Astaxanthin modulation of signaling pathways that regulate autophagy

Suhn Hyung Kim, Hyeyoung Kim

Research output: Contribution to journalReview article

Abstract

Autophagy is a lysosomal pathway that degrades and recycles unused or dysfunctional cell components as well as toxic cytosolic materials. Basal autophagy favors cell survival. However, the aberrant regulation of autophagy can promote pathological conditions. The autophagy pathway is regulated by several cell-stress and cell-survival signaling pathways that can be targeted for the purpose of disease control. In experimental models of disease, the carotenoid astaxanthin has been shown to modulate autophagy by regulating signaling pathways, including the AMP-activated protein kinase (AMPK), cellular homolog of murine thymoma virus akt8 oncogene (Akt), and mitogen-activated protein kinase (MAPK), such as c-Jun N-terminal kinase (JNK) and p38. Astaxanthin is a promising therapeutic agent for the treatment of a wide variety of diseases by regulating autophagy.

Original languageEnglish
Article number546
JournalMarine Drugs
Volume17
Issue number10
DOIs
Publication statusPublished - 2019 Sep 23

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Autophagy
Cell Survival
AMP-Activated Protein Kinases
Thymoma
JNK Mitogen-Activated Protein Kinases
Poisons
Cellular Structures
Carotenoids
Mitogen-Activated Protein Kinases
Oncogenes
astaxanthine
Theoretical Models
Viruses

All Science Journal Classification (ASJC) codes

  • Drug Discovery

Cite this

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title = "Astaxanthin modulation of signaling pathways that regulate autophagy",
abstract = "Autophagy is a lysosomal pathway that degrades and recycles unused or dysfunctional cell components as well as toxic cytosolic materials. Basal autophagy favors cell survival. However, the aberrant regulation of autophagy can promote pathological conditions. The autophagy pathway is regulated by several cell-stress and cell-survival signaling pathways that can be targeted for the purpose of disease control. In experimental models of disease, the carotenoid astaxanthin has been shown to modulate autophagy by regulating signaling pathways, including the AMP-activated protein kinase (AMPK), cellular homolog of murine thymoma virus akt8 oncogene (Akt), and mitogen-activated protein kinase (MAPK), such as c-Jun N-terminal kinase (JNK) and p38. Astaxanthin is a promising therapeutic agent for the treatment of a wide variety of diseases by regulating autophagy.",
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Astaxanthin modulation of signaling pathways that regulate autophagy. / Kim, Suhn Hyung; Kim, Hyeyoung.

In: Marine Drugs, Vol. 17, No. 10, 546, 23.09.2019.

Research output: Contribution to journalReview article

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AB - Autophagy is a lysosomal pathway that degrades and recycles unused or dysfunctional cell components as well as toxic cytosolic materials. Basal autophagy favors cell survival. However, the aberrant regulation of autophagy can promote pathological conditions. The autophagy pathway is regulated by several cell-stress and cell-survival signaling pathways that can be targeted for the purpose of disease control. In experimental models of disease, the carotenoid astaxanthin has been shown to modulate autophagy by regulating signaling pathways, including the AMP-activated protein kinase (AMPK), cellular homolog of murine thymoma virus akt8 oncogene (Akt), and mitogen-activated protein kinase (MAPK), such as c-Jun N-terminal kinase (JNK) and p38. Astaxanthin is a promising therapeutic agent for the treatment of a wide variety of diseases by regulating autophagy.

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