Azide-alkyne huisgen [3+2] cycloaddition using CuO nanoparticles

Hyunje Woo, Hyuntae Kang, Aram Kim, Seongwan Jang, Ji Chan Park, Sungkyun Park, Byeong Su Kim, Hyunjoon Song, Kang Hyun Park

Research output: Contribution to journalReview articlepeer-review

45 Citations (Scopus)


Recent developments in the synthesis of CuO nanoparticles (NPs) and their application to the [3+2] cycloaddition of azides with terminal alkynes are reviewed. With respect to the importance of click chemistry, CuO hollow NPs, CuO hollow NPs on acetylene black, water-soluble double-hydrophilic block copolymer (DHBC) nanoreactors and ZnO-CuO hybrid NPs were synthesized. Non-conventional energy sources such as microwaves and ultrasound were also applied to these click reactions, and good catalytic activity with high regioselectivity was observed. CuO hollow NPs on acetylene black can be recycled nine times without any loss of activity, and water-soluble DHBC nanoreactors have been developed for an environmentally friendly process.

Original languageEnglish
Pages (from-to)13235-13252
Number of pages18
Issue number11
Publication statusPublished - 2012 Nov

All Science Journal Classification (ASJC) codes

  • Analytical Chemistry
  • Chemistry (miscellaneous)
  • Molecular Medicine
  • Pharmaceutical Science
  • Drug Discovery
  • Physical and Theoretical Chemistry
  • Organic Chemistry


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