Associations Between Estimated Desaturase Activity and Insulin Resistance in Korean Boys

Young Sim Choi, Han Byul Jang, Ju Yeon Park, Hye Ja Lee, Jae Heon Kang, Kyung Hee Park, Jong Ho Lee, Sang Ick Park, Jihyun Song

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Objectives: Obesity in childhood increases the risk of obesity in adulthood, and is predictive of the development of metabolic disorders. The fatty acid compositions of various tissues, including blood, are associated with obesity and obesity-associated disorders. Thus, tracking plasma phospholipid (PL) features and metabolic parameters in young individuals may strengthen the utility of fatty acid composition as an early biomarker of future metabolic disorders. Methods: Anthropometric and blood biochemical data were obtained from 131 Korean males aged 10.5±0.4 years, and followed up at 2 years. We analyzed the plasma PL fatty acids according to obesity. Obese children were defined as those with a body mass index (BMI) greater than the 85th percentile for age and gender, based on Korean child growth standards. Results: Activities of lipid desaturases, stearyl-CoAD (SCD-16,16:1n-7/16:0), delta-6D (D6D, 20:3n-6/18:2n-6), and delta-5D (D5D, 20:4n-6/20:3n-6), were estimated. Obese individuals had significantly higher proportions of palmitoleic acid (16:1n-7) and dihomo-gamma linolenic acid (DGLA, 20:3n-6) at both baseline and follow-up than did lean individuals. The activities of SCD-16 and D6D were higher in obese than lean boys. The baseline SCD-16 activity level was positively associated with the baseline waist circumference (WC) and the metabolic risk score. The baseline D6D level was positively associated with WC and also with the homeostasis model of assessment of insulin resistance (HOMA-IR), a surrogate marker of insulin resistance (IR), and metabolic risk score at both baseline and follow-up. Conclusion: In young Korean males, higher D6D activity predicts the future development of IR and associated metabolic disorders including dyslipidemia.

Original languageEnglish
Pages (from-to)251-257
Number of pages7
JournalOsong Public Health and Research Perspectives
Volume5
Issue number5
DOIs
Publication statusPublished - 2014 Jan 1

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Insulin Resistance
Obesity
Fatty Acids
Waist Circumference
Phospholipids
8,11,14-Eicosatrienoic Acid
Biomarkers
Pediatric Obesity
Dyslipidemias
Body Mass Index
Homeostasis
Lipids
Growth

All Science Journal Classification (ASJC) codes

  • Public Health, Environmental and Occupational Health
  • Infectious Diseases

Cite this

Choi, Y. S., Jang, H. B., Park, J. Y., Lee, H. J., Kang, J. H., Park, K. H., ... Song, J. (2014). Associations Between Estimated Desaturase Activity and Insulin Resistance in Korean Boys. Osong Public Health and Research Perspectives, 5(5), 251-257. https://doi.org/10.1016/j.phrp.2014.08.008
Choi, Young Sim ; Jang, Han Byul ; Park, Ju Yeon ; Lee, Hye Ja ; Kang, Jae Heon ; Park, Kyung Hee ; Lee, Jong Ho ; Park, Sang Ick ; Song, Jihyun. / Associations Between Estimated Desaturase Activity and Insulin Resistance in Korean Boys. In: Osong Public Health and Research Perspectives. 2014 ; Vol. 5, No. 5. pp. 251-257.
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Associations Between Estimated Desaturase Activity and Insulin Resistance in Korean Boys. / Choi, Young Sim; Jang, Han Byul; Park, Ju Yeon; Lee, Hye Ja; Kang, Jae Heon; Park, Kyung Hee; Lee, Jong Ho; Park, Sang Ick; Song, Jihyun.

In: Osong Public Health and Research Perspectives, Vol. 5, No. 5, 01.01.2014, p. 251-257.

Research output: Contribution to journalArticle

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T1 - Associations Between Estimated Desaturase Activity and Insulin Resistance in Korean Boys

AU - Choi, Young Sim

AU - Jang, Han Byul

AU - Park, Ju Yeon

AU - Lee, Hye Ja

AU - Kang, Jae Heon

AU - Park, Kyung Hee

AU - Lee, Jong Ho

AU - Park, Sang Ick

AU - Song, Jihyun

PY - 2014/1/1

Y1 - 2014/1/1

N2 - Objectives: Obesity in childhood increases the risk of obesity in adulthood, and is predictive of the development of metabolic disorders. The fatty acid compositions of various tissues, including blood, are associated with obesity and obesity-associated disorders. Thus, tracking plasma phospholipid (PL) features and metabolic parameters in young individuals may strengthen the utility of fatty acid composition as an early biomarker of future metabolic disorders. Methods: Anthropometric and blood biochemical data were obtained from 131 Korean males aged 10.5±0.4 years, and followed up at 2 years. We analyzed the plasma PL fatty acids according to obesity. Obese children were defined as those with a body mass index (BMI) greater than the 85th percentile for age and gender, based on Korean child growth standards. Results: Activities of lipid desaturases, stearyl-CoAD (SCD-16,16:1n-7/16:0), delta-6D (D6D, 20:3n-6/18:2n-6), and delta-5D (D5D, 20:4n-6/20:3n-6), were estimated. Obese individuals had significantly higher proportions of palmitoleic acid (16:1n-7) and dihomo-gamma linolenic acid (DGLA, 20:3n-6) at both baseline and follow-up than did lean individuals. The activities of SCD-16 and D6D were higher in obese than lean boys. The baseline SCD-16 activity level was positively associated with the baseline waist circumference (WC) and the metabolic risk score. The baseline D6D level was positively associated with WC and also with the homeostasis model of assessment of insulin resistance (HOMA-IR), a surrogate marker of insulin resistance (IR), and metabolic risk score at both baseline and follow-up. Conclusion: In young Korean males, higher D6D activity predicts the future development of IR and associated metabolic disorders including dyslipidemia.

AB - Objectives: Obesity in childhood increases the risk of obesity in adulthood, and is predictive of the development of metabolic disorders. The fatty acid compositions of various tissues, including blood, are associated with obesity and obesity-associated disorders. Thus, tracking plasma phospholipid (PL) features and metabolic parameters in young individuals may strengthen the utility of fatty acid composition as an early biomarker of future metabolic disorders. Methods: Anthropometric and blood biochemical data were obtained from 131 Korean males aged 10.5±0.4 years, and followed up at 2 years. We analyzed the plasma PL fatty acids according to obesity. Obese children were defined as those with a body mass index (BMI) greater than the 85th percentile for age and gender, based on Korean child growth standards. Results: Activities of lipid desaturases, stearyl-CoAD (SCD-16,16:1n-7/16:0), delta-6D (D6D, 20:3n-6/18:2n-6), and delta-5D (D5D, 20:4n-6/20:3n-6), were estimated. Obese individuals had significantly higher proportions of palmitoleic acid (16:1n-7) and dihomo-gamma linolenic acid (DGLA, 20:3n-6) at both baseline and follow-up than did lean individuals. The activities of SCD-16 and D6D were higher in obese than lean boys. The baseline SCD-16 activity level was positively associated with the baseline waist circumference (WC) and the metabolic risk score. The baseline D6D level was positively associated with WC and also with the homeostasis model of assessment of insulin resistance (HOMA-IR), a surrogate marker of insulin resistance (IR), and metabolic risk score at both baseline and follow-up. Conclusion: In young Korean males, higher D6D activity predicts the future development of IR and associated metabolic disorders including dyslipidemia.

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