Automated preparation of 188Re-labeled radiopharmaceuticals for endovascular radiation therapy

Seung Jun Oh, Dae Hyuk Moon, Won Woo Lee, Seong Wook Park, Myeong Ki Hong, Seung Jung Park, Dong Ik Shin, Hee Kyung Lee

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Abstract

We have developed an automated system for the preparation of highly concentrated 188Re-perrhenate, diethylenetriamine pentaacetic acid (DTPA) and mercaptoacetyltriglycine (MAG3). The three procedural steps include concentration of 188Re-perrhanerate, chelation and purification and sterilization. The steps are operated by a small micro-controller. The eluted 188Re-perrhenate of 15GBq/18ml from 37GBq 188W/188Re-generator was concentrated to 1.2ml in 10±0.5min with a recovery yield of 95±1.5%. We obtained the highest radiochemical yield of 95.4±2.8% and 98.5±1.2% for 188Re-DTPA and MAG3 at the oil bath temperatures of 95-97°C and 93-97°C, respectively.

Original languageEnglish
Pages (from-to)225-230
Number of pages6
JournalApplied Radiation and Isotopes
Volume59
Issue number4
DOIs
Publication statusPublished - 2003 Oct 1

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All Science Journal Classification (ASJC) codes

  • Radiation

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