Asymmetric total synthesis of (-)-galanthamine via intramolecular heck reaction of conjugated diene

Juhee Choi, Hyunseok Kim, Sangyun Park, Jinsung Tae

Research output: Contribution to journalArticle

27 Citations (Scopus)

Abstract

Asymmetric total synthesis of (-)-galanthamine was accomplished starting from an epoxide. Intramolecular Heck reaction of a conjugated diene system was employed to construct the key quaternary carbon center. The cyclohexene-1,3-diol unit of (-)-galanthamine is derived from an optically active epoxy alkenol.

Original languageEnglish
Article numberST-2012-U1008-L
Pages (from-to)379-382
Number of pages4
JournalSynlett
Volume24
Issue number3
DOIs
Publication statusPublished - 2013 Jan 17

All Science Journal Classification (ASJC) codes

  • Organic Chemistry

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