Autonomic nerve activity and the short-term variability of the T peak-Tend interval in dogs with pacing-induced heart failure

Gianfranco Piccirillo, Damiano Magrì, Maria A. Pappadà, Antonello Maruotti, Masahiro Ogawa, Seongwook Han, Boyoung Joung, Pietro Rossi, Bich Lien Nguyen, Shien Fong Lin, Peng Sheng Chen

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Abstract

BACKGROUND: In congestive heart failure (CHF), autonomic nervous system (ANS) activity is known to modulate arrhythmic risk through its effects on myocardial repolarization. An increased interval between the peak and the end of the T wave (Tpeak-Tend) has been reported to increase the incidence of sudden cardiac death. However, the ANS influence on the T peak-Tend interval remains unclear. OBJECTIVE: We directly measured ANS nerve activity in ambulatory dogs with pacing-induced CHF to test the hypothesis that ANS activity modulates the Tpeak-Tend variability index (Tpeak-TendVI), the short-term variability of the Tpeak-Tend interval obtained on 30 beats (Tpeak-TendSTV30), and the short-term variability of the Tpeak-Tend interval obtained on 5-minute ECG recording (Tpeak-TendSTVT). METHODS: By using data previously recorded in 6 ambulatory dogs before and after pacing-induced CHF, we assessed ANS activity recorded with an implanted radiotransmitter that monitored integrated left stellate ganglion nervous activity (iSGNA), integrated vagus nerve activity (iVNA), and electrocardiogram (ECG). We selected for analysis 36 segments recorded at baseline and 36 after pacing-induced CHF with similar iSGNA. RESULTS: During CHF, T peak-TendSTV30 (P<.001) and T peak-TendSTVT (P<.05) were significantly higher than those at baseline. The multiple linear mixed regression analysis disclosed a significant positive correlation between iSGNA and T peak-TendSTVT (baseline: β 2.92, P<.001; CHF: β 1.13, P<.001) and a significant negative correlation between iVNA and Tpeak-TendSTVT (baseline: β-6.74, P<.001; CHF: β-1.42, P<.001). CONCLUSIONS: In a canine model of pacing-induced CHF, iSGNA correlates positively while iVNA correlates negatively with Tpeak-TendSTVT. These findings suggest that SGNA increases while VNA decreases the dispersion of ventricular repolarization in ambulatory dogs with CHF.

Original languageEnglish
Pages (from-to)2044-2050
Number of pages7
JournalHeart Rhythm
Volume9
Issue number12
DOIs
Publication statusPublished - 2012 Dec 1

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Autonomic Pathways
Heart Failure
Dogs
Autonomic Nervous System
Stellate Ganglion
Vagus Nerve
Electrocardiography
Sudden Cardiac Death
Canidae
Linear Models
Regression Analysis

All Science Journal Classification (ASJC) codes

  • Cardiology and Cardiovascular Medicine
  • Physiology (medical)

