Associations between fatness, fitness, IGF and IMT among obese Korean male adolescents

Eun Sung Kim, Ji Hye Park, Mi Kyung Lee, Dong Hoon Lee, Eun Seok Kang, Hyun Chul Lee, Yoonsuk Jekal, Justin Y. Jeon

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

Background: The purpose of this study was to investigate the association between obesity, fitness levels and cardiovascular (CVD) risk factors, and to identify the correlation between of insulin-like growth factor (IGF)-1, IGF binding protein-3 (IGFBP-3), and carotid intima media thickness (IMT) in Korean adolescents. Methods: A total of 225 high school males with a mean age of 16.96±0.23 years participated in this study, and their fatness and fitness levels, fasting glucose, fasting insulin, homeostasis model assessment of insulin resistance (HOMA-IR), blood lipids, IGF-1, IGFBP-3, and IMT were measured. Results: The results showed that total cholesterol (TC), triglyceride (TG), high density lipoprotein cholesterol (HDL-C), fasting insulin, HOMA-IR, IGF-1, and IGFBP-3 levels were significantly higher in the most obese group than in the other two groups (tertiles). Muscular and cardiopulmonary fitness were negatively associated with weight, body mass index (BMI), fat mass, body fat, waist circumference (WC), fasting insulin, HOMA-IR, and IMT. IGF-1 and IGFBP-3 levels were correlated with WC, hip circumference (HC), fasting glucose, TG, HDL-C, fasting insulin, and HOMA-IR. IMT levels were significantly associated with weight, BMI, muscle mass, fat mass, percent body fat, WC, HC, systolic blood pressure, diastolic blood pressure and high-sensitivity C-reactive protein. Conclusion: There was a significant association between increased obesity and decreased fitness and HOMA-IR, IGF, and IMT among adolescents.

Original languageEnglish
Pages (from-to)610-618
Number of pages9
JournalDiabetes and Metabolism Journal
Volume35
Issue number6
DOIs
Publication statusPublished - 2011 Dec 1

Fingerprint

Somatomedins
Fasting
Insulin-Like Growth Factor Binding Protein 3
Insulin Resistance
Homeostasis
Waist Circumference
Insulin
Blood Pressure
HDL Cholesterol
Adipose Tissue
Hip
Triglycerides
Body Mass Index
Obesity
Fats
Weights and Measures
Glucose
Insulin-Like Growth Factor Binding Proteins
Carotid Intima-Media Thickness
C-Reactive Protein

All Science Journal Classification (ASJC) codes

  • Endocrinology, Diabetes and Metabolism

Cite this

Kim, Eun Sung ; Park, Ji Hye ; Lee, Mi Kyung ; Lee, Dong Hoon ; Kang, Eun Seok ; Lee, Hyun Chul ; Jekal, Yoonsuk ; Jeon, Justin Y. / Associations between fatness, fitness, IGF and IMT among obese Korean male adolescents. In: Diabetes and Metabolism Journal. 2011 ; Vol. 35, No. 6. pp. 610-618.
@article{a71ed9fc898a4a5085df59539f8b7ef7,
title = "Associations between fatness, fitness, IGF and IMT among obese Korean male adolescents",
abstract = "Background: The purpose of this study was to investigate the association between obesity, fitness levels and cardiovascular (CVD) risk factors, and to identify the correlation between of insulin-like growth factor (IGF)-1, IGF binding protein-3 (IGFBP-3), and carotid intima media thickness (IMT) in Korean adolescents. Methods: A total of 225 high school males with a mean age of 16.96±0.23 years participated in this study, and their fatness and fitness levels, fasting glucose, fasting insulin, homeostasis model assessment of insulin resistance (HOMA-IR), blood lipids, IGF-1, IGFBP-3, and IMT were measured. Results: The results showed that total cholesterol (TC), triglyceride (TG), high density lipoprotein cholesterol (HDL-C), fasting insulin, HOMA-IR, IGF-1, and IGFBP-3 levels were significantly higher in the most obese group than in the other two groups (tertiles). Muscular and cardiopulmonary fitness were negatively associated with weight, body mass index (BMI), fat mass, body fat, waist circumference (WC), fasting insulin, HOMA-IR, and IMT. IGF-1 and IGFBP-3 levels were correlated with WC, hip circumference (HC), fasting glucose, TG, HDL-C, fasting insulin, and HOMA-IR. IMT levels were significantly associated with weight, BMI, muscle mass, fat mass, percent body fat, WC, HC, systolic blood pressure, diastolic blood pressure and high-sensitivity C-reactive protein. Conclusion: There was a significant association between increased obesity and decreased fitness and HOMA-IR, IGF, and IMT among adolescents.",
author = "Kim, {Eun Sung} and Park, {Ji Hye} and Lee, {Mi Kyung} and Lee, {Dong Hoon} and Kang, {Eun Seok} and Lee, {Hyun Chul} and Yoonsuk Jekal and Jeon, {Justin Y.}",
year = "2011",
month = "12",
day = "1",
doi = "10.4093/dmj.2011.35.6.610",
language = "English",
volume = "35",
pages = "610--618",
journal = "Diabetes and Metabolism Journal",
issn = "2233-6079",
publisher = "Korean Diabetes Association",
number = "6",

