Augmentation index association with reactive hyperemia as assessed by peripheral arterial tonometry in hypertension

Woo In Yang, Sungha Park, Jong Chan Youn, Nak Hoon Son, Sang Hak Lee, seokmin kang, Yangsoo Jang

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Background Augmentation pressure has emerged as a surrogate marker for cardiovascular disease, and endothelial dysfunction has been proposed as related factor. However, the relationship between augmentation pressure and digital endothelial function has not yet been well defined. We investigated the relationship between augmentation pressure and digital reactive hyperemia (RH) in patients with hypertension using peripheral arterial tonometry (PAT), which is regarded as being representative of endothelial function. Methods One hundred hypertensive patients (64 males; mean age, 49 ± 12 years) without a history of taking antihypertensive medication were enrolled in this study. Results The mean augmentation pressure and augmentation index (AIx) normalized for a heart rate of 75 beats/min (AIx75) were 15 ± 8 mm Hg and 26 ± 11%, respectively. The mean RH-PAT index and log transformed PAT ratio were 2.24 ± 0.55 and 0.62 ± 0.30. There was an inverse relationship between the RH-PAT index and age, male sex, and body mass index. The log transformed PAT ratio also showed inverse relationship with age and male sex. The RH-PAT index and the log transformed PAT ratio showed no relationship with augmentation pressure or AIx75. In a multiple linear regression analysis, age, height, and central systolic BP demonstrated an independent association with augmentation pressure and AIx75.ConclusionIn patients with hypertension, the RH-PAT index determined using PAT was not associated with augmentation pressure or AIx75. Digital vascular function may be a less important factor for pressure augmentation in patients with hypertension.

Original languageEnglish
Pages (from-to)1234-1238
Number of pages5
JournalAmerican Journal of Hypertension
Volume24
Issue number11
DOIs
Publication statusPublished - 2011 Nov 1

Fingerprint

Hyperemia
Manometry
Hypertension
Pressure
Antihypertensive Agents
Blood Vessels
Linear Models
Body Mass Index
Cardiovascular Diseases
Biomarkers
Heart Rate
Regression Analysis

All Science Journal Classification (ASJC) codes

  • Internal Medicine

Cite this

@article{ef569f2c39234567bac35e66e359da2d,
title = "Augmentation index association with reactive hyperemia as assessed by peripheral arterial tonometry in hypertension",
abstract = "Background Augmentation pressure has emerged as a surrogate marker for cardiovascular disease, and endothelial dysfunction has been proposed as related factor. However, the relationship between augmentation pressure and digital endothelial function has not yet been well defined. We investigated the relationship between augmentation pressure and digital reactive hyperemia (RH) in patients with hypertension using peripheral arterial tonometry (PAT), which is regarded as being representative of endothelial function. Methods One hundred hypertensive patients (64 males; mean age, 49 ± 12 years) without a history of taking antihypertensive medication were enrolled in this study. Results The mean augmentation pressure and augmentation index (AIx) normalized for a heart rate of 75 beats/min (AIx75) were 15 ± 8 mm Hg and 26 ± 11{\%}, respectively. The mean RH-PAT index and log transformed PAT ratio were 2.24 ± 0.55 and 0.62 ± 0.30. There was an inverse relationship between the RH-PAT index and age, male sex, and body mass index. The log transformed PAT ratio also showed inverse relationship with age and male sex. The RH-PAT index and the log transformed PAT ratio showed no relationship with augmentation pressure or AIx75. In a multiple linear regression analysis, age, height, and central systolic BP demonstrated an independent association with augmentation pressure and AIx75.ConclusionIn patients with hypertension, the RH-PAT index determined using PAT was not associated with augmentation pressure or AIx75. Digital vascular function may be a less important factor for pressure augmentation in patients with hypertension.",
author = "Yang, {Woo In} and Sungha Park and Youn, {Jong Chan} and Son, {Nak Hoon} and Lee, {Sang Hak} and seokmin kang and Yangsoo Jang",
year = "2011",
month = "11",
day = "1",
doi = "10.1038/ajh.2011.132",
language = "English",
volume = "24",
pages = "1234--1238",
journal = "American Journal of Hypertension",
issn = "0895-7061",
publisher = "Oxford University Press",
number = "11",

}

Augmentation index association with reactive hyperemia as assessed by peripheral arterial tonometry in hypertension. / Yang, Woo In; Park, Sungha; Youn, Jong Chan; Son, Nak Hoon; Lee, Sang Hak; kang, seokmin; Jang, Yangsoo.

