Avocado oil extract modulates auditory hair cell function through the regulation of amino acid biosynthesis genes

Youn Hee Nam, Isabel Rodriguez, Seo Yeon Jeong, Thu Nguyen Minh Pham, Wanlapa Nuankaew, Yun Hee Kim, Rodrigo Castañeda, Seo Yule Jeong, Min Seon Park, Kye Wan Lee, Jung Suk Lee, Do Hoon Kim, Yu Hwa Park, Seung Hyun Kim, In Seok Moon, Se Young Choung, Bin Na Hong, Kwang Won Jeong, Tong Ho Kang

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Sensorineural hearing loss (SNHL) is one of the most common causes of disability, affecting over 466 million people worldwide. However, prevention or therapy of SNHL has not been widely studied. Avocado oil has shown many health benefits but it has not yet been studied in regards to SNHL. Therefore, we aimed to investigate the efficacy of avocado oil on SNHL in vitro and in vivo and elucidate its mode of action. For the present study, we used enhanced functional avocado oil extract (DKB122). DKB122 led to recovery of otic hair cells in zebrafish after neomycin-induced otic cell damage. Also, DKB122 improved auditory sensory transmission function in a mouse model of noise induced-hearing loss and protected sensory hair cells in the cochlea. In addition, RNA sequencing was performed to elucidate the mechanism involved. KEGG pathway enrichment analysis of differentially expressed genes showed that DKB122 protected House Ear Institute-Organ of Corti 1 (HEI-OC1) cells against neomycin-related alterations in gene expression due to oxidative stress, cytokine production and protein synthesis.

Original languageEnglish
JournalNutrients
Volume11
Issue number1
DOIs
Publication statusPublished - 2019 Jan

Fingerprint

avocado oil
Auditory Hair Cells
Persea
Sensorineural Hearing Loss
hearing
hairs
Oils
biosynthesis
Ear
Amino Acids
amino acids
Neomycin
extracts
ears
neomycin
Genes
genes
cells
RNA Sequence Analysis
Noise-Induced Hearing Loss

All Science Journal Classification (ASJC) codes

  • Food Science
  • Nutrition and Dietetics

Cite this

Nam, Y. H., Rodriguez, I., Jeong, S. Y., Pham, T. N. M., Nuankaew, W., Kim, Y. H., ... Kang, T. H. (2019). Avocado oil extract modulates auditory hair cell function through the regulation of amino acid biosynthesis genes. Nutrients, 11(1). https://doi.org/10.3390/nu11010113
Nam, Youn Hee ; Rodriguez, Isabel ; Jeong, Seo Yeon ; Pham, Thu Nguyen Minh ; Nuankaew, Wanlapa ; Kim, Yun Hee ; Castañeda, Rodrigo ; Jeong, Seo Yule ; Park, Min Seon ; Lee, Kye Wan ; Lee, Jung Suk ; Kim, Do Hoon ; Park, Yu Hwa ; Kim, Seung Hyun ; Moon, In Seok ; Choung, Se Young ; Hong, Bin Na ; Jeong, Kwang Won ; Kang, Tong Ho. / Avocado oil extract modulates auditory hair cell function through the regulation of amino acid biosynthesis genes. In: Nutrients. 2019 ; Vol. 11, No. 1.
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abstract = "Sensorineural hearing loss (SNHL) is one of the most common causes of disability, affecting over 466 million people worldwide. However, prevention or therapy of SNHL has not been widely studied. Avocado oil has shown many health benefits but it has not yet been studied in regards to SNHL. Therefore, we aimed to investigate the efficacy of avocado oil on SNHL in vitro and in vivo and elucidate its mode of action. For the present study, we used enhanced functional avocado oil extract (DKB122). DKB122 led to recovery of otic hair cells in zebrafish after neomycin-induced otic cell damage. Also, DKB122 improved auditory sensory transmission function in a mouse model of noise induced-hearing loss and protected sensory hair cells in the cochlea. In addition, RNA sequencing was performed to elucidate the mechanism involved. KEGG pathway enrichment analysis of differentially expressed genes showed that DKB122 protected House Ear Institute-Organ of Corti 1 (HEI-OC1) cells against neomycin-related alterations in gene expression due to oxidative stress, cytokine production and protein synthesis.",
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Nam, YH, Rodriguez, I, Jeong, SY, Pham, TNM, Nuankaew, W, Kim, YH, Castañeda, R, Jeong, SY, Park, MS, Lee, KW, Lee, JS, Kim, DH, Park, YH, Kim, SH, Moon, IS, Choung, SY, Hong, BN, Jeong, KW & Kang, TH 2019, 'Avocado oil extract modulates auditory hair cell function through the regulation of amino acid biosynthesis genes', Nutrients, vol. 11, no. 1. https://doi.org/10.3390/nu11010113

Avocado oil extract modulates auditory hair cell function through the regulation of amino acid biosynthesis genes. / Nam, Youn Hee; Rodriguez, Isabel; Jeong, Seo Yeon; Pham, Thu Nguyen Minh; Nuankaew, Wanlapa; Kim, Yun Hee; Castañeda, Rodrigo; Jeong, Seo Yule; Park, Min Seon; Lee, Kye Wan; Lee, Jung Suk; Kim, Do Hoon; Park, Yu Hwa; Kim, Seung Hyun; Moon, In Seok; Choung, Se Young; Hong, Bin Na; Jeong, Kwang Won; Kang, Tong Ho.

In: Nutrients, Vol. 11, No. 1, 01.2019.

Research output: Contribution to journalArticle

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AU - Nam, Youn Hee

AU - Rodriguez, Isabel

AU - Jeong, Seo Yeon

AU - Pham, Thu Nguyen Minh

AU - Nuankaew, Wanlapa

AU - Kim, Yun Hee

AU - Castañeda, Rodrigo

AU - Jeong, Seo Yule

AU - Park, Min Seon

AU - Lee, Kye Wan

AU - Lee, Jung Suk

AU - Kim, Do Hoon

AU - Park, Yu Hwa

AU - Kim, Seung Hyun

AU - Moon, In Seok

AU - Choung, Se Young

AU - Hong, Bin Na

AU - Jeong, Kwang Won

AU - Kang, Tong Ho

PY - 2019/1

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N2 - Sensorineural hearing loss (SNHL) is one of the most common causes of disability, affecting over 466 million people worldwide. However, prevention or therapy of SNHL has not been widely studied. Avocado oil has shown many health benefits but it has not yet been studied in regards to SNHL. Therefore, we aimed to investigate the efficacy of avocado oil on SNHL in vitro and in vivo and elucidate its mode of action. For the present study, we used enhanced functional avocado oil extract (DKB122). DKB122 led to recovery of otic hair cells in zebrafish after neomycin-induced otic cell damage. Also, DKB122 improved auditory sensory transmission function in a mouse model of noise induced-hearing loss and protected sensory hair cells in the cochlea. In addition, RNA sequencing was performed to elucidate the mechanism involved. KEGG pathway enrichment analysis of differentially expressed genes showed that DKB122 protected House Ear Institute-Organ of Corti 1 (HEI-OC1) cells against neomycin-related alterations in gene expression due to oxidative stress, cytokine production and protein synthesis.

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