Bacterial Lectin-Targeting Glycoconjugates for Selective Elimination of Pathogenic Bacteria

Ji Young Hyun; Chang Hee Lee; Hosoowi Lee; Woo Dong Jang; Injae Shin

doi:10.1021/acsmacrolett.0c00454

Bacterial Lectin-Targeting Glycoconjugates for Selective Elimination of Pathogenic Bacteria

Ji Young Hyun, Chang Hee Lee, Hosoowi Lee, Woo Dong Jang, Injae Shin

Department of Chemistry

Research output: Contribution to journal › Article › peer-review

7 Citations (Scopus)

Abstract

Herein we report a strategy to eradicate pathogenic bacteria selectively, which utilizes bacterial lectin-targeting glycoconjugates that contain an epitope or a photosensitizer to promote antibody-dependent cellular cytotoxicity (ADCC) or photodynamic therapy (PDT), respectively. Our results show that death promoted by using the designed synthetic glycoconjugates coupled with ADCC or PDT takes place selectively in pathogenic bacteria expressing lectins on their surfaces.

Original language	English
Pages (from-to)	1429-1432
Number of pages	4
Journal	ACS Macro Letters
Volume	9
Issue number	10
DOIs	https://doi.org/10.1021/acsmacrolett.0c00454
Publication status	Published - 2020 Oct 20

Bibliographical note

Funding Information:
This study was supported financially by the National Research Foundation of Korea (Grant Nos. 2020R1A2C3003462 to I.S. and 2020R1A2C3004520 to W.-D.J.).

Publisher Copyright:
©

All Science Journal Classification (ASJC) codes

Organic Chemistry
Polymers and Plastics
Inorganic Chemistry
Materials Chemistry

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10.1021/acsmacrolett.0c00454

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abstract = "Herein we report a strategy to eradicate pathogenic bacteria selectively, which utilizes bacterial lectin-targeting glycoconjugates that contain an epitope or a photosensitizer to promote antibody-dependent cellular cytotoxicity (ADCC) or photodynamic therapy (PDT), respectively. Our results show that death promoted by using the designed synthetic glycoconjugates coupled with ADCC or PDT takes place selectively in pathogenic bacteria expressing lectins on their surfaces.",

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AU - Shin, Injae

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N2 - Herein we report a strategy to eradicate pathogenic bacteria selectively, which utilizes bacterial lectin-targeting glycoconjugates that contain an epitope or a photosensitizer to promote antibody-dependent cellular cytotoxicity (ADCC) or photodynamic therapy (PDT), respectively. Our results show that death promoted by using the designed synthetic glycoconjugates coupled with ADCC or PDT takes place selectively in pathogenic bacteria expressing lectins on their surfaces.

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Bacterial Lectin-Targeting Glycoconjugates for Selective Elimination of Pathogenic Bacteria

Abstract

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