Association of serum ferritin levels with non-alcoholic fatty liver disease in postmenopausal women

H. B. Kim, H. S. Lee, Y. J. Lee

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Objective: This study aimed to investigate the association between serum ferritin levels and the presence of non-alcoholic fatty liver disease (NAFLD) in postmenopausal women. Methods: Two hundred and forty-one postmenopausal women who participated in a heath examination program were enrolled in the present study. Serum ferritin tertiles were categorized as follows: T1, ≤46.4 ng/ml; T2, 46.5–76.1 ng/ml; and T3, ≥76.2 ng/ml. The odds ratios (ORs) and 95% confidence intervals (CIs) for NAFLD were calculated after adjusting for confounding variables across serum ferritin tertiles using multiple logistic regression analysis. Results: The overall prevalence of NAFLD was 41.4% and was significantly increased in accordance with the serum ferritin tertiles as follows: 30.0% for T1, 40.7% for T2, and 54.3% for T3, respectively. As compared with the lowest tertile, the OR (95% CI) for NAFLD in the highest tertile was 2.69 (1.16–5.28) after adjusting for age, body mass index, regular exercise, mean arterial pressure, fasting plasma glucose, triglyceride, high-density lipoprotein cholesterol, alanine aminotransferase, and leukocyte count. Conclusion: The serum ferritin level was positively and independently associated with NAFLD in postmenopausal women and could be a useful additional measure in assessing the risk of NAFLD in postmenopausal women.

Original languageEnglish
Pages (from-to)509-514
Number of pages6
JournalClimacteric
Volume21
Issue number5
DOIs
Publication statusPublished - 2018 Sep 3

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Ferritins
Serum
Odds Ratio
Confidence Intervals
Confounding Factors (Epidemiology)
Alanine Transaminase
Leukocyte Count
HDL Cholesterol
Non-alcoholic Fatty Liver Disease
Fasting
Arterial Pressure
Triglycerides
Body Mass Index
Logistic Models
Regression Analysis
Exercise
Glucose

All Science Journal Classification (ASJC) codes

  • Obstetrics and Gynaecology

Cite this

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title = "Association of serum ferritin levels with non-alcoholic fatty liver disease in postmenopausal women",
abstract = "Objective: This study aimed to investigate the association between serum ferritin levels and the presence of non-alcoholic fatty liver disease (NAFLD) in postmenopausal women. Methods: Two hundred and forty-one postmenopausal women who participated in a heath examination program were enrolled in the present study. Serum ferritin tertiles were categorized as follows: T1, ≤46.4 ng/ml; T2, 46.5–76.1 ng/ml; and T3, ≥76.2 ng/ml. The odds ratios (ORs) and 95{\%} confidence intervals (CIs) for NAFLD were calculated after adjusting for confounding variables across serum ferritin tertiles using multiple logistic regression analysis. Results: The overall prevalence of NAFLD was 41.4{\%} and was significantly increased in accordance with the serum ferritin tertiles as follows: 30.0{\%} for T1, 40.7{\%} for T2, and 54.3{\%} for T3, respectively. As compared with the lowest tertile, the OR (95{\%} CI) for NAFLD in the highest tertile was 2.69 (1.16–5.28) after adjusting for age, body mass index, regular exercise, mean arterial pressure, fasting plasma glucose, triglyceride, high-density lipoprotein cholesterol, alanine aminotransferase, and leukocyte count. Conclusion: The serum ferritin level was positively and independently associated with NAFLD in postmenopausal women and could be a useful additional measure in assessing the risk of NAFLD in postmenopausal women.",
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Association of serum ferritin levels with non-alcoholic fatty liver disease in postmenopausal women. / Kim, H. B.; Lee, H. S.; Lee, Y. J.

In: Climacteric, Vol. 21, No. 5, 03.09.2018, p. 509-514.

Research output: Contribution to journalArticle

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AB - Objective: This study aimed to investigate the association between serum ferritin levels and the presence of non-alcoholic fatty liver disease (NAFLD) in postmenopausal women. Methods: Two hundred and forty-one postmenopausal women who participated in a heath examination program were enrolled in the present study. Serum ferritin tertiles were categorized as follows: T1, ≤46.4 ng/ml; T2, 46.5–76.1 ng/ml; and T3, ≥76.2 ng/ml. The odds ratios (ORs) and 95% confidence intervals (CIs) for NAFLD were calculated after adjusting for confounding variables across serum ferritin tertiles using multiple logistic regression analysis. Results: The overall prevalence of NAFLD was 41.4% and was significantly increased in accordance with the serum ferritin tertiles as follows: 30.0% for T1, 40.7% for T2, and 54.3% for T3, respectively. As compared with the lowest tertile, the OR (95% CI) for NAFLD in the highest tertile was 2.69 (1.16–5.28) after adjusting for age, body mass index, regular exercise, mean arterial pressure, fasting plasma glucose, triglyceride, high-density lipoprotein cholesterol, alanine aminotransferase, and leukocyte count. Conclusion: The serum ferritin level was positively and independently associated with NAFLD in postmenopausal women and could be a useful additional measure in assessing the risk of NAFLD in postmenopausal women.

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