Cite this

Piccirillo, G., Magrì, D., Pappadà, M. A., Maruotti, A., Ogawa, M., Han, S., ... Chen, P. S. (2012). Autonomic nerve activity and the short-term variability of the T peak-Tend interval in dogs with pacing-induced heart failure. Heart Rhythm, 9(12), 2044-2050. https://doi.org/10.1016/j.hrthm.2012.08.030
Piccirillo, Gianfranco ; Magrì, Damiano ; Pappadà, Maria A. ; Maruotti, Antonello ; Ogawa, Masahiro ; Han, Seongwook ; Joung, Boyoung ; Rossi, Pietro ; Nguyen, Bich Lien ; Lin, Shien Fong ; Chen, Peng Sheng. / Autonomic nerve activity and the short-term variability of the T peak-Tend interval in dogs with pacing-induced heart failure. In: Heart Rhythm. 2012 ; Vol. 9, No. 12. pp. 2044-2050.
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abstract = "BACKGROUND: In congestive heart failure (CHF), autonomic nervous system (ANS) activity is known to modulate arrhythmic risk through its effects on myocardial repolarization. An increased interval between the peak and the end of the T wave (Tpeak-Tend) has been reported to increase the incidence of sudden cardiac death. However, the ANS influence on the T peak-Tend interval remains unclear. OBJECTIVE: We directly measured ANS nerve activity in ambulatory dogs with pacing-induced CHF to test the hypothesis that ANS activity modulates the Tpeak-Tend variability index (Tpeak-TendVI), the short-term variability of the Tpeak-Tend interval obtained on 30 beats (Tpeak-TendSTV30), and the short-term variability of the Tpeak-Tend interval obtained on 5-minute ECG recording (Tpeak-TendSTVT). METHODS: By using data previously recorded in 6 ambulatory dogs before and after pacing-induced CHF, we assessed ANS activity recorded with an implanted radiotransmitter that monitored integrated left stellate ganglion nervous activity (iSGNA), integrated vagus nerve activity (iVNA), and electrocardiogram (ECG). We selected for analysis 36 segments recorded at baseline and 36 after pacing-induced CHF with similar iSGNA. RESULTS: During CHF, T peak-TendSTV30 (P<.001) and T peak-TendSTVT (P<.05) were significantly higher than those at baseline. The multiple linear mixed regression analysis disclosed a significant positive correlation between iSGNA and T peak-TendSTVT (baseline: β 2.92, P<.001; CHF: β 1.13, P<.001) and a significant negative correlation between iVNA and Tpeak-TendSTVT (baseline: β-6.74, P<.001; CHF: β-1.42, P<.001). CONCLUSIONS: In a canine model of pacing-induced CHF, iSGNA correlates positively while iVNA correlates negatively with Tpeak-TendSTVT. These findings suggest that SGNA increases while VNA decreases the dispersion of ventricular repolarization in ambulatory dogs with CHF.",
author = "Gianfranco Piccirillo and Damiano Magr{\`i} and Pappad{\`a}, {Maria A.} and Antonello Maruotti and Masahiro Ogawa and Seongwook Han and Boyoung Joung and Pietro Rossi and Nguyen, {Bich Lien} and Lin, {Shien Fong} and Chen, {Peng Sheng}",
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Piccirillo, G, Magrì, D, Pappadà, MA, Maruotti, A, Ogawa, M, Han, S, Joung, B, Rossi, P, Nguyen, BL, Lin, SF & Chen, PS 2012, 'Autonomic nerve activity and the short-term variability of the T peak-Tend interval in dogs with pacing-induced heart failure', Heart Rhythm, vol. 9, no. 12, pp. 2044-2050. https://doi.org/10.1016/j.hrthm.2012.08.030

Autonomic nerve activity and the short-term variability of the T peak-Tend interval in dogs with pacing-induced heart failure. / Piccirillo, Gianfranco; Magrì, Damiano; Pappadà, Maria A.; Maruotti, Antonello; Ogawa, Masahiro; Han, Seongwook; Joung, Boyoung; Rossi, Pietro; Nguyen, Bich Lien; Lin, Shien Fong; Chen, Peng Sheng.

In: Heart Rhythm, Vol. 9, No. 12, 01.12.2012, p. 2044-2050.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Autonomic nerve activity and the short-term variability of the T peak-Tend interval in dogs with pacing-induced heart failure

AU - Piccirillo, Gianfranco

AU - Magrì, Damiano

AU - Pappadà, Maria A.

