Asymmetric split-ring resonator-based biosensor for detection of label-free stress biomarkers

Hee Jo Lee, Jung Hyun Lee, Suji Choi, Ik Soon Jang, Jong Soon Choi, Hyo Il Jung

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39 Citations (Scopus)

Abstract

In this paper, an asymmetric split-ring resonator, metamaterial element, is presented as a biosensing transducer for detection of highly sensitive and label-free stress biomarkers. In particular, the two biomarkers, cortisol and α-amylase, are used for evaluating the sensitivity of the proposed biosensor. In case of cortisol detection, the competitive reaction between cortisol-bovine serum albumin and free cortisol is employed, while alpha-amylase is directly detected by its antigen-antibody reaction. From the experimental results, we find that the limit of detection and sensitivity of the proposed sensing device are about 1 ng/ml and 1.155 MHz/ng ml-1, respectively.

Original languageEnglish
Article number053702
JournalApplied Physics Letters
Volume103
Issue number5
DOIs
Publication statusPublished - 2013 Jul 29

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All Science Journal Classification (ASJC) codes

  • Physics and Astronomy (miscellaneous)

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