Associations among FADS1 rs174547, eicosapentaenoic acid/arachidonic acid ratio, and arterial stiffness in overweight subjects

M. Kim, H. J. Yoo, A. Lee, S. Jeong, J. H. Lee

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7 Citations (Scopus)


We aimed to evaluate the longitudinal interaction effects between the minor allele of FADS1 rs174547 and overweight on n-3 and n-6 long-chain polyunsaturated fatty acid (PUFA) levels and pulse wave velocity (PWV). Plasma PUFA levels were measured via GC-MS, and arterial stiffness was determined as brachial-ankle PWV (ba-PWV) at baseline and after a mean follow-up of 3 years. The FADS1 rs174547 T > C genotype was analyzed. At 3-years of follow-up, after adjustment for age, sex, smoking and drinking, there were interaction effects between the FADS1 rs174547 T > C genotype and baseline BMI on the changes (from baseline) in plasma arachidonic acid (AA) levels, in the eicosapentaenoic acid (EPA)/AA ratio, and in ba-PWV (p for interaction = 0.036, 0.022, and 0.001, respectively). There were smaller increases in AA levels from baseline among normal-weight C allele carriers (n = 112) and overweight TT subjects (n = 47) than among normal-weight TT subjects (n = 91). Overweight C allele carriers (n = 37) showed greater reductions in the plasma EPA/AA ratio and greater increases in ba-PWV than the 3 other populations studied. The minor allele of the FADS1 rs174547 polymorphism is associated with age-related decreases in the EPA/AA ratio and increases in ba-PWV among overweight subjects.

Original languageEnglish
Pages (from-to)11-18
Number of pages8
JournalProstaglandins Leukotrienes and Essential Fatty Acids
Publication statusPublished - 2018 Mar

Bibliographical note

Funding Information:
This study was funded by the Bio-Synergy Research Project ( NRF-2012M3A9C4048762 ) and the Mid-career Researcher Program ( NRF-2016R1A2B4011662 ) of the Ministry of Science, ICT and Future Planning through the National Research Foundation, Republic of Korea.

Publisher Copyright:
© 2018

All Science Journal Classification (ASJC) codes

  • Clinical Biochemistry
  • Cell Biology


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