1.67 (1.21-2.29), 2.10 (1.51-2.93) and 2.51 (1.81-3.60) in men, and 1.00, 1.05 (0.65-1.68), 1.45 (0.79-2.02) and 2.16 (1.37-3.41) in women after adjustment for age, smoking status, alcohol intake, exercise, body mass index, blood pressure, fasting plasma glucose, triglyceride, high-density lipoprotein-cholesterol, and uric acid. Similarly, positive associations between serum GGT and WBC count were also observed. Conclusions: The present study demonstrates a positive correlation between GGT and two markers of inflammation, serum CRP and WBC count. Our findings suggest that serum GGT may be a surrogate inflammatory marker and a useful additional measure in assessing cardiovascular risk.
UR - http://www.scopus.com/inward/record.url?scp=53849123305&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=53849123305&partnerID=8YFLogxK
U2 - 10.1515/CCLM.2008.280
DO - 10.1515/CCLM.2008.280
M3 - Article
C2 - 18844495
AN - SCOPUS:53849123305
VL - 46
SP - 1410
EP - 1415
JO - Zeitschrift fur klinische Chemie und klinische Biochemie
JF - Zeitschrift fur klinische Chemie und klinische Biochemie
SN - 1434-6621
IS - 10
ER -