Axillary lymph node metastasis: CA-15-3 and carcinoembryonic antigen concentrations in fine-needle aspirates for preoperative diagnosis in patients with breast cancer

Min Jung Kim, Byeong Woo Park, Jong Baeck Lim, Hyon Suk Kim, Jin Young Kwak, Soo Jin Kim, Sung Hee Park, Yu Mee Sohn, Hee Jung Moon, Eun Kyung Kim

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Abstract

Purpose: To assess whether concentrations of the tumor markers breast cancer antigen 15-3 (CA-15-3) and carcinoembryonic antigen (CEA) in fine-needle aspirates (FNAs) differ between benign and malignant lymph nodes and whether FNA concentrations of the tumor markers can improve the sensitivity of axillary lymph node (ALN) FNA in patients with breast cancer. Materials and Methods: An Institutional Review Board approved this study. All subjects gave written informed consent. Ultrasonographically (US)-guided FNA was performed for 134 ALNs in 134 women (mean age, 49.6 years; range, 28-92 years) with breast cancer. Immediately after obtaining an FNA cytology specimen, the needle was rinsed with 1 mL of normal saline solution. CEA and CA-15-3 concentrations were measured in the washout. Of the 134 ALNs, 86 were malignant and 48 were benign. Sensitivity of FNA cytology alone was compared with the sensitivity of FNA cytology and CEA and CA-15-3 FNA concentrations. Results: Patients with a positive metastatic diagnosis had significantly higher FNA concentrations of CEA and CA-15-3 than did those with a negative diagnosis (both P =.02). FNA cytology sensitivity was 87.2%, and the combined sensitivity of FNA cytology and FNA tumor marker concentrations was 96.5% ( P =.01). Conclusion: Evaluation of CEA and CA-15-3 concentrations in FNA could be helpful for the preoperative diagnosis of ALN metastasis in patients with breast cancer.

Original languageEnglish
Pages (from-to)691-697
Number of pages7
JournalRadiology
Volume254
Issue number3
DOIs
Publication statusPublished - 2010 Mar 1

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Carcinoembryonic Antigen
Needles
Lymph Nodes
Breast Neoplasms
Neoplasm Metastasis
Antigens
Neoplasms
Cell Biology
Tumor Biomarkers
Research Ethics Committees
Informed Consent
Sodium Chloride

All Science Journal Classification (ASJC) codes

  • Radiology Nuclear Medicine and imaging

Cite this

@article{8be3f7d1556944838307ed5da8c54396,
title = "Axillary lymph node metastasis: CA-15-3 and carcinoembryonic antigen concentrations in fine-needle aspirates for preoperative diagnosis in patients with breast cancer",
abstract = "Purpose: To assess whether concentrations of the tumor markers breast cancer antigen 15-3 (CA-15-3) and carcinoembryonic antigen (CEA) in fine-needle aspirates (FNAs) differ between benign and malignant lymph nodes and whether FNA concentrations of the tumor markers can improve the sensitivity of axillary lymph node (ALN) FNA in patients with breast cancer. Materials and Methods: An Institutional Review Board approved this study. All subjects gave written informed consent. Ultrasonographically (US)-guided FNA was performed for 134 ALNs in 134 women (mean age, 49.6 years; range, 28-92 years) with breast cancer. Immediately after obtaining an FNA cytology specimen, the needle was rinsed with 1 mL of normal saline solution. CEA and CA-15-3 concentrations were measured in the washout. Of the 134 ALNs, 86 were malignant and 48 were benign. Sensitivity of FNA cytology alone was compared with the sensitivity of FNA cytology and CEA and CA-15-3 FNA concentrations. Results: Patients with a positive metastatic diagnosis had significantly higher FNA concentrations of CEA and CA-15-3 than did those with a negative diagnosis (both P =.02). FNA cytology sensitivity was 87.2{\%}, and the combined sensitivity of FNA cytology and FNA tumor marker concentrations was 96.5{\%} ( P =.01). Conclusion: Evaluation of CEA and CA-15-3 concentrations in FNA could be helpful for the preoperative diagnosis of ALN metastasis in patients with breast cancer.",
author = "Kim, {Min Jung} and Park, {Byeong Woo} and Lim, {Jong Baeck} and Kim, {Hyon Suk} and Kwak, {Jin Young} and Kim, {Soo Jin} and Park, {Sung Hee} and Sohn, {Yu Mee} and Moon, {Hee Jung} and Kim, {Eun Kyung}",
year = "2010",
month = "3",
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doi = "10.1148/radiol.09091031",
language = "English",
volume = "254",
pages = "691--697",
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Axillary lymph node metastasis : CA-15-3 and carcinoembryonic antigen concentrations in fine-needle aspirates for preoperative diagnosis in patients with breast cancer. / Kim, Min Jung; Park, Byeong Woo; Lim, Jong Baeck; Kim, Hyon Suk; Kwak, Jin Young; Kim, Soo Jin; Park, Sung Hee; Sohn, Yu Mee; Moon, Hee Jung; Kim, Eun Kyung.

