Association of serum adiponectin concentration with aortic arterial stiffness in chronic kidney disease: from the KNOW-CKD study

Representing KNOW-CKD Study Group

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Background: High serum adiponectin levels predict all-cause and cardiovascular mortality in chronic kidney disease (CKD). However, the relationship between serum adiponectin concentration and arterial stiffness in CKD is not well established. The aim of this study was to assess this relationship by measuring pulse wave velocity (PWV) in CKD patients. Methods: Serum adiponectin concentration was measured in 716 CKD patients in the prospective KoreaN cohort study for Outcome in patients With Chronic Kidney Disease. The study group consisted of 415 men and 301 women; mean age was 53.1 years, and baseline estimated glomerular filtration rate (eGFR) was 51 ± 29 ml/min per 1.73 m2. Heart to femoral PWV (hfPWV) and mean brachial to ankle PWV (baPWV) served as indicators of aortic artery stiffness and arterial stiffness, respectively. Results: Increasing quartiles of serum adiponectin levels were associated with women, lower eGFRs and body mass indices, and higher urinary albumin-creatinine ratios. Serum adiponectin concentration also correlated with hfPWV and mean baPWV, even after adjusting for age and sex. It independently associated with hfPWV (B 0.028; 95 % confidence interval, 0.004–0.051; P = 0.020) but not mean baPWV in a multivariable linear regression analysis. In a multivariable logistic regression analysis, it correlated significantly with the highest quartile of hfPWVs but not mean baPWVs. Conclusion: The independent and significant correlation of serum adiponectin concentration with hfPWV in CKD patients implicates adiponectin in CKD-associated aortic stiffness.

Original languageEnglish
Pages (from-to)608-616
Number of pages9
JournalClinical and Experimental Nephrology
Volume21
Issue number4
DOIs
Publication statusPublished - 2017 Aug 1

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Vascular Stiffness
Adiponectin
Chronic Renal Insufficiency
Thigh
Pulse Wave Analysis
Serum
Ankle
Arm
Regression Analysis
Glomerular Filtration Rate
Albumins
Linear Models
Creatinine
Body Mass Index
Cohort Studies
Arteries
Logistic Models
Confidence Intervals
Mortality

All Science Journal Classification (ASJC) codes

  • Physiology
  • Nephrology
  • Physiology (medical)

Cite this

@article{94baa75074f84eb3b767762741536afa,
title = "Association of serum adiponectin concentration with aortic arterial stiffness in chronic kidney disease: from the KNOW-CKD study",
abstract = "Background: High serum adiponectin levels predict all-cause and cardiovascular mortality in chronic kidney disease (CKD). However, the relationship between serum adiponectin concentration and arterial stiffness in CKD is not well established. The aim of this study was to assess this relationship by measuring pulse wave velocity (PWV) in CKD patients. Methods: Serum adiponectin concentration was measured in 716 CKD patients in the prospective KoreaN cohort study for Outcome in patients With Chronic Kidney Disease. The study group consisted of 415 men and 301 women; mean age was 53.1 years, and baseline estimated glomerular filtration rate (eGFR) was 51 ± 29 ml/min per 1.73 m2. Heart to femoral PWV (hfPWV) and mean brachial to ankle PWV (baPWV) served as indicators of aortic artery stiffness and arterial stiffness, respectively. Results: Increasing quartiles of serum adiponectin levels were associated with women, lower eGFRs and body mass indices, and higher urinary albumin-creatinine ratios. Serum adiponectin concentration also correlated with hfPWV and mean baPWV, even after adjusting for age and sex. It independently associated with hfPWV (B 0.028; 95 {\%} confidence interval, 0.004–0.051; P = 0.020) but not mean baPWV in a multivariable linear regression analysis. In a multivariable logistic regression analysis, it correlated significantly with the highest quartile of hfPWVs but not mean baPWVs. Conclusion: The independent and significant correlation of serum adiponectin concentration with hfPWV in CKD patients implicates adiponectin in CKD-associated aortic stiffness.",
author = "{Representing KNOW-CKD Study Group} and Kim, {Chang Seong} and Bae, {Eun Hui} and Ma, {Seong Kwon} and Park, {Sue K.} and Lee, {Ju Yeon} and Wookyung Chung and Kyubeck Lee and Kim, {Yeong Hoon} and Oh, {Kook Hwan} and Curie Ahn and Kim, {Soo Wan} and Curie Ahn and Oh, {Kook Hwan} and Chae, {Dong Wan} and Chin, {Ho Jun} and Park, {Hayne Cho} and Seungmi Lee and Jang, {Hyun Hwa} and Cho, {Hyun Jin} and Choi, {Kyu Hun} and Han, {Seung Hyeok} and Yoo, {Tae Hyun} and Lee, {Mi Hyun Yu Kyubeck} and Hyun, {Young Youl} and Kim, {Yong Soo} and Kim, {Sol Ji} and Wookyung Chung and Youkyoung Jang and Park, {Ji Hye} and Hwang, {Young Hwan} and Sung, {Su Ah} and So, {Jeong Ok} and Kim, {Soo Wan} and Lee, {Ji Seon} and Kim, {Yeong Hoon} and Kang, {Sun Woo} and Kim, {Yun Jin} and Park, {Byung Joo} and Park, {Sue K.} and Lee, {Ju Yeon} and Joongyub Lee and Dayeon Nam and Soohee Kang and Heejung Ahn and Donghee Seo and Cho, {Dae Yeon} and Dukhyoung Lee and Hyekyung Park and Eunkyeong Jung and Suyeon Jeong",
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language = "English",
volume = "21",
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Association of serum adiponectin concentration with aortic arterial stiffness in chronic kidney disease : from the KNOW-CKD study. / Representing KNOW-CKD Study Group.