In: American Journal of Hypertension, Vol. 24, No. 11, 01.11.2011, p. 1234-1238.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Augmentation index association with reactive hyperemia as assessed by peripheral arterial tonometry in hypertension

AU - Yang, Woo In

AU - Park, Sungha

AU - Youn, Jong Chan

AU - Son, Nak Hoon

AU - Lee, Sang Hak

AU - kang, seokmin

AU - Jang, Yangsoo

PY - 2011/11/1

Y1 - 2011/11/1

N2 - Background Augmentation pressure has emerged as a surrogate marker for cardiovascular disease, and endothelial dysfunction has been proposed as related factor. However, the relationship between augmentation pressure and digital endothelial function has not yet been well defined. We investigated the relationship between augmentation pressure and digital reactive hyperemia (RH) in patients with hypertension using peripheral arterial tonometry (PAT), which is regarded as being representative of endothelial function. Methods One hundred hypertensive patients (64 males; mean age, 49 ± 12 years) without a history of taking antihypertensive medication were enrolled in this study. Results The mean augmentation pressure and augmentation index (AIx) normalized for a heart rate of 75 beats/min (AIx75) were 15 ± 8 mm Hg and 26 ± 11%, respectively. The mean RH-PAT index and log transformed PAT ratio were 2.24 ± 0.55 and 0.62 ± 0.30. There was an inverse relationship between the RH-PAT index and age, male sex, and body mass index. The log transformed PAT ratio also showed inverse relationship with age and male sex. The RH-PAT index and the log transformed PAT ratio showed no relationship with augmentation pressure or AIx75. In a multiple linear regression analysis, age, height, and central systolic BP demonstrated an independent association with augmentation pressure and AIx75.ConclusionIn patients with hypertension, the RH-PAT index determined using PAT was not associated with augmentation pressure or AIx75. Digital vascular function may be a less important factor for pressure augmentation in patients with hypertension.

AB - Background Augmentation pressure has emerged as a surrogate marker for cardiovascular disease, and endothelial dysfunction has been proposed as related factor. However, the relationship between augmentation pressure and digital endothelial function has not yet been well defined. We investigated the relationship between augmentation pressure and digital reactive hyperemia (RH) in patients with hypertension using peripheral arterial tonometry (PAT), which is regarded as being representative of endothelial function. Methods One hundred hypertensive patients (64 males; mean age, 49 ± 12 years) without a history of taking antihypertensive medication were enrolled in this study. Results The mean augmentation pressure and augmentation index (AIx) normalized for a heart rate of 75 beats/min (AIx75) were 15 ± 8 mm Hg and 26 ± 11%, respectively. The mean RH-PAT index and log transformed PAT ratio were 2.24 ± 0.55 and 0.62 ± 0.30. There was an inverse relationship between the RH-PAT index and age, male sex, and body mass index. The log transformed PAT ratio also showed inverse relationship with age and male sex. The RH-PAT index and the log transformed PAT ratio showed no relationship with augmentation pressure or AIx75. In a multiple linear regression analysis, age, height, and central systolic BP demonstrated an independent association with augmentation pressure and AIx75.ConclusionIn patients with hypertension, the RH-PAT index determined using PAT was not associated with augmentation pressure or AIx75. Digital vascular function may be a less important factor for pressure augmentation in patients with hypertension.

UR - http://www.scopus.com/inward/record.url?scp=80054886557&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=80054886557&partnerID=8YFLogxK

U2 - 10.1038/ajh.2011.132

DO - 10.1038/ajh.2011.132

M3 - Article

C2 - 21901014

AN - SCOPUS:80054886557

VL - 24

SP - 1234

EP - 1238

JO - American Journal of Hypertension

JF - American Journal of Hypertension

SN - 0895-7061

IS - 11

ER -