Balsamic vinegar improves high fat-induced beta cell dysfunction via beta cell ABCA1

Hannah Seok, Ji Young Lee, Eun Mi Park, Se Eun Park, Jae Hyuk Lee, Seungtaek Lim, Byung Wan Lee, Eun Seok Kang, Hyun Chul Lee, Bong Soo Cha

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Background: The aim of this study was to investigate the effects of balsamic vinegar on β-cell dysfunction. Methods: In this study, 28-week-old Otsuka Long-Evans Tokushima Fatty (OLETF) rats were fed a normal chow diet or a highfat diet (HFD) and were provided with tap water or dilute balsamic vinegar for 4 weeks. Oral glucose tolerance tests and histopathological analyses were performed thereafter. Results: In rats fed both the both chow diet and the HFD, the rats given balsamic vinegar showed increased insulin staining in islets compared with tap water administered rats. Balsamic vinegar administration also increased β-cell ATP-binding cassette transporter subfamily A member 1 (ABCA1) expression in islets and decreased cholesterol levels. Conclusion: These findings provide the first evidence for an anti-diabetic effect of balsamic vinegar through improvement of β-cell function via increasing β-cell ABCA1 expression.

Original languageEnglish
Pages (from-to)275-279
Number of pages5
JournalDiabetes and Metabolism Journal
Volume36
Issue number4
DOIs
Publication statusPublished - 2012 Aug 1

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ATP-Binding Cassette Transporters
Acetic Acid
Fats
Diet
Inbred OLETF Rats
Water
Glucose Tolerance Test
Cholesterol
Insulin
Staining and Labeling

All Science Journal Classification (ASJC) codes

  • Endocrinology, Diabetes and Metabolism

Cite this

Seok, H., Lee, J. Y., Park, E. M., Park, S. E., Lee, J. H., Lim, S., ... Cha, B. S. (2012). Balsamic vinegar improves high fat-induced beta cell dysfunction via beta cell ABCA1. Diabetes and Metabolism Journal, 36(4), 275-279. https://doi.org/10.4093/dmj.2012.36.4.275
Seok, Hannah ; Lee, Ji Young ; Park, Eun Mi ; Park, Se Eun ; Lee, Jae Hyuk ; Lim, Seungtaek ; Lee, Byung Wan ; Kang, Eun Seok ; Lee, Hyun Chul ; Cha, Bong Soo. / Balsamic vinegar improves high fat-induced beta cell dysfunction via beta cell ABCA1. In: Diabetes and Metabolism Journal. 2012 ; Vol. 36, No. 4. pp. 275-279.
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Seok, H, Lee, JY, Park, EM, Park, SE, Lee, JH, Lim, S, Lee, BW, Kang, ES, Lee, HC & Cha, BS 2012, 'Balsamic vinegar improves high fat-induced beta cell dysfunction via beta cell ABCA1', Diabetes and Metabolism Journal, vol. 36, no. 4, pp. 275-279. https://doi.org/10.4093/dmj.2012.36.4.275

Balsamic vinegar improves high fat-induced beta cell dysfunction via beta cell ABCA1. / Seok, Hannah; Lee, Ji Young; Park, Eun Mi; Park, Se Eun; Lee, Jae Hyuk; Lim, Seungtaek; Lee, Byung Wan; Kang, Eun Seok; Lee, Hyun Chul; Cha, Bong Soo.

In: Diabetes and Metabolism Journal, Vol. 36, No. 4, 01.08.2012, p. 275-279.

Research output: Contribution to journalArticle

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AU - Seok, Hannah

AU - Lee, Ji Young

AU - Park, Eun Mi

AU - Park, Se Eun

AU - Lee, Jae Hyuk

AU - Lim, Seungtaek

AU - Lee, Byung Wan

AU - Kang, Eun Seok

AU - Lee, Hyun Chul

AU - Cha, Bong Soo

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N2 - Background: The aim of this study was to investigate the effects of balsamic vinegar on β-cell dysfunction. Methods: In this study, 28-week-old Otsuka Long-Evans Tokushima Fatty (OLETF) rats were fed a normal chow diet or a highfat diet (HFD) and were provided with tap water or dilute balsamic vinegar for 4 weeks. Oral glucose tolerance tests and histopathological analyses were performed thereafter. Results: In rats fed both the both chow diet and the HFD, the rats given balsamic vinegar showed increased insulin staining in islets compared with tap water administered rats. Balsamic vinegar administration also increased β-cell ATP-binding cassette transporter subfamily A member 1 (ABCA1) expression in islets and decreased cholesterol levels. Conclusion: These findings provide the first evidence for an anti-diabetic effect of balsamic vinegar through improvement of β-cell function via increasing β-cell ABCA1 expression.

AB - Background: The aim of this study was to investigate the effects of balsamic vinegar on β-cell dysfunction. Methods: In this study, 28-week-old Otsuka Long-Evans Tokushima Fatty (OLETF) rats were fed a normal chow diet or a highfat diet (HFD) and were provided with tap water or dilute balsamic vinegar for 4 weeks. Oral glucose tolerance tests and histopathological analyses were performed thereafter. Results: In rats fed both the both chow diet and the HFD, the rats given balsamic vinegar showed increased insulin staining in islets compared with tap water administered rats. Balsamic vinegar administration also increased β-cell ATP-binding cassette transporter subfamily A member 1 (ABCA1) expression in islets and decreased cholesterol levels. Conclusion: These findings provide the first evidence for an anti-diabetic effect of balsamic vinegar through improvement of β-cell function via increasing β-cell ABCA1 expression.

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