Automation of the synthesis of highly concentrated 188Re-MAG3 for intracoronary radiation therapy

Seung Jun Oh, Dae Hyuk Moon, Hyun Joon Ha, Seong Wook Park, Myeong Ki Hong, Seung Jung Park, Tae Hyun Choi, Sang Moo Lim, Chang Woon Choi, F. F. Knapp, Hee Kyung Lee

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18 Citations (Scopus)

Abstract

We have developed an efficient method and an automated synthetic system for the preparation of highly concentrated 188Re-MAG3. Routine production of 188Re-MAG3 for use in intracoronary radiation therapy was performed by compressed air driven semi-automated shielded system. 188Re-MAG3 was prepared with a commercial kit and reducing agents, purified and concentrated by C18 Sep-Pak cartridges to desired radioactivity and volume. Using this automated system, reproducible radiolabeling yields of 80-85% were obtained.

Original languageEnglish
Pages (from-to)419-427
Number of pages9
JournalApplied Radiation and Isotopes
Volume54
Issue number3
DOIs
Publication statusPublished - 2001 Feb 19

All Science Journal Classification (ASJC) codes

  • Radiation

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    Oh, S. J., Moon, D. H., Ha, H. J., Park, S. W., Hong, M. K., Park, S. J., Choi, T. H., Lim, S. M., Choi, C. W., Knapp, F. F., & Lee, H. K. (2001). Automation of the synthesis of highly concentrated 188Re-MAG3 for intracoronary radiation therapy. Applied Radiation and Isotopes, 54(3), 419-427. https://doi.org/10.1016/S0969-8043(00)00279-7