Association of serum proprotein convertase subtilisin/kexin type 9 with carotid intima media thickness in hypertensive subjects

Chan Joo Lee, Yong Ho Lee, Sahng Wook Park, Kwang Joon Kim, Sungha Park, Jong Chan Youn, Sang Hak Lee, seokmin kang, Yangsoo Jang

Research output: Contribution to journalArticle

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Abstract

Objective The clinical significance of the measurement of serum PCSK9 (proprotein subtilisin kexin type 9) is not well defined. This study investigated the association between serum PCSK9 levels and atherosclerosis assessed by carotid intima media thickness (IMT) in hypertensive patients. Methods A total of 126 hypertensive patients over the age of 45 were enrolled. The maximum carotid IMT (max-IMT) and the mean carotid IMT (mean-IMT) were measured at the time of enrollment. Clinical and laboratory parameters including serum PCSK9 were analyzed. Results Patients were divided into tertiles based on serum PCSK9 levels. After adjusting for age, sex, total cholesterol, HDL-cholesterol and triglyceride, max-IMT was significantly increased in the highest tertile of serum PCSK9 (0.969 ± 0.033 vs 0.959 ± 0.033 vs 1.077 ± 0.033 mm, respectively; P = 0.026). Mean-IMT showed a tendency to increase across the tertile groups (0.773 ± 0.025 vs 0.790 ± 0.026 vs 0.856 ± 0.025 mm, respectively; P = 0.059). Multivariate regression analysis revealed that serum PCSK9 was independently associated with carotid IMT (max-IMT: β = 0.212, P = 0.016; mean-IMT: β = 0.184, P = 0.04). Conclusion The present study is the first to report the association between serum PCSK9 levels and carotid IMT in hypertensive patients. These results suggest that serum PCSK9 may have a certain role in early pathogenesis of atherosclerosis.

Original languageEnglish
Pages (from-to)845-850
Number of pages6
JournalMetabolism: Clinical and Experimental
Volume62
Issue number6
DOIs
Publication statusPublished - 2013 Jun 1

Fingerprint

Carotid Intima-Media Thickness
Serum
Atherosclerosis
Subtilisin
Proprotein Convertase 9
HDL Cholesterol
Triglycerides
Multivariate Analysis
Cholesterol
Regression Analysis

All Science Journal Classification (ASJC) codes

  • Endocrinology, Diabetes and Metabolism
  • Endocrinology

Cite this

Lee, Chan Joo ; Lee, Yong Ho ; Park, Sahng Wook ; Kim, Kwang Joon ; Park, Sungha ; Youn, Jong Chan ; Lee, Sang Hak ; kang, seokmin ; Jang, Yangsoo. / Association of serum proprotein convertase subtilisin/kexin type 9 with carotid intima media thickness in hypertensive subjects. In: Metabolism: Clinical and Experimental. 2013 ; Vol. 62, No. 6. pp. 845-850.
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Association of serum proprotein convertase subtilisin/kexin type 9 with carotid intima media thickness in hypertensive subjects. / Lee, Chan Joo; Lee, Yong Ho; Park, Sahng Wook; Kim, Kwang Joon; Park, Sungha; Youn, Jong Chan; Lee, Sang Hak; kang, seokmin; Jang, Yangsoo.

In: Metabolism: Clinical and Experimental, Vol. 62, No. 6, 01.06.2013, p. 845-850.

Research output: Contribution to journalArticle

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AU - Lee, Chan Joo

AU - Lee, Yong Ho

AU - Park, Sahng Wook

AU - Kim, Kwang Joon

AU - Park, Sungha

AU - Youn, Jong Chan

AU - Lee, Sang Hak

AU - kang, seokmin

AU - Jang, Yangsoo

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N2 - Objective The clinical significance of the measurement of serum PCSK9 (proprotein subtilisin kexin type 9) is not well defined. This study investigated the association between serum PCSK9 levels and atherosclerosis assessed by carotid intima media thickness (IMT) in hypertensive patients. Methods A total of 126 hypertensive patients over the age of 45 were enrolled. The maximum carotid IMT (max-IMT) and the mean carotid IMT (mean-IMT) were measured at the time of enrollment. Clinical and laboratory parameters including serum PCSK9 were analyzed. Results Patients were divided into tertiles based on serum PCSK9 levels. After adjusting for age, sex, total cholesterol, HDL-cholesterol and triglyceride, max-IMT was significantly increased in the highest tertile of serum PCSK9 (0.969 ± 0.033 vs 0.959 ± 0.033 vs 1.077 ± 0.033 mm, respectively; P = 0.026). Mean-IMT showed a tendency to increase across the tertile groups (0.773 ± 0.025 vs 0.790 ± 0.026 vs 0.856 ± 0.025 mm, respectively; P = 0.059). Multivariate regression analysis revealed that serum PCSK9 was independently associated with carotid IMT (max-IMT: β = 0.212, P = 0.016; mean-IMT: β = 0.184, P = 0.04). Conclusion The present study is the first to report the association between serum PCSK9 levels and carotid IMT in hypertensive patients. These results suggest that serum PCSK9 may have a certain role in early pathogenesis of atherosclerosis.

AB - Objective The clinical significance of the measurement of serum PCSK9 (proprotein subtilisin kexin type 9) is not well defined. This study investigated the association between serum PCSK9 levels and atherosclerosis assessed by carotid intima media thickness (IMT) in hypertensive patients. Methods A total of 126 hypertensive patients over the age of 45 were enrolled. The maximum carotid IMT (max-IMT) and the mean carotid IMT (mean-IMT) were measured at the time of enrollment. Clinical and laboratory parameters including serum PCSK9 were analyzed. Results Patients were divided into tertiles based on serum PCSK9 levels. After adjusting for age, sex, total cholesterol, HDL-cholesterol and triglyceride, max-IMT was significantly increased in the highest tertile of serum PCSK9 (0.969 ± 0.033 vs 0.959 ± 0.033 vs 1.077 ± 0.033 mm, respectively; P = 0.026). Mean-IMT showed a tendency to increase across the tertile groups (0.773 ± 0.025 vs 0.790 ± 0.026 vs 0.856 ± 0.025 mm, respectively; P = 0.059). Multivariate regression analysis revealed that serum PCSK9 was independently associated with carotid IMT (max-IMT: β = 0.212, P = 0.016; mean-IMT: β = 0.184, P = 0.04). Conclusion The present study is the first to report the association between serum PCSK9 levels and carotid IMT in hypertensive patients. These results suggest that serum PCSK9 may have a certain role in early pathogenesis of atherosclerosis.

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