AU - Maruotti, Antonello

AU - Ogawa, Masahiro

AU - Han, Seongwook

AU - Joung, Boyoung

AU - Rossi, Pietro

AU - Nguyen, Bich Lien

AU - Lin, Shien Fong

AU - Chen, Peng Sheng

PY - 2012/12/1

Y1 - 2012/12/1

N2 - BACKGROUND: In congestive heart failure (CHF), autonomic nervous system (ANS) activity is known to modulate arrhythmic risk through its effects on myocardial repolarization. An increased interval between the peak and the end of the T wave (Tpeak-Tend) has been reported to increase the incidence of sudden cardiac death. However, the ANS influence on the T peak-Tend interval remains unclear. OBJECTIVE: We directly measured ANS nerve activity in ambulatory dogs with pacing-induced CHF to test the hypothesis that ANS activity modulates the Tpeak-Tend variability index (Tpeak-TendVI), the short-term variability of the Tpeak-Tend interval obtained on 30 beats (Tpeak-TendSTV30), and the short-term variability of the Tpeak-Tend interval obtained on 5-minute ECG recording (Tpeak-TendSTVT). METHODS: By using data previously recorded in 6 ambulatory dogs before and after pacing-induced CHF, we assessed ANS activity recorded with an implanted radiotransmitter that monitored integrated left stellate ganglion nervous activity (iSGNA), integrated vagus nerve activity (iVNA), and electrocardiogram (ECG). We selected for analysis 36 segments recorded at baseline and 36 after pacing-induced CHF with similar iSGNA. RESULTS: During CHF, T peak-TendSTV30 (P<.001) and T peak-TendSTVT (P<.05) were significantly higher than those at baseline. The multiple linear mixed regression analysis disclosed a significant positive correlation between iSGNA and T peak-TendSTVT (baseline: β 2.92, P<.001; CHF: β 1.13, P<.001) and a significant negative correlation between iVNA and Tpeak-TendSTVT (baseline: β-6.74, P<.001; CHF: β-1.42, P<.001). CONCLUSIONS: In a canine model of pacing-induced CHF, iSGNA correlates positively while iVNA correlates negatively with Tpeak-TendSTVT. These findings suggest that SGNA increases while VNA decreases the dispersion of ventricular repolarization in ambulatory dogs with CHF.

AB - BACKGROUND: In congestive heart failure (CHF), autonomic nervous system (ANS) activity is known to modulate arrhythmic risk through its effects on myocardial repolarization. An increased interval between the peak and the end of the T wave (Tpeak-Tend) has been reported to increase the incidence of sudden cardiac death. However, the ANS influence on the T peak-Tend interval remains unclear. OBJECTIVE: We directly measured ANS nerve activity in ambulatory dogs with pacing-induced CHF to test the hypothesis that ANS activity modulates the Tpeak-Tend variability index (Tpeak-TendVI), the short-term variability of the Tpeak-Tend interval obtained on 30 beats (Tpeak-TendSTV30), and the short-term variability of the Tpeak-Tend interval obtained on 5-minute ECG recording (Tpeak-TendSTVT). METHODS: By using data previously recorded in 6 ambulatory dogs before and after pacing-induced CHF, we assessed ANS activity recorded with an implanted radiotransmitter that monitored integrated left stellate ganglion nervous activity (iSGNA), integrated vagus nerve activity (iVNA), and electrocardiogram (ECG). We selected for analysis 36 segments recorded at baseline and 36 after pacing-induced CHF with similar iSGNA. RESULTS: During CHF, T peak-TendSTV30 (P<.001) and T peak-TendSTVT (P<.05) were significantly higher than those at baseline. The multiple linear mixed regression analysis disclosed a significant positive correlation between iSGNA and T peak-TendSTVT (baseline: β 2.92, P<.001; CHF: β 1.13, P<.001) and a significant negative correlation between iVNA and Tpeak-TendSTVT (baseline: β-6.74, P<.001; CHF: β-1.42, P<.001). CONCLUSIONS: In a canine model of pacing-induced CHF, iSGNA correlates positively while iVNA correlates negatively with Tpeak-TendSTVT. These findings suggest that SGNA increases while VNA decreases the dispersion of ventricular repolarization in ambulatory dogs with CHF.

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