Autologous fibrin glue in peripheral nerve regeneration in vivo

Byung Ho Choi, Sang Gyun Han, Sung Hoon Kim, Shi Jiang Zhu, Jin Young Huh, Jae Hyung Jung, Seoung Ho Lee, Byung Yong Kim

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17 Citations (Scopus)

Abstract

The activity of several growth factors on peripheral nerve regeneration is reported. Autologous fibrin glue contains a large number of platelets, which release significant quantities of growth factors. In order to understand the role of autologous fibrin glue in peripheral nerve regeneration, a 15-mm rabbit peroneal nerve defect was repaired using a vein graft filled with autologous fibrin glue. Axonal regeneration was examined using histological and electrophysiological methods. The extent of axonal regeneration was superior when treated with autologous fibrin glue. Our data suggest that fibrin nets formed by fibrinogen, in combination with growth factors present in autologous fibrin glue, might effectively promote peripheral nerve regeneration in nerve defects.

Original languageEnglish
Pages (from-to)495-499
Number of pages5
JournalMicrosurgery
Volume25
Issue number6
DOIs
Publication statusPublished - 2005 Oct 21

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All Science Journal Classification (ASJC) codes

  • Surgery

Cite this

Choi, B. H., Han, S. G., Kim, S. H., Zhu, S. J., Huh, J. Y., Jung, J. H., Lee, S. H., & Kim, B. Y. (2005). Autologous fibrin glue in peripheral nerve regeneration in vivo. Microsurgery, 25(6), 495-499. https://doi.org/10.1002/micr.20154