In: Clinical and Experimental Nephrology, Vol. 21, No. 4, 01.08.2017, p. 608-616.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Association of serum adiponectin concentration with aortic arterial stiffness in chronic kidney disease

T2 - from the KNOW-CKD study

AU - Representing KNOW-CKD Study Group

AU - Kim, Chang Seong

AU - Bae, Eun Hui

AU - Ma, Seong Kwon

AU - Park, Sue K.

AU - Lee, Ju Yeon

AU - Chung, Wookyung

AU - Lee, Kyubeck

AU - Kim, Yeong Hoon

AU - Oh, Kook Hwan

AU - Ahn, Curie

AU - Kim, Soo Wan

AU - Ahn, Curie

AU - Oh, Kook Hwan

AU - Chae, Dong Wan

AU - Chin, Ho Jun

AU - Park, Hayne Cho

AU - Lee, Seungmi

AU - Jang, Hyun Hwa

AU - Cho, Hyun Jin

AU - Choi, Kyu Hun

AU - Han, Seung Hyeok

AU - Yoo, Tae Hyun

AU - Lee, Mi Hyun Yu Kyubeck

AU - Hyun, Young Youl

AU - Kim, Yong Soo

AU - Kim, Sol Ji

AU - Chung, Wookyung

AU - Jang, Youkyoung

AU - Park, Ji Hye

AU - Hwang, Young Hwan

AU - Sung, Su Ah

AU - So, Jeong Ok

AU - Kim, Soo Wan

AU - Lee, Ji Seon

AU - Kim, Yeong Hoon

AU - Kang, Sun Woo

AU - Kim, Yun Jin

AU - Park, Byung Joo

AU - Park, Sue K.

AU - Lee, Ju Yeon

AU - Lee, Joongyub

AU - Nam, Dayeon

AU - Kang, Soohee

AU - Ahn, Heejung

AU - Seo, Donghee

AU - Cho, Dae Yeon

AU - Lee, Dukhyoung

AU - Park, Hyekyung

AU - Jung, Eunkyeong

AU - Jeong, Suyeon

PY - 2017/8/1

Y1 - 2017/8/1

N2 - Background: High serum adiponectin levels predict all-cause and cardiovascular mortality in chronic kidney disease (CKD). However, the relationship between serum adiponectin concentration and arterial stiffness in CKD is not well established. The aim of this study was to assess this relationship by measuring pulse wave velocity (PWV) in CKD patients. Methods: Serum adiponectin concentration was measured in 716 CKD patients in the prospective KoreaN cohort study for Outcome in patients With Chronic Kidney Disease. The study group consisted of 415 men and 301 women; mean age was 53.1 years, and baseline estimated glomerular filtration rate (eGFR) was 51 ± 29 ml/min per 1.73 m2. Heart to femoral PWV (hfPWV) and mean brachial to ankle PWV (baPWV) served as indicators of aortic artery stiffness and arterial stiffness, respectively. Results: Increasing quartiles of serum adiponectin levels were associated with women, lower eGFRs and body mass indices, and higher urinary albumin-creatinine ratios. Serum adiponectin concentration also correlated with hfPWV and mean baPWV, even after adjusting for age and sex. It independently associated with hfPWV (B 0.028; 95 % confidence interval, 0.004–0.051; P = 0.020) but not mean baPWV in a multivariable linear regression analysis. In a multivariable logistic regression analysis, it correlated significantly with the highest quartile of hfPWVs but not mean baPWVs. Conclusion: The independent and significant correlation of serum adiponectin concentration with hfPWV in CKD patients implicates adiponectin in CKD-associated aortic stiffness.

AB - Background: High serum adiponectin levels predict all-cause and cardiovascular mortality in chronic kidney disease (CKD). However, the relationship between serum adiponectin concentration and arterial stiffness in CKD is not well established. The aim of this study was to assess this relationship by measuring pulse wave velocity (PWV) in CKD patients. Methods: Serum adiponectin concentration was measured in 716 CKD patients in the prospective KoreaN cohort study for Outcome in patients With Chronic Kidney Disease. The study group consisted of 415 men and 301 women; mean age was 53.1 years, and baseline estimated glomerular filtration rate (eGFR) was 51 ± 29 ml/min per 1.73 m2. Heart to femoral PWV (hfPWV) and mean brachial to ankle PWV (baPWV) served as indicators of aortic artery stiffness and arterial stiffness, respectively. Results: Increasing quartiles of serum adiponectin levels were associated with women, lower eGFRs and body mass indices, and higher urinary albumin-creatinine ratios. Serum adiponectin concentration also correlated with hfPWV and mean baPWV, even after adjusting for age and sex. It independently associated with hfPWV (B 0.028; 95 % confidence interval, 0.004–0.051; P = 0.020) but not mean baPWV in a multivariable linear regression analysis. In a multivariable logistic regression analysis, it correlated significantly with the highest quartile of hfPWVs but not mean baPWVs. Conclusion: The independent and significant correlation of serum adiponectin concentration with hfPWV in CKD patients implicates adiponectin in CKD-associated aortic stiffness.

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U2 - 10.1007/s10157-016-1322-4

DO - 10.1007/s10157-016-1322-4

M3 - Article

C2 - 27514393

AN - SCOPUS:84981556641

VL - 21

SP - 608

EP - 616

JO - Clinical and Experimental Nephrology

JF - Clinical and Experimental Nephrology

SN - 1342-1751

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