B-type natriuretic peptide is not a prognostic marker in acute dyspneic patients with renal insufficiency

Min Soo Ahn, Byung Su Yoo, Jun Won Lee, Ji Hyun Lee, Young Jin Youn, Sung Gyun Ahn, Jang Young Kim, Seung Hwan Lee, Junghan Yoon

Research output: Contribution to journalArticle

Abstract

Objective: The prognostic value of BNP levels in patients presenting with acute dyspnea and renal insufficiency (RI) has been questioned. We evaluated the long-term prognostic value of BNP levels in dyspneic patients with RI. Methods: Of 1,207 consecutive participants who presented with acute dyspnea, patients with mild-to-severe RI (15<eGFR<90mL/min/1.73m2) were recruited. During follow-up, major adverse events (MAEs), i.e., all causes of death and rehospitalization, because of worsening heart failure were evaluated. Results: A total of 408 patients with acute dyspnea and RI were evaluated. During a 30.1± 31.7-month follow-up, cardiac death (n=26), non-cardiac death (n=28) and hospital re-admission (n=117) was observed in 35% of patients (n=143). The adjusted multiple Cox regression analysis showed that left atrial diameter was a significant prognostic maker of MAEs (relative risk, 1.18; 95% confidence interval, 1.03-1.34; p=0.02). Conclusions: We focused on subjects with acute dyspnea and renal failure who required hospital admission, BNP level was not a prognostic marker but left atrial diameter as a surrogate marker of diastolic dysfunction was an independent prognostic maker of all cause of death and rehospitalization due to aggravated heart failure.

Original languageEnglish
Pages (from-to)3755-3769
Number of pages15
JournalExperimental and Clinical Cardiology
Volume20
Issue number6
Publication statusPublished - 2014

All Science Journal Classification (ASJC) codes

  • Physiology
  • Cardiology and Cardiovascular Medicine
  • Physiology (medical)

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