BarleyNet: A Network-Based Functional Omics Analysis Server for Cultivated Barley, Hordeum vulgare L.

Sungho Lee, Tak Lee, Sunmo Yang, Insuk Lee

Research output: Contribution to journalArticlepeer-review

12 Citations (Scopus)


Cultivated barley (Hordeum vulgare L.) is one of the most produced cereal crops worldwide after maize, bread wheat, and rice. Barley is an important crop species not only as a food source, but also in plant genetics because it harbors numerous stress response alleles in its genome that can be exploited for crop engineering. However, the functional annotation of its genome is relatively poor compared with other major crops. Moreover, bioinformatics tools for system-wide analyses of omics data from barley are not yet available. We have thus developed BarleyNet, a co-functional network of 26,145 barley genes, along with a web server for network-based predictions ( We demonstrated that BarleyNet's prediction of biological processes is more accurate than that of an existing barley gene network. We implemented three complementary network-based algorithms for prioritizing genes or functional concepts to study genetic components of complex traits such as environmental stress responses: (i) a pathway-centric search for candidate genes of pathways or complex traits; (ii) a gene-centric search to infer novel functional concepts for genes; and (iii) a context-centric search for novel genes associated with stress response. We demonstrated the usefulness of these network analysis tools in the study of stress response using proteomics and transcriptomics data from barley leaves and roots upon drought or heat stresses. These results suggest that BarleyNet will facilitate our understanding of the underlying genetic components of complex traits in barley.

Original languageEnglish
Article number98
JournalFrontiers in Plant Science
Publication statusPublished - 2020 Feb 18

Bibliographical note

Funding Information:
This work was supported by the National Research Foundation of Korea (NRF) grant funded by the Korean Government (MSIT) (NRF-2018M3C9A5064709, NRF-2018R1A5A2025079) to IL.

Publisher Copyright:
© Copyright © 2020 Lee, Lee, Yang and Lee.

All Science Journal Classification (ASJC) codes

  • Plant Science


Dive into the research topics of 'BarleyNet: A Network-Based Functional Omics Analysis Server for Cultivated Barley, Hordeum vulgare L.'. Together they form a unique fingerprint.

Cite this