Autologous bone marrow infusion activates the progenitor cell compartment in patients with advanced liver cirrhosis

Ja Kyung Kim, Young Nyun Park, Jin Seok Kim, Mi Suk Park, Yong Han Paik, Jae Yeon Seok, Yong Eun Chung, Hyun Ok Kim, Kyung Sik Kim, Sang Hoon Ahn, Do Young Kim, Myeong Jin Kim, Kwan Sik Lee, Chae Yoon Chon, Soo Jeong Kim, Shuji Terai, Isao Sakaida, Kwang Hyub Han

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Abstract

Several clinical trials of bone marrow cell infusion in patients with liver cirrhosis (LC) have shown clinical improvement, despite conflicting results from animal models. We investigated serial pathological features and the clinical impact after autologous bone marrow infusion (ABMI) in patients with advanced LC. Ten patients with advanced LC due to chronic hepatitis B virus infection underwent ABMI. Serological tests, MRI, and liver biopsies were performed, and quality of life was assessed by a questionnaire. Median serum albumin and hemoglobin levels increased significantly after ABMI. All patients showed an improvement in quality of life, with no serious adverse events. Liver volume, measured by MRI, increased in 80% of the patients, and ascites decreased after ABMI. Child-Pugh scores were also significantly improved at 6 months after ABMI. In the serially biopsied livers, a gradually increasing activation of the hepatic progenitor cell (HPC) compartment, including HPC activation (ductular reaction) and HPC differentiation (intermediate hepatocyte), reached a peak after 3 months, with continued proliferation of hepatocytes, and returned to baseline levels after 6 months. There was no significant change in grade or stage of liver fibrosis or stellate cell activation after ABMI. ABMI is suggested to improve liver function and to activate the progenitor cell compartment. Although clinical improvement was sustained for more than 6 months, histological changes in the liver returned to baseline 6 months after ABMI. Further comparative studies are warranted.

Original languageEnglish
Pages (from-to)1237-1246
Number of pages10
JournalCell transplantation
Volume19
Issue number10
DOIs
Publication statusPublished - 2010 Dec 1

All Science Journal Classification (ASJC) codes

  • Biomedical Engineering
  • Cell Biology
  • Transplantation

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    Kim, J. K., Park, Y. N., Kim, J. S., Park, M. S., Paik, Y. H., Seok, J. Y., Chung, Y. E., Kim, H. O., Kim, K. S., Ahn, S. H., Kim, D. Y., Kim, M. J., Lee, K. S., Chon, C. Y., Kim, S. J., Terai, S., Sakaida, I., & Han, K. H. (2010). Autologous bone marrow infusion activates the progenitor cell compartment in patients with advanced liver cirrhosis. Cell transplantation, 19(10), 1237-1246. https://doi.org/10.3727/096368910X506863