Association of white blood cell count with metabolic syndrome in patients undergoing peritoneal dialysis

Jung Tak Park, Tae Ik Chang, Dong Ki Kim, Hoon Young Choi, Jung Eun Lee, Hyun Wook Kim, Jae Hyun Chang, Sun Young Park, Eunyoung Kim, Tae Hyun Yoo, Dae Suk Han, Shin Wook Kang

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Metabolic syndrome is associated with an increased risk of diabetes and cardiovascular disease. Although some data suggest that the prevalence of metabolic syndrome is higher in patients undergoing peritoneal dialysis (PD), the factors related to this increased risk are not well elucidated. We therefore examined whether peripheral white blood cell (WBC) count is correlated with the risk of metabolic syndrome in nondiabetic PD patients. We enrolled 104 nondiabetic PD patients without current infections or chronic inflammatory diseases. Complete blood cell count, anthropometry, blood pressure, fasting glucose, insulin, and lipid profiles were measured. Metabolic syndrome was defined in accordance with the National Cholesterol Education Program (Adult Treatment Panel III) criteria. Metabolic syndrome was present in 49 patients (47.1%). Patients with metabolic syndrome had a higher WBC count and high-sensitivity C-reactive protein level. As the number of metabolic syndrome components increased, WBC count increased significantly. White blood cell count was significantly positively correlated with body mass index, insulin, homeostasis model assessment of insulin resistance, and triglyceride and negatively correlated with high-density lipoprotein cholesterol. The risk of metabolic syndrome increased significantly with a higher WBC count, resulting in an adjusted odds ratio of 1.65 (per 103/μL increase, P = .002). These findings demonstrate that metabolic syndrome is prevalent among nondiabetic PD patients and that WBC count is strongly associated with metabolic syndrome and its components.

Original languageEnglish
Pages (from-to)1379-1385
Number of pages7
JournalMetabolism: Clinical and Experimental
Volume58
Issue number10
DOIs
Publication statusPublished - 2009 Oct 1

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Peritoneal Dialysis
Leukocyte Count
Blood Cell Count
Insulin
Anthropometry
C-Reactive Protein
HDL Cholesterol
Insulin Resistance
Fasting
Triglycerides
Body Mass Index
Homeostasis
Chronic Disease
Cardiovascular Diseases
Odds Ratio
Cholesterol
Blood Pressure
Lipids
Education
Glucose

All Science Journal Classification (ASJC) codes

  • Endocrinology, Diabetes and Metabolism
  • Endocrinology

Cite this

Park, Jung Tak ; Chang, Tae Ik ; Kim, Dong Ki ; Choi, Hoon Young ; Lee, Jung Eun ; Kim, Hyun Wook ; Chang, Jae Hyun ; Park, Sun Young ; Kim, Eunyoung ; Yoo, Tae Hyun ; Han, Dae Suk ; Kang, Shin Wook. / Association of white blood cell count with metabolic syndrome in patients undergoing peritoneal dialysis. In: Metabolism: Clinical and Experimental. 2009 ; Vol. 58, No. 10. pp. 1379-1385.
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Park, JT, Chang, TI, Kim, DK, Choi, HY, Lee, JE, Kim, HW, Chang, JH, Park, SY, Kim, E, Yoo, TH, Han, DS & Kang, SW 2009, 'Association of white blood cell count with metabolic syndrome in patients undergoing peritoneal dialysis', Metabolism: Clinical and Experimental, vol. 58, no. 10, pp. 1379-1385. https://doi.org/10.1016/j.metabol.2009.05.002

Association of white blood cell count with metabolic syndrome in patients undergoing peritoneal dialysis. / Park, Jung Tak; Chang, Tae Ik; Kim, Dong Ki; Choi, Hoon Young; Lee, Jung Eun; Kim, Hyun Wook; Chang, Jae Hyun; Park, Sun Young; Kim, Eunyoung; Yoo, Tae Hyun; Han, Dae Suk; Kang, Shin Wook.

In: Metabolism: Clinical and Experimental, Vol. 58, No. 10, 01.10.2009, p. 1379-1385.

Research output: Contribution to journalArticle

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AU - Lee, Jung Eun

AU - Kim, Hyun Wook

AU - Chang, Jae Hyun

AU - Park, Sun Young

AU - Kim, Eunyoung

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AU - Han, Dae Suk

AU - Kang, Shin Wook

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