Abstract
Macroautophagy/autophagy is a conserved degradation system that engulfs intracytoplasmic contents, including aggregated proteins and organelles, which is crucial for cellular homeostasis. During aging, cellular factors suggested as the cause of aging have been reported to be associated with progressively compromised autophagy. Dysfunctional autophagy may contribute to age-related diseases, such as neurodegenerative disease, cancer, and metabolic syndrome, in the elderly. Therefore, restoration of impaired autophagy to normal may help to prevent age-related disease and extend lifespan and longevity. Therefore, this review aims to provide an overview of the mechanisms of autophagy underlying cellular aging and the consequent disease. Understanding the mechanisms of autophagy may provide potential information to aid therapeutic interventions in age-related diseases.
| Original language | English |
|---|---|
| Pages (from-to) | 643-657 |
| Number of pages | 15 |
| Journal | Experimental Neurobiology |
| Volume | 28 |
| Issue number | 6 |
| DOIs | |
| Publication status | Published - 2019 |
Bibliographical note
Funding Information:We are grateful for funding from the UK Dementia Research Institute (funded by the MRC, Alzheimer’s Research UK and the Alzheimer’s Society), Roger de Spoelberch Foundation, Alzheimer’s Research UK, The Tau Consortium, Cambridge Centre for Parkinson-Plus, National Institute for Health Research Cambridge Biomedical Research Centre (D.C.R.), and the Korea Health Technology R&D Project (HI14C2173) through the Korea Health Industry Development Institute, funded by the Ministry of Health & Welfare, Republic of Korea (S.Y.C., H. K., and J.E.L). The views expressed are those of the author(s) and not necessarily those of the NHS, the NIHR or the Department of Health and Social Care.
Funding Information:
We are grateful for funding from the UK Dementia Research Institute (funded by the MRC, Alzheimer's Research UK and the Alzheimer's Society), Roger de Spoelberch Foundation, Alzheimer's Research UK, The Tau Consortium, Cambridge Centre for Parkinson-Plus, National Institute for Health Research Cambridge Biomedical Research Centre (D.C.R.), and the Korea Health Technology R&D Project (HI14C2173) through the Korea Health Industry Development Institute, funded by the Ministry of Health & Welfare, Republic of Korea (S.Y.C., H. K., and J.E.L). The views expressed are those of the author(s) and not necessarily those of the NHS, the NIHR or the Department of Health and Social Care. The authors thank MID (Medical Illustration & Design), a part of the Medical Research Support Services of Yonsei University College of Medicine, for all artistic support related to this work.
Publisher Copyright:
Copyright © Experimental Neurobiology 2019.
All Science Journal Classification (ASJC) codes
- Clinical Neurology
- Cellular and Molecular Neuroscience
