Avoidance therapy in reactive dye-induced occupational asthma: Long-term follow-up

Jungwon Park, Joo Young Yang, Cheol Woo Kim, Kyu Sang Kim, Chein Soo Hong

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Background: Previous studies reported that early diagnosis and avoidance therapy are the most important factors for prevention of permanent lung impairment; however, few studies have evaluated the long-term prognosis of reactive dye-induced occupational asthma (RD-OA). Objective: To evaluate the long-term outcomes of RD-OA. Methods: Methacholine airway hyperresponsiveness (AHR) and lung functions were evaluated and compared in 26 patients with RD-OA at the time of diagnosis and after complete avoidance of the causative agents. Patients with continued (n = 13) or remitted (n = 6) AHR were further monitored for up to a mean ± SD of 8.7 ± 1.8 years. Results: The AHR resolved in 10 (38%) of 26 patients a mean ± SD of 2.2 ± 1.3 years after complete avoidance of RDs; however, prebronchodilator forced expiratory volume in 1 second (FEV 1 ) values were not different. Levels of IgE specific to the RD-human serum albumin complex were markedly decreased at first follow-up in 5 RD-atopic patients from whom paired serum samples were compared (P = .02). The AHR disappeared in an additional 5 patients and improved in 4 by the second follow-up. The FEV 1 values also improved compared with diagnosis and first follow-up levels. Favorable prognosis was associated with early diagnosis of RD-OA and complete avoidance of the causative agent. No association was found with smoking history, latent periods, the presence of RD specific IgE, baseline provocation concentration that caused a decrease in FEV 1 of 20%, or FEV 1 . Conclusions: Early diagnosis and avoidance therapy are the most important prognostic factors in RD-OA. The AHR and lung function of patients with RD-OA can sometimes be recovered steadily and slowly through avoidance measures.

Original languageEnglish
Pages (from-to)551-556
Number of pages6
JournalAnnals of Allergy, Asthma and Immunology
Volume97
Issue number4
DOIs
Publication statusPublished - 2006 Jan 1

Fingerprint

Occupational Asthma
Coloring Agents
Forced Expiratory Volume
Early Diagnosis
Lung
Immunoglobulin E
Therapeutics
Methacholine Chloride
Serum Albumin
Smoking
History
Serum

All Science Journal Classification (ASJC) codes

  • Immunology and Allergy
  • Immunology
  • Pulmonary and Respiratory Medicine

Cite this

Park, Jungwon ; Yang, Joo Young ; Kim, Cheol Woo ; Kim, Kyu Sang ; Hong, Chein Soo. / Avoidance therapy in reactive dye-induced occupational asthma : Long-term follow-up. In: Annals of Allergy, Asthma and Immunology. 2006 ; Vol. 97, No. 4. pp. 551-556.
@article{7b8aa1c3a0fb40c1b458d0f753f6a377,
title = "Avoidance therapy in reactive dye-induced occupational asthma: Long-term follow-up",
abstract = "Background: Previous studies reported that early diagnosis and avoidance therapy are the most important factors for prevention of permanent lung impairment; however, few studies have evaluated the long-term prognosis of reactive dye-induced occupational asthma (RD-OA). Objective: To evaluate the long-term outcomes of RD-OA. Methods: Methacholine airway hyperresponsiveness (AHR) and lung functions were evaluated and compared in 26 patients with RD-OA at the time of diagnosis and after complete avoidance of the causative agents. Patients with continued (n = 13) or remitted (n = 6) AHR were further monitored for up to a mean ± SD of 8.7 ± 1.8 years. Results: The AHR resolved in 10 (38{\%}) of 26 patients a mean ± SD of 2.2 ± 1.3 years after complete avoidance of RDs; however, prebronchodilator forced expiratory volume in 1 second (FEV 1 ) values were not different. Levels of IgE specific to the RD-human serum albumin complex were markedly decreased at first follow-up in 5 RD-atopic patients from whom paired serum samples were compared (P = .02). The AHR disappeared in an additional 5 patients and improved in 4 by the second follow-up. The FEV 1 values also improved compared with diagnosis and first follow-up levels. Favorable prognosis was associated with early diagnosis of RD-OA and complete avoidance of the causative agent. No association was found with smoking history, latent periods, the presence of RD specific IgE, baseline provocation concentration that caused a decrease in FEV 1 of 20{\%}, or FEV 1 . Conclusions: Early diagnosis and avoidance therapy are the most important prognostic factors in RD-OA. The AHR and lung function of patients with RD-OA can sometimes be recovered steadily and slowly through avoidance measures.",
author = "Jungwon Park and Yang, {Joo Young} and Kim, {Cheol Woo} and Kim, {Kyu Sang} and Hong, {Chein Soo}",
year = "2006",
month = "1",
day = "1",
doi = "10.1016/S1081-1206(10)60949-0",
language = "English",
volume = "97",
pages = "551--556",
journal = "Annals of Allergy, Asthma and Immunology",
issn = "1081-1206",
publisher = "American College of Allergy, Asthma and Immunology",
number = "4",

}

Avoidance therapy in reactive dye-induced occupational asthma : Long-term follow-up. / Park, Jungwon; Yang, Joo Young; Kim, Cheol Woo; Kim, Kyu Sang; Hong, Chein Soo.

