Associations of matrix metalloproteinase (MMP)-8; MMP-9; and their inhibitor, tissue inhibitor of metalloproteinase-1, with obesity-related biomarkers in apparently healthy adolescent boys

Youn Ho Shin, Ki Eun Kim, Yongjae Lee, Jae Hwan Nam, Young Mi Hong, Hye Jung Shin

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Purpose: Matrix metalloproteinases (MMPs) have been implicated in atherosclerosis, and therefore, are considered risk factors for metabolic dysfunction in adults. However, there is little data regarding circulating levels of MMPs and tissue inhibitors of MMPs (TIMPs) in the general adolescent population with regard to obesity-related biomarkers. In the present study, we determined the associations of MMP-8, MMP-9, and TIMP-1 levels and MMP-8/TIMP-1 and MMP-9/TIMP-1 ratios with obesity-related biomarkers in apparently healthy adolescent boys. Methods: We measured MMP and TIMP concentrations in plasma samples using the enzyme-linked immunosorbent assay and analyzed their associations with obesity-related biomarkers, such as liver enzymes and lipid profiles, in a sample of 91 Korean boys aged 13–14 years who participated in a general health check-up. Results: The mean age of the boys was 13.8±0.3 years; 72 boys were normal weight and 19 were overweight/obese. The Pearson correlation coefficients revealed a significant correlation between MMP-8 and aspartate aminotransferase (r=0.217, P =0.039) and alanine aminotransferase (r=0.250, P =0.017) and between TIMP-1 and aspartate aminotransferase (r=0.267, P =0.011). In a multivariate linear regression analysis, serum alanine aminotransferase was positively associated with the MMP-8 level. There were no significant differences in the MMP-8, MMP-9, and TIMP-1 levels or MMP-8/TIMP-1 and MMP-9/TIMP-1 ratios between control and overweight/obese subjects. Conclusion: We found a significant association between the MMP-8 level and alanine aminotransferase in the apparently healthy adolescent boys. These findings indicate that there may be a pathophysiological mechanism underlying the relationship between MMP-8 and liver enzymes in young adolescents.

Original languageEnglish
Pages (from-to)526-532
Number of pages7
JournalKorean Journal of Pediatrics
Volume57
Issue number12
DOIs
Publication statusPublished - 2014 Dec 15

Fingerprint

Matrix Metalloproteinase 8
Tissue Inhibitor of Metalloproteinase-1
Matrix Metalloproteinase 9
Matrix Metalloproteinase Inhibitors
Obesity
Biomarkers
Matrix Metalloproteinase 1
Matrix Metalloproteinases
Alanine Transaminase
Aspartate Aminotransferases
Tissue Inhibitor of Metalloproteinases
Liver
Enzymes
Linear Models
Atherosclerosis
Enzyme-Linked Immunosorbent Assay
Regression Analysis
Lipids
Weights and Measures

All Science Journal Classification (ASJC) codes

  • Pediatrics, Perinatology, and Child Health
  • Pediatrics

Cite this

@article{11f1c313f71e4efb8e356f1481e31970,
title = "Associations of matrix metalloproteinase (MMP)-8; MMP-9; and their inhibitor, tissue inhibitor of metalloproteinase-1, with obesity-related biomarkers in apparently healthy adolescent boys",
abstract = "Purpose: Matrix metalloproteinases (MMPs) have been implicated in atherosclerosis, and therefore, are considered risk factors for metabolic dysfunction in adults. However, there is little data regarding circulating levels of MMPs and tissue inhibitors of MMPs (TIMPs) in the general adolescent population with regard to obesity-related biomarkers. In the present study, we determined the associations of MMP-8, MMP-9, and TIMP-1 levels and MMP-8/TIMP-1 and MMP-9/TIMP-1 ratios with obesity-related biomarkers in apparently healthy adolescent boys. Methods: We measured MMP and TIMP concentrations in plasma samples using the enzyme-linked immunosorbent assay and analyzed their associations with obesity-related biomarkers, such as liver enzymes and lipid profiles, in a sample of 91 Korean boys aged 13–14 years who participated in a general health check-up. Results: The mean age of the boys was 13.8±0.3 years; 72 boys were normal weight and 19 were overweight/obese. The Pearson correlation coefficients revealed a significant correlation between MMP-8 and aspartate aminotransferase (r=0.217, P =0.039) and alanine aminotransferase (r=0.250, P =0.017) and between TIMP-1 and aspartate aminotransferase (r=0.267, P =0.011). In a multivariate linear regression analysis, serum alanine aminotransferase was positively associated with the MMP-8 level. There were no significant differences in the MMP-8, MMP-9, and TIMP-1 levels or MMP-8/TIMP-1 and MMP-9/TIMP-1 ratios between control and overweight/obese subjects. Conclusion: We found a significant association between the MMP-8 level and alanine aminotransferase in the apparently healthy adolescent boys. These findings indicate that there may be a pathophysiological mechanism underlying the relationship between MMP-8 and liver enzymes in young adolescents.",
author = "Shin, {Youn Ho} and Kim, {Ki Eun} and Yongjae Lee and Nam, {Jae Hwan} and Hong, {Young Mi} and Shin, {Hye Jung}",
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Associations of matrix metalloproteinase (MMP)-8; MMP-9; and their inhibitor, tissue inhibitor of metalloproteinase-1, with obesity-related biomarkers in apparently healthy adolescent boys. / Shin, Youn Ho; Kim, Ki Eun; Lee, Yongjae; Nam, Jae Hwan; Hong, Young Mi; Shin, Hye Jung.

