In this work, we designed contact-killing ionically cross-linked polymeric thin films using Layer-by-Layer (LbL) technology. A polycation, N,N-dodecyl,methyl-polyethylenimine, with microbicidal activity was layered with a polyanion, such as poly(acrylic acid), to create LbL films highly effective against both airborne and waterborne Escherichia coli and Staphylococcus aureus (Gram negative and positive bacteria, respectively), as well as influenza A/WSN (H1N1) virus. The dependence of the microbicidal activity on the pH during and post-assembly of LbL film formation, the nature of the polycation and polyanion, the number of layers in the LbL film, and other experimental variables was investigated quantitatively.
|Number of pages||9|
|Publication status||Published - 2010 May|
Bibliographical noteFunding Information:
We thank members of the Chen and Klibanov laboratories at MIT, especially Bryan Hsu, for help with handling influenza virus and synthesis of the polycations. We also thank Jinkee Hong, Steve Kooi, and Yunhong Min for help with SEM, FT-IR, and AFM respectively. This work was funded by the United States Army through the Institute for Soldier Nanotechnologies at the Massachusetts Institute of Technology.
All Science Journal Classification (ASJC) codes
- Ceramics and Composites
- Mechanics of Materials