}

Associations between fatness, fitness, IGF and IMT among obese Korean male adolescents. / Kim, Eun Sung; Park, Ji Hye; Lee, Mi Kyung; Lee, Dong Hoon; Kang, Eun Seok; Lee, Hyun Chul; Jekal, Yoonsuk; Jeon, Justin Y.

In: Diabetes and Metabolism Journal, Vol. 35, No. 6, 01.12.2011, p. 610-618.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Associations between fatness, fitness, IGF and IMT among obese Korean male adolescents

AU - Kim, Eun Sung

AU - Park, Ji Hye

AU - Lee, Mi Kyung

AU - Lee, Dong Hoon

AU - Kang, Eun Seok

AU - Lee, Hyun Chul

AU - Jekal, Yoonsuk

AU - Jeon, Justin Y.

PY - 2011/12/1

Y1 - 2011/12/1

N2 - Background: The purpose of this study was to investigate the association between obesity, fitness levels and cardiovascular (CVD) risk factors, and to identify the correlation between of insulin-like growth factor (IGF)-1, IGF binding protein-3 (IGFBP-3), and carotid intima media thickness (IMT) in Korean adolescents. Methods: A total of 225 high school males with a mean age of 16.96±0.23 years participated in this study, and their fatness and fitness levels, fasting glucose, fasting insulin, homeostasis model assessment of insulin resistance (HOMA-IR), blood lipids, IGF-1, IGFBP-3, and IMT were measured. Results: The results showed that total cholesterol (TC), triglyceride (TG), high density lipoprotein cholesterol (HDL-C), fasting insulin, HOMA-IR, IGF-1, and IGFBP-3 levels were significantly higher in the most obese group than in the other two groups (tertiles). Muscular and cardiopulmonary fitness were negatively associated with weight, body mass index (BMI), fat mass, body fat, waist circumference (WC), fasting insulin, HOMA-IR, and IMT. IGF-1 and IGFBP-3 levels were correlated with WC, hip circumference (HC), fasting glucose, TG, HDL-C, fasting insulin, and HOMA-IR. IMT levels were significantly associated with weight, BMI, muscle mass, fat mass, percent body fat, WC, HC, systolic blood pressure, diastolic blood pressure and high-sensitivity C-reactive protein. Conclusion: There was a significant association between increased obesity and decreased fitness and HOMA-IR, IGF, and IMT among adolescents.

AB - Background: The purpose of this study was to investigate the association between obesity, fitness levels and cardiovascular (CVD) risk factors, and to identify the correlation between of insulin-like growth factor (IGF)-1, IGF binding protein-3 (IGFBP-3), and carotid intima media thickness (IMT) in Korean adolescents. Methods: A total of 225 high school males with a mean age of 16.96±0.23 years participated in this study, and their fatness and fitness levels, fasting glucose, fasting insulin, homeostasis model assessment of insulin resistance (HOMA-IR), blood lipids, IGF-1, IGFBP-3, and IMT were measured. Results: The results showed that total cholesterol (TC), triglyceride (TG), high density lipoprotein cholesterol (HDL-C), fasting insulin, HOMA-IR, IGF-1, and IGFBP-3 levels were significantly higher in the most obese group than in the other two groups (tertiles). Muscular and cardiopulmonary fitness were negatively associated with weight, body mass index (BMI), fat mass, body fat, waist circumference (WC), fasting insulin, HOMA-IR, and IMT. IGF-1 and IGFBP-3 levels were correlated with WC, hip circumference (HC), fasting glucose, TG, HDL-C, fasting insulin, and HOMA-IR. IMT levels were significantly associated with weight, BMI, muscle mass, fat mass, percent body fat, WC, HC, systolic blood pressure, diastolic blood pressure and high-sensitivity C-reactive protein. Conclusion: There was a significant association between increased obesity and decreased fitness and HOMA-IR, IGF, and IMT among adolescents.

UR - http://www.scopus.com/inward/record.url?scp=84864793865&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84864793865&partnerID=8YFLogxK

U2 - 10.4093/dmj.2011.35.6.610

DO - 10.4093/dmj.2011.35.6.610

M3 - Article

C2 - 22247904

AN - SCOPUS:84864793865

VL - 35

SP - 610

EP - 618

JO - Diabetes and Metabolism Journal

JF - Diabetes and Metabolism Journal

SN - 2233-6079

IS - 6

ER -