ATG5 expression induced by MDMA (ecstasy), interferes with neuronal differentiation of neuroblastoma cells

Myounghee Chae, Gyu Seek Rhee, Ik Soon Jang, Kwangsoo Kim, Ji Hae Lee, Seung Yeul Lee, Minjung Kim, Junyoung Yang, Junsoo Park, Seung Hoon Lee

Research output: Contribution to journalArticlepeer-review

11 Citations (Scopus)

Abstract

The amphetamine derivative 3, 4-methylenedioxymethamphetamine (MDMA) has become a popular recreational drug, and has also been shown to cause serotonergic neurotoxicity. This report shows that MDMA impairs brain development in a whole mouse embryo culture. The results of quantitative real-time PCR analysis showed that autophagy-related protein 5 (Atg5) expression is elevated in mouse embryo and neuroblastoma cells after MDMA treatment. This elevated Atg5 expression interferes with the neuronal differentiation of neuroblastoma cells such as SH-SY5Y and PC12 cells. Thus, our results suggest that the use of MDMA during pregnancy may impair neuronal development via an induction of Atg5 expression.

Original languageEnglish
Pages (from-to)571-575
Number of pages5
JournalMolecules and cells
Volume27
Issue number5
DOIs
Publication statusPublished - 2009

Bibliographical note

Funding Information:
This research was supported by a grant (07142KFDA553) from Korea Food and Drug Administration in 2007 and partly by a Korea Basic Science Institute grant (KBSI-GJ-D28026 and K-MeP).

All Science Journal Classification (ASJC) codes

  • Molecular Biology
  • Cell Biology

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