Associations between lipid profiles of adolescents and their mothers based on a nationwide health and nutrition survey in South Korea

Ji Hyung Nam, Jaeyong Shin, Sung In Jang, Ji Hyun Kim, Kyu Tae Han, Jun Kyu Lee, Yun Jeong Lim, Eun Cheol Park

Research output: Contribution to journalArticle

Abstract

Objectives Dyslipidaemia is a metabolic disease influenced by environmental and genetic factors. Especially, family history related to genetic background is a strong risk factor of lipid abnormality. The aim of this study is to evaluate the association between the lipid profiles of adolescents and their mothers. Design A cross-sectional study. Setting The data were derived from the Korea National Health and Nutrition Examination Survey (IV-VI) between 2009 and 2015. Participants 2884 adolescents aged 12-18 years and their mothers were included. Primary outcome measures Outcome variables were adolescents' lipid levels. Mothers' lipid levels were the interesting variables. The lipid profiles included total cholesterol (TC), triglyceride (TG), high-density lipoprotein cholesterol (HDL-C) and low-density lipoprotein cholesterol (LDL-C). We identified partial correlation coefficients (r) between the lipids. Multiple linear regressions were performed to identify the amount of change in adolescents' lipid levels for each unit increase of their mothers' lipids. The regression models included various clinical characteristics and health behavioural factors of both adolescents and mothers. Results The mean levels of adolescents' lipids were 156.6, 83.6, 50.4 and 89.4 mg/dL, respectively for TC, TG, HDL-C and LDL-C. Positive correlations between lipid levels of adolescents and mothers were observed for TC, TG, HDL-C and LDL-C (r, 95% CI: 0.271, 0.236 to 0.304; 0.204, 0.169 to 0.239; 0.289, 0.255 to 0.322; and 0.286, 0.252 to 0.319). The adolescent TC level was increased by 0.23 mg/dL for each unit increase of the mother's TC (SE, 0.02; p<0.001). The beta coefficients were 0.16 (SE, 0.01), 0.24 (SE, 0.02) and 0.24 (SE, 0.02), respectively, in each model of TG, HDL-C and LDL-C (all p<0.001). The linear relationships were significant regardless of sex and mother's characteristics. Conclusions Mothers' lipid levels are associated with adolescents' lipids; therefore, they can serve as a reference for the screening of adolescent's dyslipidaemia.

Original languageEnglish
Article numbere024731
JournalBMJ open
Volume9
Issue number3
DOIs
Publication statusPublished - 2019 Mar 1

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Republic of Korea
Nutrition Surveys
Health Surveys
Mothers
Lipids
Cholesterol
HDL Cholesterol
Triglycerides
LDL Cholesterol
Dyslipidemias
Metabolic Diseases
Korea
Sex Characteristics
Linear Models
Cross-Sectional Studies

All Science Journal Classification (ASJC) codes

  • Medicine(all)

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Nam, Ji Hyung ; Shin, Jaeyong ; Jang, Sung In ; Kim, Ji Hyun ; Han, Kyu Tae ; Lee, Jun Kyu ; Lim, Yun Jeong ; Park, Eun Cheol. / Associations between lipid profiles of adolescents and their mothers based on a nationwide health and nutrition survey in South Korea. In: BMJ open. 2019 ; Vol. 9, No. 3.
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title = "Associations between lipid profiles of adolescents and their mothers based on a nationwide health and nutrition survey in South Korea",
abstract = "Objectives Dyslipidaemia is a metabolic disease influenced by environmental and genetic factors. Especially, family history related to genetic background is a strong risk factor of lipid abnormality. The aim of this study is to evaluate the association between the lipid profiles of adolescents and their mothers. Design A cross-sectional study. Setting The data were derived from the Korea National Health and Nutrition Examination Survey (IV-VI) between 2009 and 2015. Participants 2884 adolescents aged 12-18 years and their mothers were included. Primary outcome measures Outcome variables were adolescents' lipid levels. Mothers' lipid levels were the interesting variables. The lipid profiles included total cholesterol (TC), triglyceride (TG), high-density lipoprotein cholesterol (HDL-C) and low-density lipoprotein cholesterol (LDL-C). We identified partial correlation coefficients (r) between the lipids. Multiple linear regressions were performed to identify the amount of change in adolescents' lipid levels for each unit increase of their mothers' lipids. The regression models included various clinical characteristics and health behavioural factors of both adolescents and mothers. Results The mean levels of adolescents' lipids were 156.6, 83.6, 50.4 and 89.4 mg/dL, respectively for TC, TG, HDL-C and LDL-C. Positive correlations between lipid levels of adolescents and mothers were observed for TC, TG, HDL-C and LDL-C (r, 95{\%} CI: 0.271, 0.236 to 0.304; 0.204, 0.169 to 0.239; 0.289, 0.255 to 0.322; and 0.286, 0.252 to 0.319). The adolescent TC level was increased by 0.23 mg/dL for each unit increase of the mother's TC (SE, 0.02; p<0.001). The beta coefficients were 0.16 (SE, 0.01), 0.24 (SE, 0.02) and 0.24 (SE, 0.02), respectively, in each model of TG, HDL-C and LDL-C (all p<0.001). The linear relationships were significant regardless of sex and mother's characteristics. Conclusions Mothers' lipid levels are associated with adolescents' lipids; therefore, they can serve as a reference for the screening of adolescent's dyslipidaemia.",
author = "Nam, {Ji Hyung} and Jaeyong Shin and Jang, {Sung In} and Kim, {Ji Hyun} and Han, {Kyu Tae} and Lee, {Jun Kyu} and Lim, {Yun Jeong} and Park, {Eun Cheol}",
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Associations between lipid profiles of adolescents and their mothers based on a nationwide health and nutrition survey in South Korea. / Nam, Ji Hyung; Shin, Jaeyong; Jang, Sung In; Kim, Ji Hyun; Han, Kyu Tae; Lee, Jun Kyu; Lim, Yun Jeong; Park, Eun Cheol.

