Associations between absolute neutrophil count and lymphocyte-predominant breast cancer

Chang Ik Yoon, Soeun Park, Yoon Jin Cha, Hye Sun Lee, Soong June Bae, Chihwan Cha, Da Young Lee, Sung Gwe Ahn, Joon Jeong

Research output: Contribution to journalArticle

Abstract

Introduction: Tumor-infiltrating lymphocytes (TILs) might be associated with host-cell mediated immunity, which could be partly reflected by peripheral blood cell counts. In addition, lymphocyte-predominant breast cancer (LPBC), which was defined as tumors having high TIL levels, showed a favorable prognosis among triple-negative breast cancer or HER2-positive breast cancer. We aimed to investigate whether peripheral blood cell counts are associated with LPBC. Methods: We evaluated the percentage of stromal TILs in breast cancer patients who underwent primary surgery, using the standardized methodology proposed by the international TIL Working Group. Lymphocyte-predominant breast cancer (LPBC) was defined as tumors having high TIL levels (≥50%). Peripheral blood cell counts including absolute neutrophil counts (ANC), absolute lymphocyte counts (ALC) and neutrophil-to-lymphocyte ratio (NLR) was obtained from pretreatment laboratory data. Result: Of the 810 patients, 132 (16.3%) had LPBC, and 678 (83.7%) had non-LBPC. In a comparison of 3 markers of peripheral blood counts, LPBC had a significantly lower mean ANC than non-LPBC (3,304 vs. 3,564; P = 0.023), but the other means were not different. In multivariable analysis, each 1K increment in ANC corresponded to an odds ratio of 0.790 (95% CI, 0.642 to 0.971) for LPBC. In the ER-negative and high-Ki67 subgroups identified by interaction tests, significant inverse correlations between continuous ANC and TILs were noted. Conclusion: Low peripheral ANC could be linked with LPBC, supporting the hypothesis that systemic immune cell counts might be associated with the tumor-immune microenvironment.

Original languageEnglish
JournalBreast
DOIs
Publication statusAccepted/In press - 2019 Jan 1

Fingerprint

Lymphocyte Count
Tumor-Infiltrating Lymphocytes
Neutrophils
Breast Neoplasms
Lymphocytes
Blood Cell Count
Triple Negative Breast Neoplasms
Tumor Microenvironment
Cellular Immunity
Neoplasms
Cell Count
Odds Ratio

All Science Journal Classification (ASJC) codes

  • Surgery

Cite this

Yoon, Chang Ik ; Park, Soeun ; Cha, Yoon Jin ; Lee, Hye Sun ; Bae, Soong June ; Cha, Chihwan ; Lee, Da Young ; Ahn, Sung Gwe ; Jeong, Joon. / Associations between absolute neutrophil count and lymphocyte-predominant breast cancer. In: Breast. 2019.
@article{235d04232ff74267ac47b0c4a94f7926,
title = "Associations between absolute neutrophil count and lymphocyte-predominant breast cancer",
abstract = "Introduction: Tumor-infiltrating lymphocytes (TILs) might be associated with host-cell mediated immunity, which could be partly reflected by peripheral blood cell counts. In addition, lymphocyte-predominant breast cancer (LPBC), which was defined as tumors having high TIL levels, showed a favorable prognosis among triple-negative breast cancer or HER2-positive breast cancer. We aimed to investigate whether peripheral blood cell counts are associated with LPBC. Methods: We evaluated the percentage of stromal TILs in breast cancer patients who underwent primary surgery, using the standardized methodology proposed by the international TIL Working Group. Lymphocyte-predominant breast cancer (LPBC) was defined as tumors having high TIL levels (≥50{\%}). Peripheral blood cell counts including absolute neutrophil counts (ANC), absolute lymphocyte counts (ALC) and neutrophil-to-lymphocyte ratio (NLR) was obtained from pretreatment laboratory data. Result: Of the 810 patients, 132 (16.3{\%}) had LPBC, and 678 (83.7{\%}) had non-LBPC. In a comparison of 3 markers of peripheral blood counts, LPBC had a significantly lower mean ANC than non-LPBC (3,304 vs. 3,564; P = 0.023), but the other means were not different. In multivariable analysis, each 1K increment in ANC corresponded to an odds ratio of 0.790 (95{\%} CI, 0.642 to 0.971) for LPBC. In the ER-negative and high-Ki67 subgroups identified by interaction tests, significant inverse correlations between continuous ANC and TILs were noted. Conclusion: Low peripheral ANC could be linked with LPBC, supporting the hypothesis that systemic immune cell counts might be associated with the tumor-immune microenvironment.",
author = "Yoon, {Chang Ik} and Soeun Park and Cha, {Yoon Jin} and Lee, {Hye Sun} and Bae, {Soong June} and Chihwan Cha and Lee, {Da Young} and Ahn, {Sung Gwe} and Joon Jeong",
year = "2019",
month = "1",
day = "1",
doi = "10.1016/j.breast.2019.09.013",
language = "English",
journal = "Breast",
issn = "0960-9776",
publisher = "Churchill Livingstone",

}

Associations between absolute neutrophil count and lymphocyte-predominant breast cancer. / Yoon, Chang Ik; Park, Soeun; Cha, Yoon Jin; Lee, Hye Sun; Bae, Soong June; Cha, Chihwan; Lee, Da Young; Ahn, Sung Gwe; Jeong, Joon.

