Augmented re-endothelialization and anti-inflammation of coronary drug-eluting stent by abluminal coating with magnesium hydroxide

Da Won Jeong, Wooram Park, Tarek M. Bedair, Eun Young Kang, Ik Hwan Kim, Dae Sung Park, Doo Sun Sim, Young Joon Hong, Won Gun Koh, Myung Ho Jeong, Dong Keun Han

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Drug-eluting stents (DESs) have been widely used as a treatment approach for coronary artery diseases. Generally, conventional DESs were fully covered with drugs and biodegradable polymers on both abluminal and luminal layers (i.e., conformal coating). However, uncontrolled drug release from the luminal drug-coating layer of the stent is known to inhibit re-endothelialization. Furthermore, the acidification of the surrounding tissue by the decomposed coating polymer causes inflammation, resulting in restenosis and late thrombosis. To overcome these limitations, here we demonstrated a functional DES coated with poly(lactic-co-glycolic acid) (PLGA), sirolimus (SRL), and magnesium hydroxide (Mg(OH)2, MH) precisely only on the abluminal layer. The acidic neutralization effect of MH was elucidated by measuring the pH change of the fabricated film in PBS solution. In an in vitro cell study, the stent coated with MH exhibited higher compatibility with human coronary artery endothelial cells (ECs) and a lower inflammation score as compared to the control stent. Finally, in an in vivo large porcine model, the abluminal coated DES with SRL and MH showed excellent re-endothelialization and anti-inflammatory and anti-thrombotic effects. In conclusion, it is believed that this approach has great potential for the development of functional DES for the treatment of cardiovascular diseases.

Original languageEnglish
Pages (from-to)2499-2510
Number of pages12
JournalBiomaterials Science
Volume7
Issue number6
DOIs
Publication statusPublished - 2019 Jun

Fingerprint

Magnesium Hydroxide
Stents
Magnesium
Coatings
Pharmaceutical Preparations
Sirolimus
Biodegradable polymers
Acidification
Endothelial cells
Polymers
Anti-Inflammatory Agents
Tissue

All Science Journal Classification (ASJC) codes

  • Biomedical Engineering
  • Materials Science(all)

Cite this

Jeong, Da Won ; Park, Wooram ; Bedair, Tarek M. ; Kang, Eun Young ; Kim, Ik Hwan ; Park, Dae Sung ; Sim, Doo Sun ; Hong, Young Joon ; Koh, Won Gun ; Jeong, Myung Ho ; Han, Dong Keun. / Augmented re-endothelialization and anti-inflammation of coronary drug-eluting stent by abluminal coating with magnesium hydroxide. In: Biomaterials Science. 2019 ; Vol. 7, No. 6. pp. 2499-2510.
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abstract = "Drug-eluting stents (DESs) have been widely used as a treatment approach for coronary artery diseases. Generally, conventional DESs were fully covered with drugs and biodegradable polymers on both abluminal and luminal layers (i.e., conformal coating). However, uncontrolled drug release from the luminal drug-coating layer of the stent is known to inhibit re-endothelialization. Furthermore, the acidification of the surrounding tissue by the decomposed coating polymer causes inflammation, resulting in restenosis and late thrombosis. To overcome these limitations, here we demonstrated a functional DES coated with poly(lactic-co-glycolic acid) (PLGA), sirolimus (SRL), and magnesium hydroxide (Mg(OH)2, MH) precisely only on the abluminal layer. The acidic neutralization effect of MH was elucidated by measuring the pH change of the fabricated film in PBS solution. In an in vitro cell study, the stent coated with MH exhibited higher compatibility with human coronary artery endothelial cells (ECs) and a lower inflammation score as compared to the control stent. Finally, in an in vivo large porcine model, the abluminal coated DES with SRL and MH showed excellent re-endothelialization and anti-inflammatory and anti-thrombotic effects. In conclusion, it is believed that this approach has great potential for the development of functional DES for the treatment of cardiovascular diseases.",
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Jeong, DW, Park, W, Bedair, TM, Kang, EY, Kim, IH, Park, DS, Sim, DS, Hong, YJ, Koh, WG, Jeong, MH & Han, DK 2019, 'Augmented re-endothelialization and anti-inflammation of coronary drug-eluting stent by abluminal coating with magnesium hydroxide', Biomaterials Science, vol. 7, no. 6, pp. 2499-2510. https://doi.org/10.1039/c8bm01696h

Augmented re-endothelialization and anti-inflammation of coronary drug-eluting stent by abluminal coating with magnesium hydroxide. / Jeong, Da Won; Park, Wooram; Bedair, Tarek M.; Kang, Eun Young; Kim, Ik Hwan; Park, Dae Sung; Sim, Doo Sun; Hong, Young Joon; Koh, Won Gun; Jeong, Myung Ho; Han, Dong Keun.

In: Biomaterials Science, Vol. 7, No. 6, 06.2019, p. 2499-2510.

Research output: Contribution to journalArticle

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T1 - Augmented re-endothelialization and anti-inflammation of coronary drug-eluting stent by abluminal coating with magnesium hydroxide

AU - Jeong, Da Won

AU - Park, Wooram

AU - Bedair, Tarek M.

AU - Kang, Eun Young

AU - Kim, Ik Hwan

AU - Park, Dae Sung

AU - Sim, Doo Sun

AU - Hong, Young Joon

AU - Koh, Won Gun

AU - Jeong, Myung Ho

AU - Han, Dong Keun

PY - 2019/6

Y1 - 2019/6

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