In: Radiology, Vol. 254, No. 3, 01.03.2010, p. 691-697.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Axillary lymph node metastasis

T2 - CA-15-3 and carcinoembryonic antigen concentrations in fine-needle aspirates for preoperative diagnosis in patients with breast cancer

AU - Kim, Min Jung

AU - Park, Byeong Woo

AU - Lim, Jong Baeck

AU - Kim, Hyon Suk

AU - Kwak, Jin Young

AU - Kim, Soo Jin

AU - Park, Sung Hee

AU - Sohn, Yu Mee

AU - Moon, Hee Jung

AU - Kim, Eun Kyung

PY - 2010/3/1

Y1 - 2010/3/1

N2 - Purpose: To assess whether concentrations of the tumor markers breast cancer antigen 15-3 (CA-15-3) and carcinoembryonic antigen (CEA) in fine-needle aspirates (FNAs) differ between benign and malignant lymph nodes and whether FNA concentrations of the tumor markers can improve the sensitivity of axillary lymph node (ALN) FNA in patients with breast cancer. Materials and Methods: An Institutional Review Board approved this study. All subjects gave written informed consent. Ultrasonographically (US)-guided FNA was performed for 134 ALNs in 134 women (mean age, 49.6 years; range, 28-92 years) with breast cancer. Immediately after obtaining an FNA cytology specimen, the needle was rinsed with 1 mL of normal saline solution. CEA and CA-15-3 concentrations were measured in the washout. Of the 134 ALNs, 86 were malignant and 48 were benign. Sensitivity of FNA cytology alone was compared with the sensitivity of FNA cytology and CEA and CA-15-3 FNA concentrations. Results: Patients with a positive metastatic diagnosis had significantly higher FNA concentrations of CEA and CA-15-3 than did those with a negative diagnosis (both P =.02). FNA cytology sensitivity was 87.2%, and the combined sensitivity of FNA cytology and FNA tumor marker concentrations was 96.5% ( P =.01). Conclusion: Evaluation of CEA and CA-15-3 concentrations in FNA could be helpful for the preoperative diagnosis of ALN metastasis in patients with breast cancer.

AB - Purpose: To assess whether concentrations of the tumor markers breast cancer antigen 15-3 (CA-15-3) and carcinoembryonic antigen (CEA) in fine-needle aspirates (FNAs) differ between benign and malignant lymph nodes and whether FNA concentrations of the tumor markers can improve the sensitivity of axillary lymph node (ALN) FNA in patients with breast cancer. Materials and Methods: An Institutional Review Board approved this study. All subjects gave written informed consent. Ultrasonographically (US)-guided FNA was performed for 134 ALNs in 134 women (mean age, 49.6 years; range, 28-92 years) with breast cancer. Immediately after obtaining an FNA cytology specimen, the needle was rinsed with 1 mL of normal saline solution. CEA and CA-15-3 concentrations were measured in the washout. Of the 134 ALNs, 86 were malignant and 48 were benign. Sensitivity of FNA cytology alone was compared with the sensitivity of FNA cytology and CEA and CA-15-3 FNA concentrations. Results: Patients with a positive metastatic diagnosis had significantly higher FNA concentrations of CEA and CA-15-3 than did those with a negative diagnosis (both P =.02). FNA cytology sensitivity was 87.2%, and the combined sensitivity of FNA cytology and FNA tumor marker concentrations was 96.5% ( P =.01). Conclusion: Evaluation of CEA and CA-15-3 concentrations in FNA could be helpful for the preoperative diagnosis of ALN metastasis in patients with breast cancer.

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