In: Breast, 01.01.2019.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Associations between absolute neutrophil count and lymphocyte-predominant breast cancer

AU - Yoon, Chang Ik

AU - Park, Soeun

AU - Cha, Yoon Jin

AU - Lee, Hye Sun

AU - Bae, Soong June

AU - Cha, Chihwan

AU - Lee, Da Young

AU - Ahn, Sung Gwe

AU - Jeong, Joon

PY - 2019/1/1

Y1 - 2019/1/1

N2 - Introduction: Tumor-infiltrating lymphocytes (TILs) might be associated with host-cell mediated immunity, which could be partly reflected by peripheral blood cell counts. In addition, lymphocyte-predominant breast cancer (LPBC), which was defined as tumors having high TIL levels, showed a favorable prognosis among triple-negative breast cancer or HER2-positive breast cancer. We aimed to investigate whether peripheral blood cell counts are associated with LPBC. Methods: We evaluated the percentage of stromal TILs in breast cancer patients who underwent primary surgery, using the standardized methodology proposed by the international TIL Working Group. Lymphocyte-predominant breast cancer (LPBC) was defined as tumors having high TIL levels (≥50%). Peripheral blood cell counts including absolute neutrophil counts (ANC), absolute lymphocyte counts (ALC) and neutrophil-to-lymphocyte ratio (NLR) was obtained from pretreatment laboratory data. Result: Of the 810 patients, 132 (16.3%) had LPBC, and 678 (83.7%) had non-LBPC. In a comparison of 3 markers of peripheral blood counts, LPBC had a significantly lower mean ANC than non-LPBC (3,304 vs. 3,564; P = 0.023), but the other means were not different. In multivariable analysis, each 1K increment in ANC corresponded to an odds ratio of 0.790 (95% CI, 0.642 to 0.971) for LPBC. In the ER-negative and high-Ki67 subgroups identified by interaction tests, significant inverse correlations between continuous ANC and TILs were noted. Conclusion: Low peripheral ANC could be linked with LPBC, supporting the hypothesis that systemic immune cell counts might be associated with the tumor-immune microenvironment.

AB - Introduction: Tumor-infiltrating lymphocytes (TILs) might be associated with host-cell mediated immunity, which could be partly reflected by peripheral blood cell counts. In addition, lymphocyte-predominant breast cancer (LPBC), which was defined as tumors having high TIL levels, showed a favorable prognosis among triple-negative breast cancer or HER2-positive breast cancer. We aimed to investigate whether peripheral blood cell counts are associated with LPBC. Methods: We evaluated the percentage of stromal TILs in breast cancer patients who underwent primary surgery, using the standardized methodology proposed by the international TIL Working Group. Lymphocyte-predominant breast cancer (LPBC) was defined as tumors having high TIL levels (≥50%). Peripheral blood cell counts including absolute neutrophil counts (ANC), absolute lymphocyte counts (ALC) and neutrophil-to-lymphocyte ratio (NLR) was obtained from pretreatment laboratory data. Result: Of the 810 patients, 132 (16.3%) had LPBC, and 678 (83.7%) had non-LBPC. In a comparison of 3 markers of peripheral blood counts, LPBC had a significantly lower mean ANC than non-LPBC (3,304 vs. 3,564; P = 0.023), but the other means were not different. In multivariable analysis, each 1K increment in ANC corresponded to an odds ratio of 0.790 (95% CI, 0.642 to 0.971) for LPBC. In the ER-negative and high-Ki67 subgroups identified by interaction tests, significant inverse correlations between continuous ANC and TILs were noted. Conclusion: Low peripheral ANC could be linked with LPBC, supporting the hypothesis that systemic immune cell counts might be associated with the tumor-immune microenvironment.

UR - http://www.scopus.com/inward/record.url?scp=85073074250&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85073074250&partnerID=8YFLogxK

U2 - 10.1016/j.breast.2019.09.013

DO - 10.1016/j.breast.2019.09.013

M3 - Article

AN - SCOPUS:85073074250

JO - Breast

JF - Breast

SN - 0960-9776

ER -