Association of specific immunoglobulin e to staphylococcal enterotoxin with airway hyperresponsiveness in asthma patients

Seong Han Kim, Seo Yeon Yang, Jihong You, Sang Bae Lee, Jin You, Yoon Soo Chang, Hyung Jung Kim, Chul Min Ahn, Min Kwang Byun, Hye Jung Park, Jung Won Park

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Abstract

Background: Specific immunoglobulin E (IgE) sensitization to staphylococcal enterotoxin (SE) has been recently considered to be related to allergic disease, including asthma. Despite studies on specific IgE (sIgE) to SE and its relationship to asthma diagnosis and severity, the association of sIgE to SE with airway hyperresponsiveness (AHR) remains unclear. Methods: We enrolled 81 asthma patients admitted to the Severance Hospital in Korea from March 1, 2013, to February 28, 2015 and retrospectively reviewed the electronic medical records of the enrolled subjects. The serum levels of sIgE to SE (A/ B) of all subjects was measured using the ImmunoCAP 250 (Phadia) system with SE-sIgE positive defined as >0.10 kU/mL. Results: The SE-sIgE level was not significantly correlated with asthma severity (forced expiratory volume in 1 second [FEV1], FEV1/forced vital capacity, sputum eosinophils, and serum eosinophils), whereas the SE-sIgE level in patients with positive AHR (mean±standard error of the mean, 0.606±0.273 kU/mL) was significantly higher than that in patients with negative AHR (0.062±0.015 kU/mL, p=0.034). In regression analysis, SE sensitization (sIgE to SE ≥0.010 kU/mL) was a significant risk factor for AHR, after adjustment for age, sex, FEV1, and sputum eosinophils (odds ratio, 7.090; 95% confidence interval, 1.180-42.600; p=0.032). Prevalence of SE sensitization was higher in patients with allergic rhinitis and non-atopic asthma patients, as compared to patients without allergic rhinitis and atopic asthma patients, respectively, but without statistical significance. Conclusion: SE sensitization is significantly associated with AHR.

Original languageEnglish
Pages (from-to)295-301
Number of pages7
JournalTuberculosis and Respiratory Diseases
Volume79
Issue number4
DOIs
Publication statusPublished - 2016 Oct

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All Science Journal Classification (ASJC) codes

  • Pulmonary and Respiratory Medicine
  • Infectious Diseases

Cite this

Kim, S. H., Yang, S. Y., You, J., Lee, S. B., You, J., Chang, Y. S., Kim, H. J., Ahn, C. M., Byun, M. K., Park, H. J., & Park, J. W. (2016). Association of specific immunoglobulin e to staphylococcal enterotoxin with airway hyperresponsiveness in asthma patients. Tuberculosis and Respiratory Diseases, 79(4), 295-301. https://doi.org/10.4046/trd.2016.79.4.295