Atypical location and clinical behavior of a subset of intracranial germ cell tumors in children younger than 3 years of age

Wan Yee Teo, Jennifer Ross, Robert J. Bollo, Wan Tew Seow, Ah Moy Tan, Seok-Gu Kang, Dong Seok Kim, Xiao Nan Li, Ching C. Lau, Carrie A. Mohila, Adekunle M. Adesina, Jack M. Su

Research output: Contribution to journalArticle

Abstract

The authors describe a series of 15 intracranial germ cell tumors (IGCTs) excluding mature teratomas; 3 cases in children younger than 3 years of age who were treated at 3 different international institutions over the course of 20 years, and 12 from a PubMed search. These tumors, with possible in utero origins, often occur in atypical locations. The clinical behavior differed significantly from these tumors' counterparts in older children. In this young age group germinoma is highly aggressive, whereas nongerminomatous germ cell tumors may be cured without radiotherapy. Ongoing genomic studies reveal insights to attain an understanding of the biology of these tumors. New treatment strategies are needed to improve outcomes for IGCTs in this age group, particularly for germinomas.

Original languageEnglish
Pages (from-to)348-355
Number of pages8
JournalJournal of Neurosurgery: Pediatrics
Volume14
Issue number4
DOIs
Publication statusPublished - 2014 Jan 1

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Germ Cell and Embryonal Neoplasms
Germinoma
Age Groups
Neoplasms
Teratoma
PubMed
Radiotherapy
Therapeutics

All Science Journal Classification (ASJC) codes

  • Surgery
  • Pediatrics, Perinatology, and Child Health
  • Clinical Neurology

Cite this

Teo, Wan Yee ; Ross, Jennifer ; Bollo, Robert J. ; Seow, Wan Tew ; Tan, Ah Moy ; Kang, Seok-Gu ; Kim, Dong Seok ; Li, Xiao Nan ; Lau, Ching C. ; Mohila, Carrie A. ; Adesina, Adekunle M. ; Su, Jack M. / Atypical location and clinical behavior of a subset of intracranial germ cell tumors in children younger than 3 years of age. In: Journal of Neurosurgery: Pediatrics. 2014 ; Vol. 14, No. 4. pp. 348-355.
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Teo, WY, Ross, J, Bollo, RJ, Seow, WT, Tan, AM, Kang, S-G, Kim, DS, Li, XN, Lau, CC, Mohila, CA, Adesina, AM & Su, JM 2014, 'Atypical location and clinical behavior of a subset of intracranial germ cell tumors in children younger than 3 years of age', Journal of Neurosurgery: Pediatrics, vol. 14, no. 4, pp. 348-355. https://doi.org/10.3171/2014.6.PEDS13651

Atypical location and clinical behavior of a subset of intracranial germ cell tumors in children younger than 3 years of age. / Teo, Wan Yee; Ross, Jennifer; Bollo, Robert J.; Seow, Wan Tew; Tan, Ah Moy; Kang, Seok-Gu; Kim, Dong Seok; Li, Xiao Nan; Lau, Ching C.; Mohila, Carrie A.; Adesina, Adekunle M.; Su, Jack M.

In: Journal of Neurosurgery: Pediatrics, Vol. 14, No. 4, 01.01.2014, p. 348-355.

Research output: Contribution to journalArticle

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