Atherosclerosis in rheumatoid arthritis

Morphologic evidence obtained by carotid ultrasound

YongBeom Park, Chul Woo Ahn, Hyon K. Choi, Seung Hoon Lee, Byung Hyun In, Hyun Chul Lee, Chung Mo Nam, Soo Kon Lee

Research output: Contribution to journalArticle

223 Citations (Scopus)

Abstract

Objective. Recent studies have suggested increased cardiovascular disease among patients with rheumatoid arthritis (RA). We undertook this study to obtain morphologic evidence of subclinical atherosclerosis in RA patients. Methods. We used high-resolution B-mode ultrasound to compare carotid artery intima-media wall thickness (IMT) between 53 postmenopausal women with RA and 53 controls matched by age, sex, and menopause status. No subject in either group had a history of atherosclerosis or its complications. We investigated the association between IMT and relevant clinical and therapeutic variables, including the impact of low-dose corticosteroid therapy (≤10 mg/day prednisolone). Results. The mean ± SD IMT of the left and right common carotid arteries in RA patients was significantly greater than that in controls (0.77 ± 0.09 mm versus 0.68 ± 0.14 mm; P < 0.001). Early RA (duration ≤1 year) was associated with lesser IMT than was RA of longer duration (0.72 ± 0.03 mm versus 0.78 ± 0.01 mm; P < 0.04). Prednisolone use was not associated with increased IMT (0.78 ± 0.02 mm in nonusers versus 0.76 ± 0.01 mm in users; P = 0.38). Conclusion. Our data indicate that RA patients have an ultrasonic marker of early atherosclerosis consistent with an increased risk for atherosclerosis.

Original languageEnglish
Pages (from-to)1714-1719
Number of pages6
JournalArthritis and Rheumatism
Volume46
Issue number7
DOIs
Publication statusPublished - 2002 Jul 25

Fingerprint

Rheumatoid Arthritis
Atherosclerosis
Prednisolone
Common Carotid Artery
Menopause
Carotid Arteries
Ultrasonics
Adrenal Cortex Hormones
Cardiovascular Diseases
Therapeutics

All Science Journal Classification (ASJC) codes

  • Immunology and Allergy
  • Rheumatology
  • Immunology
  • Pharmacology (medical)

Cite this

Park, Y., Ahn, C. W., Choi, H. K., Lee, S. H., In, B. H., Lee, H. C., ... Lee, S. K. (2002). Atherosclerosis in rheumatoid arthritis: Morphologic evidence obtained by carotid ultrasound. Arthritis and Rheumatism, 46(7), 1714-1719. https://doi.org/10.1002/art.10359
Park, YongBeom ; Ahn, Chul Woo ; Choi, Hyon K. ; Lee, Seung Hoon ; In, Byung Hyun ; Lee, Hyun Chul ; Nam, Chung Mo ; Lee, Soo Kon. / Atherosclerosis in rheumatoid arthritis : Morphologic evidence obtained by carotid ultrasound. In: Arthritis and Rheumatism. 2002 ; Vol. 46, No. 7. pp. 1714-1719.
@article{a8dbf2faab5447d9ba6f9640a87cb56d,
title = "Atherosclerosis in rheumatoid arthritis: Morphologic evidence obtained by carotid ultrasound",
abstract = "Objective. Recent studies have suggested increased cardiovascular disease among patients with rheumatoid arthritis (RA). We undertook this study to obtain morphologic evidence of subclinical atherosclerosis in RA patients. Methods. We used high-resolution B-mode ultrasound to compare carotid artery intima-media wall thickness (IMT) between 53 postmenopausal women with RA and 53 controls matched by age, sex, and menopause status. No subject in either group had a history of atherosclerosis or its complications. We investigated the association between IMT and relevant clinical and therapeutic variables, including the impact of low-dose corticosteroid therapy (≤10 mg/day prednisolone). Results. The mean ± SD IMT of the left and right common carotid arteries in RA patients was significantly greater than that in controls (0.77 ± 0.09 mm versus 0.68 ± 0.14 mm; P < 0.001). Early RA (duration ≤1 year) was associated with lesser IMT than was RA of longer duration (0.72 ± 0.03 mm versus 0.78 ± 0.01 mm; P < 0.04). Prednisolone use was not associated with increased IMT (0.78 ± 0.02 mm in nonusers versus 0.76 ± 0.01 mm in users; P = 0.38). Conclusion. Our data indicate that RA patients have an ultrasonic marker of early atherosclerosis consistent with an increased risk for atherosclerosis.",
author = "YongBeom Park and Ahn, {Chul Woo} and Choi, {Hyon K.} and Lee, {Seung Hoon} and In, {Byung Hyun} and Lee, {Hyun Chul} and Nam, {Chung Mo} and Lee, {Soo Kon}",
year = "2002",
month = "7",
day = "25",
doi = "10.1002/art.10359",
language = "English",
volume = "46",
pages = "1714--1719",
journal = "Arthritis and Rheumatology",
issn = "2326-5191",
publisher = "John Wiley and Sons Ltd",
number = "7",

