Association of Shh and Ptc with keratin localization in the initiation of the formation of circumvallate papilla and von Ebner's gland

Min Jung Lee, Jae Young Kim, Syng Ill Lee, Hodaka Sasaki, Declan P. Lunny, E. Birgitte Lane, Hansung Jung

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

The development of gustatory papillae in mammalian embryos requires the coordination of a series of morphological events, such as proliferation, differentiation and innervation. In mice, the circumvallate papilla (CVP) is a specialized structure that develops in a characteristic spatial and temporal pattern in the posterior region of the tongue dorsal surface. The distinct expression patterns of Shh and Ptc, which play important roles in the development of other epithelial appendages, have been localized in the trench wall that gives rise to von Ebner's gland (VEG). To define the cellular mechanisms responsible for morphogenesis and differentiation during early development of CVP and VEG, the localization patterns of keratins (cytokeratins) K7, K8, K18, K19, K14 and connexin-43, which are dependent on Shh expression in other developmental systems, have been examined in detail. The distinct localization of keratins K7, K8, K18, K19, K14 and connexin-43 in the epithelium giving rise to the CVP and VEG suggests that cytodifferentiation is established prior to morphological changes. Interestingly, the localization of proliferating cell nuclear antigen, a marker for cell proliferation, is similar to that of Shh. An understanding of the regulatory roles of cell-cell interactions and signalling molecules in orchestrating a mutual network will bring us nearer to defining the molecular and cellular mechanisms underlying morphogenesis in mammalian taste bud development.

Original languageEnglish
Pages (from-to)253-261
Number of pages9
JournalCell and Tissue Research
Volume325
Issue number2
DOIs
Publication statusPublished - 2006 Aug 1

Fingerprint

von Ebner Glands
Keratins
Connexin 43
Morphogenesis
Mammalian Embryo
Taste Buds
Proliferating Cell Nuclear Antigen
Tongue
Cell Communication
Epithelium
Cell Proliferation
K-18 conjugate

All Science Journal Classification (ASJC) codes

  • Pathology and Forensic Medicine
  • Histology
  • Cell Biology

Cite this

Lee, Min Jung ; Kim, Jae Young ; Lee, Syng Ill ; Sasaki, Hodaka ; Lunny, Declan P. ; Lane, E. Birgitte ; Jung, Hansung. / Association of Shh and Ptc with keratin localization in the initiation of the formation of circumvallate papilla and von Ebner's gland. In: Cell and Tissue Research. 2006 ; Vol. 325, No. 2. pp. 253-261.
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Association of Shh and Ptc with keratin localization in the initiation of the formation of circumvallate papilla and von Ebner's gland. / Lee, Min Jung; Kim, Jae Young; Lee, Syng Ill; Sasaki, Hodaka; Lunny, Declan P.; Lane, E. Birgitte; Jung, Hansung.

In: Cell and Tissue Research, Vol. 325, No. 2, 01.08.2006, p. 253-261.

Research output: Contribution to journalArticle

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