In: Annals of Allergy, Asthma and Immunology, Vol. 97, No. 4, 01.01.2006, p. 551-556.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Avoidance therapy in reactive dye-induced occupational asthma

T2 - Long-term follow-up

AU - Park, Jungwon

AU - Yang, Joo Young

AU - Kim, Cheol Woo

AU - Kim, Kyu Sang

AU - Hong, Chein Soo

PY - 2006/1/1

Y1 - 2006/1/1

N2 - Background: Previous studies reported that early diagnosis and avoidance therapy are the most important factors for prevention of permanent lung impairment; however, few studies have evaluated the long-term prognosis of reactive dye-induced occupational asthma (RD-OA). Objective: To evaluate the long-term outcomes of RD-OA. Methods: Methacholine airway hyperresponsiveness (AHR) and lung functions were evaluated and compared in 26 patients with RD-OA at the time of diagnosis and after complete avoidance of the causative agents. Patients with continued (n = 13) or remitted (n = 6) AHR were further monitored for up to a mean ± SD of 8.7 ± 1.8 years. Results: The AHR resolved in 10 (38%) of 26 patients a mean ± SD of 2.2 ± 1.3 years after complete avoidance of RDs; however, prebronchodilator forced expiratory volume in 1 second (FEV 1 ) values were not different. Levels of IgE specific to the RD-human serum albumin complex were markedly decreased at first follow-up in 5 RD-atopic patients from whom paired serum samples were compared (P = .02). The AHR disappeared in an additional 5 patients and improved in 4 by the second follow-up. The FEV 1 values also improved compared with diagnosis and first follow-up levels. Favorable prognosis was associated with early diagnosis of RD-OA and complete avoidance of the causative agent. No association was found with smoking history, latent periods, the presence of RD specific IgE, baseline provocation concentration that caused a decrease in FEV 1 of 20%, or FEV 1 . Conclusions: Early diagnosis and avoidance therapy are the most important prognostic factors in RD-OA. The AHR and lung function of patients with RD-OA can sometimes be recovered steadily and slowly through avoidance measures.

AB - Background: Previous studies reported that early diagnosis and avoidance therapy are the most important factors for prevention of permanent lung impairment; however, few studies have evaluated the long-term prognosis of reactive dye-induced occupational asthma (RD-OA). Objective: To evaluate the long-term outcomes of RD-OA. Methods: Methacholine airway hyperresponsiveness (AHR) and lung functions were evaluated and compared in 26 patients with RD-OA at the time of diagnosis and after complete avoidance of the causative agents. Patients with continued (n = 13) or remitted (n = 6) AHR were further monitored for up to a mean ± SD of 8.7 ± 1.8 years. Results: The AHR resolved in 10 (38%) of 26 patients a mean ± SD of 2.2 ± 1.3 years after complete avoidance of RDs; however, prebronchodilator forced expiratory volume in 1 second (FEV 1 ) values were not different. Levels of IgE specific to the RD-human serum albumin complex were markedly decreased at first follow-up in 5 RD-atopic patients from whom paired serum samples were compared (P = .02). The AHR disappeared in an additional 5 patients and improved in 4 by the second follow-up. The FEV 1 values also improved compared with diagnosis and first follow-up levels. Favorable prognosis was associated with early diagnosis of RD-OA and complete avoidance of the causative agent. No association was found with smoking history, latent periods, the presence of RD specific IgE, baseline provocation concentration that caused a decrease in FEV 1 of 20%, or FEV 1 . Conclusions: Early diagnosis and avoidance therapy are the most important prognostic factors in RD-OA. The AHR and lung function of patients with RD-OA can sometimes be recovered steadily and slowly through avoidance measures.

UR - http://www.scopus.com/inward/record.url?scp=33750133180&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=33750133180&partnerID=8YFLogxK

U2 - 10.1016/S1081-1206(10)60949-0

DO - 10.1016/S1081-1206(10)60949-0

M3 - Article

C2 - 17069113

AN - SCOPUS:33750133180

VL - 97

SP - 551

EP - 556

JO - Annals of Allergy, Asthma and Immunology

JF - Annals of Allergy, Asthma and Immunology

SN - 1081-1206

IS - 4

ER -