Associations between elevated resting heart rate and subclinical atherosclerosis in asymptomatic Korean adults undergoing coronary artery calcium scoring

Donghee Han; Ji Hyun Lee; Asim Rizvi; Lohendran Baskaran; Hyo Eun Park; Su Yeon Choi; Eun Ju Chun; Jidong Sung; Sung Hak Park; Hae Won Han; James K. Min; Hyuk Jae Chang; Bríain ó Hartaigh

doi:10.1007/s10554-016-0944-7

Associations between elevated resting heart rate and subclinical atherosclerosis in asymptomatic Korean adults undergoing coronary artery calcium scoring

Donghee Han, Ji Hyun Lee, Asim Rizvi, Lohendran Baskaran, Hyo Eun Park, Su Yeon Choi, Eun Ju Chun, Jidong Sung, Sung Hak Park, Hae Won Han, James K. Min, Hyuk Jae Chang, Bríain ó Hartaigh

Department of Internal Medicine

Research output: Contribution to journal › Article › peer-review

2 Citations (Scopus)

Abstract

Elevated resting heart rate (RHR) and the presence of coronary artery calcium (CAC) are closely related with inflammatory activity and cardiovascular disease outcomes. To date, however, the relationship between a high RHR and CAC has not been well studied, especially in non-western populations. We therefore aimed to examine the cross-sectional relationship between high RHR and the burden of subclinical atherosclerosis as measured by CAC score in a large sample of Korean adults. A total 26,018 subjects were enrolled and underwent CAC screening as part of a broader general health examination. RHR was categorized into four groups as: <60, 60–69, 70–79, and ≥80 beats per minute. Multivariable logistic regression models were employed to estimate the odds of having a CAC score of either >0, >100, or >400 based on RHR. Mean age of the study population was 53.9 ± 8.2 years, and 79.7 % were male. After adjustment, each 10 beat per minute increment in RHR was associated with greater odds of having a CAC score above 100 (OR 1.13, 95 % CI 1.08–1.18) or 400 (OR 1.22, 95 % CI 1.13–1.31). Likewise, following adjustment, the odds of having a CAC >100 or >400 for those with a RHR ≥80 beats per minute were 1.42 (95 % CI 1.19–1.69) and 1.86 (95 % CI 1.42–2.47), respectively, compared with those who had a RHR <60 beats per minute. In a large cohort of Korean adults, elevations in the RHR, particularly above 80 beats per minute, were found to be independently associated with the presence of subclinical atherosclerosis as measured by CAC scoring.

Original language	English
Pages (from-to)	1587-1593
Number of pages	7
Journal	International Journal of Cardiovascular Imaging
Volume	32
Issue number	10
DOIs	https://doi.org/10.1007/s10554-016-0944-7
Publication status	Published - 2016 Oct 1

Bibliographical note

Funding Information:
This work was supported by Leading Foreign Research Institute Recruitment Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Science, ICT & Future Planning (MSIP; 2012027176) and funded in part by a generous gift from the Dalio Institute of Cardiovascular Imaging and the Michael Wolk Foundation.

Publisher Copyright:
© 2016, Springer Science+Business Media Dordrecht.

All Science Journal Classification (ASJC) codes

Radiology Nuclear Medicine and imaging
Cardiology and Cardiovascular Medicine

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1007/s10554-016-0944-7

Cite this

Han, D., Lee, J. H., Rizvi, A., Baskaran, L., Park, H. E., Choi, S. Y., Chun, E. J., Sung, J., Park, S. H., Han, H. W., Min, J. K., Chang, H. J., & ó Hartaigh, B. (2016). Associations between elevated resting heart rate and subclinical atherosclerosis in asymptomatic Korean adults undergoing coronary artery calcium scoring. International Journal of Cardiovascular Imaging, 32(10), 1587-1593. https://doi.org/10.1007/s10554-016-0944-7

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title = "Associations between elevated resting heart rate and subclinical atherosclerosis in asymptomatic Korean adults undergoing coronary artery calcium scoring",

abstract = "Elevated resting heart rate (RHR) and the presence of coronary artery calcium (CAC) are closely related with inflammatory activity and cardiovascular disease outcomes. To date, however, the relationship between a high RHR and CAC has not been well studied, especially in non-western populations. We therefore aimed to examine the cross-sectional relationship between high RHR and the burden of subclinical atherosclerosis as measured by CAC score in a large sample of Korean adults. A total 26,018 subjects were enrolled and underwent CAC screening as part of a broader general health examination. RHR was categorized into four groups as: <60, 60–69, 70–79, and ≥80 beats per minute. Multivariable logistic regression models were employed to estimate the odds of having a CAC score of either >0, >100, or >400 based on RHR. Mean age of the study population was 53.9 ± 8.2 years, and 79.7 % were male. After adjustment, each 10 beat per minute increment in RHR was associated with greater odds of having a CAC score above 100 (OR 1.13, 95 % CI 1.08–1.18) or 400 (OR 1.22, 95 % CI 1.13–1.31). Likewise, following adjustment, the odds of having a CAC >100 or >400 for those with a RHR ≥80 beats per minute were 1.42 (95 % CI 1.19–1.69) and 1.86 (95 % CI 1.42–2.47), respectively, compared with those who had a RHR <60 beats per minute. In a large cohort of Korean adults, elevations in the RHR, particularly above 80 beats per minute, were found to be independently associated with the presence of subclinical atherosclerosis as measured by CAC scoring.",

author = "Donghee Han and Lee, {Ji Hyun} and Asim Rizvi and Lohendran Baskaran and Park, {Hyo Eun} and Choi, {Su Yeon} and Chun, {Eun Ju} and Jidong Sung and Park, {Sung Hak} and Han, {Hae Won} and Min, {James K.} and Chang, {Hyuk Jae} and {{\'o} Hartaigh}, Br{\'i}ain",

note = "Funding Information: This work was supported by Leading Foreign Research Institute Recruitment Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Science, ICT & Future Planning (MSIP; 2012027176) and funded in part by a generous gift from the Dalio Institute of Cardiovascular Imaging and the Michael Wolk Foundation. Publisher Copyright: {\textcopyright} 2016, Springer Science+Business Media Dordrecht.",

