Bactericidal and virucidal ultrathin films assembled layer by layer from polycationic N-alkylated polyethylenimines and polyanions

Sze Yinn Wong, Qing Li, Jovana Veselinovic, Byeong Su Kim, Alexander M. Klibanov, Paula T. Hammond

Research output: Contribution to journalArticlepeer-review

93 Citations (Scopus)

Abstract

In this work, we designed contact-killing ionically cross-linked polymeric thin films using Layer-by-Layer (LbL) technology. A polycation, N,N-dodecyl,methyl-polyethylenimine, with microbicidal activity was layered with a polyanion, such as poly(acrylic acid), to create LbL films highly effective against both airborne and waterborne Escherichia coli and Staphylococcus aureus (Gram negative and positive bacteria, respectively), as well as influenza A/WSN (H1N1) virus. The dependence of the microbicidal activity on the pH during and post-assembly of LbL film formation, the nature of the polycation and polyanion, the number of layers in the LbL film, and other experimental variables was investigated quantitatively.

Original languageEnglish
Pages (from-to)4079-4087
Number of pages9
JournalBiomaterials
Volume31
Issue number14
DOIs
Publication statusPublished - 2010 May

Bibliographical note

Funding Information:
We thank members of the Chen and Klibanov laboratories at MIT, especially Bryan Hsu, for help with handling influenza virus and synthesis of the polycations. We also thank Jinkee Hong, Steve Kooi, and Yunhong Min for help with SEM, FT-IR, and AFM respectively. This work was funded by the United States Army through the Institute for Soldier Nanotechnologies at the Massachusetts Institute of Technology.

All Science Journal Classification (ASJC) codes

  • Bioengineering
  • Ceramics and Composites
  • Biophysics
  • Biomaterials
  • Mechanics of Materials

Fingerprint

Dive into the research topics of 'Bactericidal and virucidal ultrathin films assembled layer by layer from polycationic N-alkylated polyethylenimines and polyanions'. Together they form a unique fingerprint.

Cite this