In: Korean Journal of Pediatrics, Vol. 57, No. 12, 15.12.2014, p. 526-532.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Associations of matrix metalloproteinase (MMP)-8; MMP-9; and their inhibitor, tissue inhibitor of metalloproteinase-1, with obesity-related biomarkers in apparently healthy adolescent boys

AU - Shin, Youn Ho

AU - Kim, Ki Eun

AU - Lee, Yongjae

AU - Nam, Jae Hwan

AU - Hong, Young Mi

AU - Shin, Hye Jung

PY - 2014/12/15

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N2 - Purpose: Matrix metalloproteinases (MMPs) have been implicated in atherosclerosis, and therefore, are considered risk factors for metabolic dysfunction in adults. However, there is little data regarding circulating levels of MMPs and tissue inhibitors of MMPs (TIMPs) in the general adolescent population with regard to obesity-related biomarkers. In the present study, we determined the associations of MMP-8, MMP-9, and TIMP-1 levels and MMP-8/TIMP-1 and MMP-9/TIMP-1 ratios with obesity-related biomarkers in apparently healthy adolescent boys. Methods: We measured MMP and TIMP concentrations in plasma samples using the enzyme-linked immunosorbent assay and analyzed their associations with obesity-related biomarkers, such as liver enzymes and lipid profiles, in a sample of 91 Korean boys aged 13–14 years who participated in a general health check-up. Results: The mean age of the boys was 13.8±0.3 years; 72 boys were normal weight and 19 were overweight/obese. The Pearson correlation coefficients revealed a significant correlation between MMP-8 and aspartate aminotransferase (r=0.217, P =0.039) and alanine aminotransferase (r=0.250, P =0.017) and between TIMP-1 and aspartate aminotransferase (r=0.267, P =0.011). In a multivariate linear regression analysis, serum alanine aminotransferase was positively associated with the MMP-8 level. There were no significant differences in the MMP-8, MMP-9, and TIMP-1 levels or MMP-8/TIMP-1 and MMP-9/TIMP-1 ratios between control and overweight/obese subjects. Conclusion: We found a significant association between the MMP-8 level and alanine aminotransferase in the apparently healthy adolescent boys. These findings indicate that there may be a pathophysiological mechanism underlying the relationship between MMP-8 and liver enzymes in young adolescents.

AB - Purpose: Matrix metalloproteinases (MMPs) have been implicated in atherosclerosis, and therefore, are considered risk factors for metabolic dysfunction in adults. However, there is little data regarding circulating levels of MMPs and tissue inhibitors of MMPs (TIMPs) in the general adolescent population with regard to obesity-related biomarkers. In the present study, we determined the associations of MMP-8, MMP-9, and TIMP-1 levels and MMP-8/TIMP-1 and MMP-9/TIMP-1 ratios with obesity-related biomarkers in apparently healthy adolescent boys. Methods: We measured MMP and TIMP concentrations in plasma samples using the enzyme-linked immunosorbent assay and analyzed their associations with obesity-related biomarkers, such as liver enzymes and lipid profiles, in a sample of 91 Korean boys aged 13–14 years who participated in a general health check-up. Results: The mean age of the boys was 13.8±0.3 years; 72 boys were normal weight and 19 were overweight/obese. The Pearson correlation coefficients revealed a significant correlation between MMP-8 and aspartate aminotransferase (r=0.217, P =0.039) and alanine aminotransferase (r=0.250, P =0.017) and between TIMP-1 and aspartate aminotransferase (r=0.267, P =0.011). In a multivariate linear regression analysis, serum alanine aminotransferase was positively associated with the MMP-8 level. There were no significant differences in the MMP-8, MMP-9, and TIMP-1 levels or MMP-8/TIMP-1 and MMP-9/TIMP-1 ratios between control and overweight/obese subjects. Conclusion: We found a significant association between the MMP-8 level and alanine aminotransferase in the apparently healthy adolescent boys. These findings indicate that there may be a pathophysiological mechanism underlying the relationship between MMP-8 and liver enzymes in young adolescents.

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