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doi = "10.1007/s10554-016-0944-7",

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Han, D, Lee, JH, Rizvi, A, Baskaran, L, Park, HE, Choi, SY, Chun, EJ, Sung, J, Park, SH, Han, HW, Min, JK, Chang, HJ & ó Hartaigh, B 2016, 'Associations between elevated resting heart rate and subclinical atherosclerosis in asymptomatic Korean adults undergoing coronary artery calcium scoring', International Journal of Cardiovascular Imaging, vol. 32, no. 10, pp. 1587-1593. https://doi.org/10.1007/s10554-016-0944-7

TY - JOUR

T1 - Associations between elevated resting heart rate and subclinical atherosclerosis in asymptomatic Korean adults undergoing coronary artery calcium scoring

AU - Han, Donghee

AU - Lee, Ji Hyun

AU - Rizvi, Asim

AU - Baskaran, Lohendran

AU - Park, Hyo Eun

AU - Choi, Su Yeon

AU - Chun, Eun Ju

AU - Sung, Jidong

AU - Park, Sung Hak

AU - Han, Hae Won

AU - Min, James K.

AU - Chang, Hyuk Jae

AU - ó Hartaigh, Bríain

N1 - Funding Information: This work was supported by Leading Foreign Research Institute Recruitment Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Science, ICT & Future Planning (MSIP; 2012027176) and funded in part by a generous gift from the Dalio Institute of Cardiovascular Imaging and the Michael Wolk Foundation. Publisher Copyright: © 2016, Springer Science+Business Media Dordrecht.

PY - 2016/10/1

Y1 - 2016/10/1

N2 - Elevated resting heart rate (RHR) and the presence of coronary artery calcium (CAC) are closely related with inflammatory activity and cardiovascular disease outcomes. To date, however, the relationship between a high RHR and CAC has not been well studied, especially in non-western populations. We therefore aimed to examine the cross-sectional relationship between high RHR and the burden of subclinical atherosclerosis as measured by CAC score in a large sample of Korean adults. A total 26,018 subjects were enrolled and underwent CAC screening as part of a broader general health examination. RHR was categorized into four groups as: <60, 60–69, 70–79, and ≥80 beats per minute. Multivariable logistic regression models were employed to estimate the odds of having a CAC score of either >0, >100, or >400 based on RHR. Mean age of the study population was 53.9 ± 8.2 years, and 79.7 % were male. After adjustment, each 10 beat per minute increment in RHR was associated with greater odds of having a CAC score above 100 (OR 1.13, 95 % CI 1.08–1.18) or 400 (OR 1.22, 95 % CI 1.13–1.31). Likewise, following adjustment, the odds of having a CAC >100 or >400 for those with a RHR ≥80 beats per minute were 1.42 (95 % CI 1.19–1.69) and 1.86 (95 % CI 1.42–2.47), respectively, compared with those who had a RHR <60 beats per minute. In a large cohort of Korean adults, elevations in the RHR, particularly above 80 beats per minute, were found to be independently associated with the presence of subclinical atherosclerosis as measured by CAC scoring.

AB - Elevated resting heart rate (RHR) and the presence of coronary artery calcium (CAC) are closely related with inflammatory activity and cardiovascular disease outcomes. To date, however, the relationship between a high RHR and CAC has not been well studied, especially in non-western populations. We therefore aimed to examine the cross-sectional relationship between high RHR and the burden of subclinical atherosclerosis as measured by CAC score in a large sample of Korean adults. A total 26,018 subjects were enrolled and underwent CAC screening as part of a broader general health examination. RHR was categorized into four groups as: <60, 60–69, 70–79, and ≥80 beats per minute. Multivariable logistic regression models were employed to estimate the odds of having a CAC score of either >0, >100, or >400 based on RHR. Mean age of the study population was 53.9 ± 8.2 years, and 79.7 % were male. After adjustment, each 10 beat per minute increment in RHR was associated with greater odds of having a CAC score above 100 (OR 1.13, 95 % CI 1.08–1.18) or 400 (OR 1.22, 95 % CI 1.13–1.31). Likewise, following adjustment, the odds of having a CAC >100 or >400 for those with a RHR ≥80 beats per minute were 1.42 (95 % CI 1.19–1.69) and 1.86 (95 % CI 1.42–2.47), respectively, compared with those who had a RHR <60 beats per minute. In a large cohort of Korean adults, elevations in the RHR, particularly above 80 beats per minute, were found to be independently associated with the presence of subclinical atherosclerosis as measured by CAC scoring.

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Associations between elevated resting heart rate and subclinical atherosclerosis in asymptomatic Korean adults undergoing coronary artery calcium scoring

Abstract

Bibliographical note

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UN SDGs

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