Associations between cardio-ankle vascular index and microvascular complications in type 2 diabetes mellitus patients.

Kwang Joon Kim, Byung Wan Lee, Hyun Min Kim, Joo Youn Shin, Eun Seok Kang, Bong Soo Cha, Eun Jig Lee, Sung Kil Lim, Hyun Chul Lee

Research output: Contribution to journalArticle

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Abstract

Type 2 diabetes mellitus (T2DM) is a risk factor for increased arterial stiffness. We evaluated associations between the cardio-ankle vascular index (CAVI) and carotid plaque, intima media thickness (IMT), and diabetic microvascular complications in Korean T2DM patients. We conducted a retrospective, cross-sectional study of 320 Korean T2DM patients without a history of macrovascular disease or macroalbuminuria. We measured 24-hour urinary albumin excretion (UAE) levels and performed funduscopic and neuropathy examinations to assess the extent of diabetic microvascular complications. Arterial stiffness was assessed using CAVI. We also measured the ankle-brachial index (ABI), common carotid artery IMT, and carotid beta stiffness index. Among the 320 patients enrolled in this study, 64 (20%) had increased CAVI (≥ 9). We found that CAVI was correlated with systolic blood pressure, pulse pressure, IMT, carotid beta stiffness index, log-transformed UAE, and total cholesterol. In multiple logistic regression analysis, mean IMT and the presence of carotid plaque were independently associated with increased CAVI (≥ 9) (OR=5.77, P < 0.01; OR=5.36, P < 0.001, respectively). Furthermore, an increased CAVI was associated with peripheral neuropathy (OR=2.03, P = 0.03) and microalbuminuria (OR=2.47, P < 0.01) after adjusting for possible confounding variables. The results of this study suggest that increased CAVI is associated with the presence of arterial plaque, increased IMT, and microvascular complications, such as nephropathy and neuropathy, in T2DM patients.

Original languageEnglish
Pages (from-to)328-336
Number of pages9
JournalJournal of atherosclerosis and thrombosis
Volume18
Issue number4
DOIs
Publication statusPublished - 2011 Apr 27

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Medical problems
Ankle
Type 2 Diabetes Mellitus
Blood Vessels
Stiffness
Carotid Intima-Media Thickness
Albumins
Vascular Stiffness
Diabetes Complications
Blood Pressure
Blood pressure
Regression analysis
Logistics
Cholesterol
Ankle Brachial Index
Confounding Factors (Epidemiology)
Common Carotid Artery
Peripheral Nervous System Diseases
Cross-Sectional Studies
Logistic Models

All Science Journal Classification (ASJC) codes

  • Internal Medicine
  • Cardiology and Cardiovascular Medicine
  • Biochemistry, medical

Cite this

Kim, Kwang Joon ; Lee, Byung Wan ; Kim, Hyun Min ; Shin, Joo Youn ; Kang, Eun Seok ; Cha, Bong Soo ; Lee, Eun Jig ; Lim, Sung Kil ; Lee, Hyun Chul. / Associations between cardio-ankle vascular index and microvascular complications in type 2 diabetes mellitus patients. In: Journal of atherosclerosis and thrombosis. 2011 ; Vol. 18, No. 4. pp. 328-336.
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abstract = "Type 2 diabetes mellitus (T2DM) is a risk factor for increased arterial stiffness. We evaluated associations between the cardio-ankle vascular index (CAVI) and carotid plaque, intima media thickness (IMT), and diabetic microvascular complications in Korean T2DM patients. We conducted a retrospective, cross-sectional study of 320 Korean T2DM patients without a history of macrovascular disease or macroalbuminuria. We measured 24-hour urinary albumin excretion (UAE) levels and performed funduscopic and neuropathy examinations to assess the extent of diabetic microvascular complications. Arterial stiffness was assessed using CAVI. We also measured the ankle-brachial index (ABI), common carotid artery IMT, and carotid beta stiffness index. Among the 320 patients enrolled in this study, 64 (20{\%}) had increased CAVI (≥ 9). We found that CAVI was correlated with systolic blood pressure, pulse pressure, IMT, carotid beta stiffness index, log-transformed UAE, and total cholesterol. In multiple logistic regression analysis, mean IMT and the presence of carotid plaque were independently associated with increased CAVI (≥ 9) (OR=5.77, P < 0.01; OR=5.36, P < 0.001, respectively). Furthermore, an increased CAVI was associated with peripheral neuropathy (OR=2.03, P = 0.03) and microalbuminuria (OR=2.47, P < 0.01) after adjusting for possible confounding variables. The results of this study suggest that increased CAVI is associated with the presence of arterial plaque, increased IMT, and microvascular complications, such as nephropathy and neuropathy, in T2DM patients.",
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Associations between cardio-ankle vascular index and microvascular complications in type 2 diabetes mellitus patients. / Kim, Kwang Joon; Lee, Byung Wan; Kim, Hyun Min; Shin, Joo Youn; Kang, Eun Seok; Cha, Bong Soo; Lee, Eun Jig; Lim, Sung Kil; Lee, Hyun Chul.

In: Journal of atherosclerosis and thrombosis, Vol. 18, No. 4, 27.04.2011, p. 328-336.

Research output: Contribution to journalArticle

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AU - Lee, Byung Wan

AU - Kim, Hyun Min

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AU - Cha, Bong Soo

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AU - Lim, Sung Kil

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