Association of signal transducer and activator of transcription 4 genetic variants with extra-intestinal manifestations in inflammatory bowel disease

Chang Mo Moon, JaeHee Cheon, Seung Won Kim, Dong Jik Shin, Eun Soo Kim, Eun Soon Shin, Yoon Kang, Jae Jun Park, Sung Pil Hong, Su Youn Nam, Tae Il Kim, Won Ho Kim

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

Aims: The STAT4 gene encodes a transcription factor which plays an important role in the development of inflammation of many immune-mediated diseases. We investigated the relationship between STAT4 single nucleotide polymorphisms (SNPs) and susceptibility to ulcerative colitis (UC) and Crohn's disease (CD) and disease phenotypes in the Korean population. Main methods: We performed a case-control association study in individuals with UC (N=246), CD (N=182), and healthy controls (N=229). Key findings: We genotyped 8 STAT4 SNPs (rs11889341, rs7574865, rs8179673, rs6752770, rs925847, rs10168266, rs10181656, and rs11685878) in the STAT4 gene in patients and controls. SNP rs925847 in the STAT4 gene was significantly associated with susceptibility to UC (P=0.025; OR. =0.63) in dominant genotype analysis, though none of these SNPs were associated with CD susceptibility. Moreover, a significant association was identified between SNP rs11889341 and joint involvement (P=0.040; OR. =3.79), and between SNP rs925847 and eye involvement (P=0.030; OR. =2.42) in UC patients. For CD, rs925847 genetic variant was associated with joint (P=0.029; OR. =3.93) and perianal lesions (P=0.033; OR. =2.27). Significance: Our data demonstrated that the STAT4 genetic variants could predispose an individual to IBD and its extra-intestinal ailments in Koreans, suggesting the common pathogenesis of IBD (especially, extra-intestinal manifestations) and other autoimmune diseases.

Original languageEnglish
Pages (from-to)661-667
Number of pages7
JournalLife Sciences
Volume86
Issue number17-18
DOIs
Publication statusPublished - 2010 Apr 1

Fingerprint

STAT4 Transcription Factor
Inflammatory Bowel Diseases
Single Nucleotide Polymorphism
Polymorphism
Nucleotides
Ulcerative Colitis
Crohn Disease
Genes
Joints
Disease Susceptibility
Immune System Diseases
Autoimmune Diseases
Case-Control Studies
Transcription Factors
Genotype
Inflammation
Phenotype

All Science Journal Classification (ASJC) codes

  • Biochemistry, Genetics and Molecular Biology(all)
  • Pharmacology, Toxicology and Pharmaceutics(all)

Cite this

Moon, Chang Mo ; Cheon, JaeHee ; Kim, Seung Won ; Shin, Dong Jik ; Kim, Eun Soo ; Shin, Eun Soon ; Kang, Yoon ; Park, Jae Jun ; Hong, Sung Pil ; Nam, Su Youn ; Kim, Tae Il ; Kim, Won Ho. / Association of signal transducer and activator of transcription 4 genetic variants with extra-intestinal manifestations in inflammatory bowel disease. In: Life Sciences. 2010 ; Vol. 86, No. 17-18. pp. 661-667.
@article{387bdfaa4eb74133a003acd8edd19ded,
title = "Association of signal transducer and activator of transcription 4 genetic variants with extra-intestinal manifestations in inflammatory bowel disease",
abstract = "Aims: The STAT4 gene encodes a transcription factor which plays an important role in the development of inflammation of many immune-mediated diseases. We investigated the relationship between STAT4 single nucleotide polymorphisms (SNPs) and susceptibility to ulcerative colitis (UC) and Crohn's disease (CD) and disease phenotypes in the Korean population. Main methods: We performed a case-control association study in individuals with UC (N=246), CD (N=182), and healthy controls (N=229). Key findings: We genotyped 8 STAT4 SNPs (rs11889341, rs7574865, rs8179673, rs6752770, rs925847, rs10168266, rs10181656, and rs11685878) in the STAT4 gene in patients and controls. SNP rs925847 in the STAT4 gene was significantly associated with susceptibility to UC (P=0.025; OR. =0.63) in dominant genotype analysis, though none of these SNPs were associated with CD susceptibility. Moreover, a significant association was identified between SNP rs11889341 and joint involvement (P=0.040; OR. =3.79), and between SNP rs925847 and eye involvement (P=0.030; OR. =2.42) in UC patients. For CD, rs925847 genetic variant was associated with joint (P=0.029; OR. =3.93) and perianal lesions (P=0.033; OR. =2.27). Significance: Our data demonstrated that the STAT4 genetic variants could predispose an individual to IBD and its extra-intestinal ailments in Koreans, suggesting the common pathogenesis of IBD (especially, extra-intestinal manifestations) and other autoimmune diseases.",
author = "Moon, {Chang Mo} and JaeHee Cheon and Kim, {Seung Won} and Shin, {Dong Jik} and Kim, {Eun Soo} and Shin, {Eun Soon} and Yoon Kang and Park, {Jae Jun} and Hong, {Sung Pil} and Nam, {Su Youn} and Kim, {Tae Il} and Kim, {Won Ho}",
year = "2010",
month = "4",
day = "1",
doi = "10.1016/j.lfs.2010.02.016",
language = "English",
volume = "86",
pages = "661--667",
journal = "Life Sciences",
issn = "0024-3205",
publisher = "Elsevier Inc.",
number = "17-18",

