Bactericidal and virucidal ultrathin films assembled layer by layer from polycationic N-alkylated polyethylenimines and polyanions

Sze Yinn Wong, Qing Li, Jovana Veselinovic, Byeong Su Kim, Alexander M. Klibanov, Paula T. Hammond

Research output: Contribution to journalArticle

76 Citations (Scopus)

Abstract

In this work, we designed contact-killing ionically cross-linked polymeric thin films using Layer-by-Layer (LbL) technology. A polycation, N,N-dodecyl,methyl-polyethylenimine, with microbicidal activity was layered with a polyanion, such as poly(acrylic acid), to create LbL films highly effective against both airborne and waterborne Escherichia coli and Staphylococcus aureus (Gram negative and positive bacteria, respectively), as well as influenza A/WSN (H1N1) virus. The dependence of the microbicidal activity on the pH during and post-assembly of LbL film formation, the nature of the polycation and polyanion, the number of layers in the LbL film, and other experimental variables was investigated quantitatively.

Original languageEnglish
Pages (from-to)4079-4087
Number of pages9
JournalBiomaterials
Volume31
Issue number14
DOIs
Publication statusPublished - 2010 May 1

Fingerprint

Polyethyleneimine
carbopol 940
Ultrathin films
H1N1 Subtype Influenza A Virus
Gram-Positive Bacteria
Gram-Negative Bacteria
Human Influenza
Staphylococcus aureus
Escherichia coli
Technology
Viruses
Polymer films
Acrylics
Bacteria
Thin films
Acids
polycations
polyanions
N,N-dodecyl,methyl-polyethylenimine

All Science Journal Classification (ASJC) codes

  • Biomaterials
  • Bioengineering
  • Ceramics and Composites
  • Mechanics of Materials
  • Biophysics

Cite this

Wong, Sze Yinn ; Li, Qing ; Veselinovic, Jovana ; Kim, Byeong Su ; Klibanov, Alexander M. ; Hammond, Paula T. / Bactericidal and virucidal ultrathin films assembled layer by layer from polycationic N-alkylated polyethylenimines and polyanions. In: Biomaterials. 2010 ; Vol. 31, No. 14. pp. 4079-4087.
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Bactericidal and virucidal ultrathin films assembled layer by layer from polycationic N-alkylated polyethylenimines and polyanions. / Wong, Sze Yinn; Li, Qing; Veselinovic, Jovana; Kim, Byeong Su; Klibanov, Alexander M.; Hammond, Paula T.

In: Biomaterials, Vol. 31, No. 14, 01.05.2010, p. 4079-4087.

Research output: Contribution to journalArticle

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