In: BMJ open, Vol. 9, No. 3, e024731, 01.03.2019.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Associations between lipid profiles of adolescents and their mothers based on a nationwide health and nutrition survey in South Korea

AU - Nam, Ji Hyung

AU - Shin, Jaeyong

AU - Jang, Sung In

AU - Kim, Ji Hyun

AU - Han, Kyu Tae

AU - Lee, Jun Kyu

AU - Lim, Yun Jeong

AU - Park, Eun Cheol

PY - 2019/3/1

Y1 - 2019/3/1

N2 - Objectives Dyslipidaemia is a metabolic disease influenced by environmental and genetic factors. Especially, family history related to genetic background is a strong risk factor of lipid abnormality. The aim of this study is to evaluate the association between the lipid profiles of adolescents and their mothers. Design A cross-sectional study. Setting The data were derived from the Korea National Health and Nutrition Examination Survey (IV-VI) between 2009 and 2015. Participants 2884 adolescents aged 12-18 years and their mothers were included. Primary outcome measures Outcome variables were adolescents' lipid levels. Mothers' lipid levels were the interesting variables. The lipid profiles included total cholesterol (TC), triglyceride (TG), high-density lipoprotein cholesterol (HDL-C) and low-density lipoprotein cholesterol (LDL-C). We identified partial correlation coefficients (r) between the lipids. Multiple linear regressions were performed to identify the amount of change in adolescents' lipid levels for each unit increase of their mothers' lipids. The regression models included various clinical characteristics and health behavioural factors of both adolescents and mothers. Results The mean levels of adolescents' lipids were 156.6, 83.6, 50.4 and 89.4 mg/dL, respectively for TC, TG, HDL-C and LDL-C. Positive correlations between lipid levels of adolescents and mothers were observed for TC, TG, HDL-C and LDL-C (r, 95% CI: 0.271, 0.236 to 0.304; 0.204, 0.169 to 0.239; 0.289, 0.255 to 0.322; and 0.286, 0.252 to 0.319). The adolescent TC level was increased by 0.23 mg/dL for each unit increase of the mother's TC (SE, 0.02; p<0.001). The beta coefficients were 0.16 (SE, 0.01), 0.24 (SE, 0.02) and 0.24 (SE, 0.02), respectively, in each model of TG, HDL-C and LDL-C (all p<0.001). The linear relationships were significant regardless of sex and mother's characteristics. Conclusions Mothers' lipid levels are associated with adolescents' lipids; therefore, they can serve as a reference for the screening of adolescent's dyslipidaemia.

AB - Objectives Dyslipidaemia is a metabolic disease influenced by environmental and genetic factors. Especially, family history related to genetic background is a strong risk factor of lipid abnormality. The aim of this study is to evaluate the association between the lipid profiles of adolescents and their mothers. Design A cross-sectional study. Setting The data were derived from the Korea National Health and Nutrition Examination Survey (IV-VI) between 2009 and 2015. Participants 2884 adolescents aged 12-18 years and their mothers were included. Primary outcome measures Outcome variables were adolescents' lipid levels. Mothers' lipid levels were the interesting variables. The lipid profiles included total cholesterol (TC), triglyceride (TG), high-density lipoprotein cholesterol (HDL-C) and low-density lipoprotein cholesterol (LDL-C). We identified partial correlation coefficients (r) between the lipids. Multiple linear regressions were performed to identify the amount of change in adolescents' lipid levels for each unit increase of their mothers' lipids. The regression models included various clinical characteristics and health behavioural factors of both adolescents and mothers. Results The mean levels of adolescents' lipids were 156.6, 83.6, 50.4 and 89.4 mg/dL, respectively for TC, TG, HDL-C and LDL-C. Positive correlations between lipid levels of adolescents and mothers were observed for TC, TG, HDL-C and LDL-C (r, 95% CI: 0.271, 0.236 to 0.304; 0.204, 0.169 to 0.239; 0.289, 0.255 to 0.322; and 0.286, 0.252 to 0.319). The adolescent TC level was increased by 0.23 mg/dL for each unit increase of the mother's TC (SE, 0.02; p<0.001). The beta coefficients were 0.16 (SE, 0.01), 0.24 (SE, 0.02) and 0.24 (SE, 0.02), respectively, in each model of TG, HDL-C and LDL-C (all p<0.001). The linear relationships were significant regardless of sex and mother's characteristics. Conclusions Mothers' lipid levels are associated with adolescents' lipids; therefore, they can serve as a reference for the screening of adolescent's dyslipidaemia.

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