}

Park, Y, Ahn, CW, Choi, HK, Lee, SH, In, BH, Lee, HC, Nam, CM & Lee, SK 2002, 'Atherosclerosis in rheumatoid arthritis: Morphologic evidence obtained by carotid ultrasound', Arthritis and Rheumatism, vol. 46, no. 7, pp. 1714-1719. https://doi.org/10.1002/art.10359

Atherosclerosis in rheumatoid arthritis : Morphologic evidence obtained by carotid ultrasound. / Park, YongBeom; Ahn, Chul Woo; Choi, Hyon K.; Lee, Seung Hoon; In, Byung Hyun; Lee, Hyun Chul; Nam, Chung Mo; Lee, Soo Kon.

In: Arthritis and Rheumatism, Vol. 46, No. 7, 25.07.2002, p. 1714-1719.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Atherosclerosis in rheumatoid arthritis

T2 - Morphologic evidence obtained by carotid ultrasound

AU - Park, YongBeom

AU - Ahn, Chul Woo

AU - Choi, Hyon K.

AU - Lee, Seung Hoon

AU - In, Byung Hyun

AU - Lee, Hyun Chul

AU - Nam, Chung Mo

AU - Lee, Soo Kon

PY - 2002/7/25

Y1 - 2002/7/25

N2 - Objective. Recent studies have suggested increased cardiovascular disease among patients with rheumatoid arthritis (RA). We undertook this study to obtain morphologic evidence of subclinical atherosclerosis in RA patients. Methods. We used high-resolution B-mode ultrasound to compare carotid artery intima-media wall thickness (IMT) between 53 postmenopausal women with RA and 53 controls matched by age, sex, and menopause status. No subject in either group had a history of atherosclerosis or its complications. We investigated the association between IMT and relevant clinical and therapeutic variables, including the impact of low-dose corticosteroid therapy (≤10 mg/day prednisolone). Results. The mean ± SD IMT of the left and right common carotid arteries in RA patients was significantly greater than that in controls (0.77 ± 0.09 mm versus 0.68 ± 0.14 mm; P < 0.001). Early RA (duration ≤1 year) was associated with lesser IMT than was RA of longer duration (0.72 ± 0.03 mm versus 0.78 ± 0.01 mm; P < 0.04). Prednisolone use was not associated with increased IMT (0.78 ± 0.02 mm in nonusers versus 0.76 ± 0.01 mm in users; P = 0.38). Conclusion. Our data indicate that RA patients have an ultrasonic marker of early atherosclerosis consistent with an increased risk for atherosclerosis.

AB - Objective. Recent studies have suggested increased cardiovascular disease among patients with rheumatoid arthritis (RA). We undertook this study to obtain morphologic evidence of subclinical atherosclerosis in RA patients. Methods. We used high-resolution B-mode ultrasound to compare carotid artery intima-media wall thickness (IMT) between 53 postmenopausal women with RA and 53 controls matched by age, sex, and menopause status. No subject in either group had a history of atherosclerosis or its complications. We investigated the association between IMT and relevant clinical and therapeutic variables, including the impact of low-dose corticosteroid therapy (≤10 mg/day prednisolone). Results. The mean ± SD IMT of the left and right common carotid arteries in RA patients was significantly greater than that in controls (0.77 ± 0.09 mm versus 0.68 ± 0.14 mm; P < 0.001). Early RA (duration ≤1 year) was associated with lesser IMT than was RA of longer duration (0.72 ± 0.03 mm versus 0.78 ± 0.01 mm; P < 0.04). Prednisolone use was not associated with increased IMT (0.78 ± 0.02 mm in nonusers versus 0.76 ± 0.01 mm in users; P = 0.38). Conclusion. Our data indicate that RA patients have an ultrasonic marker of early atherosclerosis consistent with an increased risk for atherosclerosis.

UR - http://www.scopus.com/inward/record.url?scp=0036062603&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0036062603&partnerID=8YFLogxK

U2 - 10.1002/art.10359

DO - 10.1002/art.10359

M3 - Article

VL - 46

SP - 1714

EP - 1719

JO - Arthritis and Rheumatology

JF - Arthritis and Rheumatology

SN - 2326-5191

IS - 7

ER -