}

Moon, CM, Cheon, J, Kim, SW, Shin, DJ, Kim, ES, Shin, ES, Kang, Y, Park, JJ, Hong, SP, Nam, SY, Kim, TI & Kim, WH 2010, 'Association of signal transducer and activator of transcription 4 genetic variants with extra-intestinal manifestations in inflammatory bowel disease', Life Sciences, vol. 86, no. 17-18, pp. 661-667. https://doi.org/10.1016/j.lfs.2010.02.016

Association of signal transducer and activator of transcription 4 genetic variants with extra-intestinal manifestations in inflammatory bowel disease. / Moon, Chang Mo; Cheon, JaeHee; Kim, Seung Won; Shin, Dong Jik; Kim, Eun Soo; Shin, Eun Soon; Kang, Yoon; Park, Jae Jun; Hong, Sung Pil; Nam, Su Youn; Kim, Tae Il; Kim, Won Ho.

In: Life Sciences, Vol. 86, No. 17-18, 01.04.2010, p. 661-667.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Association of signal transducer and activator of transcription 4 genetic variants with extra-intestinal manifestations in inflammatory bowel disease

AU - Moon, Chang Mo

AU - Cheon, JaeHee

AU - Kim, Seung Won

AU - Shin, Dong Jik

AU - Kim, Eun Soo

AU - Shin, Eun Soon

AU - Kang, Yoon

AU - Park, Jae Jun

AU - Hong, Sung Pil

AU - Nam, Su Youn

AU - Kim, Tae Il

AU - Kim, Won Ho

PY - 2010/4/1

Y1 - 2010/4/1

N2 - Aims: The STAT4 gene encodes a transcription factor which plays an important role in the development of inflammation of many immune-mediated diseases. We investigated the relationship between STAT4 single nucleotide polymorphisms (SNPs) and susceptibility to ulcerative colitis (UC) and Crohn's disease (CD) and disease phenotypes in the Korean population. Main methods: We performed a case-control association study in individuals with UC (N=246), CD (N=182), and healthy controls (N=229). Key findings: We genotyped 8 STAT4 SNPs (rs11889341, rs7574865, rs8179673, rs6752770, rs925847, rs10168266, rs10181656, and rs11685878) in the STAT4 gene in patients and controls. SNP rs925847 in the STAT4 gene was significantly associated with susceptibility to UC (P=0.025; OR. =0.63) in dominant genotype analysis, though none of these SNPs were associated with CD susceptibility. Moreover, a significant association was identified between SNP rs11889341 and joint involvement (P=0.040; OR. =3.79), and between SNP rs925847 and eye involvement (P=0.030; OR. =2.42) in UC patients. For CD, rs925847 genetic variant was associated with joint (P=0.029; OR. =3.93) and perianal lesions (P=0.033; OR. =2.27). Significance: Our data demonstrated that the STAT4 genetic variants could predispose an individual to IBD and its extra-intestinal ailments in Koreans, suggesting the common pathogenesis of IBD (especially, extra-intestinal manifestations) and other autoimmune diseases.

AB - Aims: The STAT4 gene encodes a transcription factor which plays an important role in the development of inflammation of many immune-mediated diseases. We investigated the relationship between STAT4 single nucleotide polymorphisms (SNPs) and susceptibility to ulcerative colitis (UC) and Crohn's disease (CD) and disease phenotypes in the Korean population. Main methods: We performed a case-control association study in individuals with UC (N=246), CD (N=182), and healthy controls (N=229). Key findings: We genotyped 8 STAT4 SNPs (rs11889341, rs7574865, rs8179673, rs6752770, rs925847, rs10168266, rs10181656, and rs11685878) in the STAT4 gene in patients and controls. SNP rs925847 in the STAT4 gene was significantly associated with susceptibility to UC (P=0.025; OR. =0.63) in dominant genotype analysis, though none of these SNPs were associated with CD susceptibility. Moreover, a significant association was identified between SNP rs11889341 and joint involvement (P=0.040; OR. =3.79), and between SNP rs925847 and eye involvement (P=0.030; OR. =2.42) in UC patients. For CD, rs925847 genetic variant was associated with joint (P=0.029; OR. =3.93) and perianal lesions (P=0.033; OR. =2.27). Significance: Our data demonstrated that the STAT4 genetic variants could predispose an individual to IBD and its extra-intestinal ailments in Koreans, suggesting the common pathogenesis of IBD (especially, extra-intestinal manifestations) and other autoimmune diseases.

UR - http://www.scopus.com/inward/record.url?scp=77951224334&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=77951224334&partnerID=8YFLogxK

U2 - 10.1016/j.lfs.2010.02.016

DO - 10.1016/j.lfs.2010.02.016

M3 - Article

VL - 86

SP - 661

EP - 667

JO - Life Sciences

JF - Life Sciences

SN - 0024-3205

IS - 17-18

ER -