Association of the human papillomavirus infection with the recurrence of sinonasal inverted papilloma: a systematic review and meta-analysis

Min Seok Rha, Chang Hoon Kim, Joo Heon Yoon, Hyung Ju Cho

Research output: Contribution to journalReview articlepeer-review

2 Citations (Scopus)


Background: Although the role of human papillomavirus (HPV) in sinonasal inverted papilloma (SNIP) has been investigated, the link between HPV infection and SNIP recurrence remains controversial. This meta-analysis aimed to investigate the association between HPV infection and recurrence of SNIP. Methods: The PubMed, Web of Science, Google Scholar, and Cochrane Library databases were searched (until 16 June 2021) to collect all relevant articles. The pooled odds ratio (OR) with 95% confidence interval (CI) was calculated using the fixed effects model. In addition, subgroup analysis, assessment of publication bias, and sensitivity analyses were performed. Results: Fourteen eligible articles, including 592 patients with SNIP, were included in this study. Pooled analysis revealed that HPV-positive cases exhibited a significantly higher OR of tumour recurrence than HPV-negative counterparts. A significant association between HPV infection and tumour recurrence remained stable in subgroup analyses according to publication year of studies. Conclusions: Our meta-analysis demonstrates that HPV infection is significantly associated with the recurrence of SNIP, sugges-ting the pathological role of HPV in SNIP. These results suggest that HPV infection should be considered in the management of SNIP.

Original languageEnglish
Pages (from-to)2-10
Number of pages9
Issue number1
Publication statusPublished - 2022

Bibliographical note

Funding Information:
This research was supported by a grant of the Korea Health Technology R&D Project through the Korea Health Industry Development Institute (KHIDI), funded by the Ministry of Health & Welfare, Republic of Korea (grant number: HV20C0205), and Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Education (2021R1I1A1A01047571).

Publisher Copyright:
© 2022, International Rhinologic Society. All rights reserved.

All Science Journal Classification (ASJC) codes

  • Otorhinolaryngology


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