Barrier recovery after topically applied desoxymethasone ointment, vaseline and hydrobase on benzalkonium chloride-irritated hairless mice skin

Ku Ahn Sung Ku Ahn, Ho Choi Eung Ho Choi, J. Shaojun, Min Hwang Sang Min Hwang, Hun Lee Seung Hun Lee

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Background: Topical irritants disrupt the cutaneous permeability barrier through the removal of stratum corneum lipids. This perturbation of barrier integrity stimulates a variety of homeostatic repair responses that ultimately result in the normalization of barrier function. Object: To measure the effect of desoxymethasone ointment, vaseline and hydrobase on the barrier recovery of benzalkonium chloride (BKC) irritated skin. Materials and methods: The left flank skin of 2-3 month-old hairless mice was treated with BKC and then desoxymethasone ointment, vaseline and hydrobase were applied. Transepidermal water loss (TEWL) was checked after 0, 3, 6, 9, 12, 15, 18, 21 and 24 hours. Electron microscopic examination was performed after 3 and 24 hours after desoxymethasone, vaseline and hydrobase had been applied. Results: The recovery of TEWL was most prominantly observed in the desoxymethasone ointment treated group followed by vaseline and hydrobase. Electron microscopic examination using ruthenium tetroxide fixation revealed that secretion and numbers of lamellar bodies and complete formation of lipid bilayers were most prominent at desoxymethasone ointment and vaseline treated group. Conclusion: Desoxymethasone ointment, vaseline and hydrobase can be good agents in improving barrier recovery after exposure to irritant material.

Original languageEnglish
Pages (from-to)820-826
Number of pages7
JournalKorean Journal of Dermatology
Volume36
Issue number5
Publication statusPublished - 1998 Dec 1

Fingerprint

Desoximetasone
Benzalkonium Compounds
Petrolatum
Hairless Mouse
Ointments
Skin
Irritants
Electrons
Water
Lipid Bilayers
Cornea
Permeability
Lipids

All Science Journal Classification (ASJC) codes

  • Dermatology

Cite this

Sung Ku Ahn, Ku Ahn ; Eung Ho Choi, Ho Choi ; Shaojun, J. ; Sang Min Hwang, Min Hwang ; Seung Hun Lee, Hun Lee. / Barrier recovery after topically applied desoxymethasone ointment, vaseline and hydrobase on benzalkonium chloride-irritated hairless mice skin. In: Korean Journal of Dermatology. 1998 ; Vol. 36, No. 5. pp. 820-826.
@article{c569da430e084a568887a6cac9bae744,
title = "Barrier recovery after topically applied desoxymethasone ointment, vaseline and hydrobase on benzalkonium chloride-irritated hairless mice skin",
abstract = "Background: Topical irritants disrupt the cutaneous permeability barrier through the removal of stratum corneum lipids. This perturbation of barrier integrity stimulates a variety of homeostatic repair responses that ultimately result in the normalization of barrier function. Object: To measure the effect of desoxymethasone ointment, vaseline and hydrobase on the barrier recovery of benzalkonium chloride (BKC) irritated skin. Materials and methods: The left flank skin of 2-3 month-old hairless mice was treated with BKC and then desoxymethasone ointment, vaseline and hydrobase were applied. Transepidermal water loss (TEWL) was checked after 0, 3, 6, 9, 12, 15, 18, 21 and 24 hours. Electron microscopic examination was performed after 3 and 24 hours after desoxymethasone, vaseline and hydrobase had been applied. Results: The recovery of TEWL was most prominantly observed in the desoxymethasone ointment treated group followed by vaseline and hydrobase. Electron microscopic examination using ruthenium tetroxide fixation revealed that secretion and numbers of lamellar bodies and complete formation of lipid bilayers were most prominent at desoxymethasone ointment and vaseline treated group. Conclusion: Desoxymethasone ointment, vaseline and hydrobase can be good agents in improving barrier recovery after exposure to irritant material.",
author = "{Sung Ku Ahn}, {Ku Ahn} and {Eung Ho Choi}, {Ho Choi} and J. Shaojun and {Sang Min Hwang}, {Min Hwang} and {Seung Hun Lee}, {Hun Lee}",
year = "1998",
month = "12",
day = "1",
language = "English",
volume = "36",
pages = "820--826",
journal = "Korean Journal of Dermatology",
issn = "0494-4739",
publisher = "Korean Dermatological Association",
number = "5",

}

Barrier recovery after topically applied desoxymethasone ointment, vaseline and hydrobase on benzalkonium chloride-irritated hairless mice skin. / Sung Ku Ahn, Ku Ahn; Eung Ho Choi, Ho Choi; Shaojun, J.; Sang Min Hwang, Min Hwang; Seung Hun Lee, Hun Lee.

In: Korean Journal of Dermatology, Vol. 36, No. 5, 01.12.1998, p. 820-826.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Barrier recovery after topically applied desoxymethasone ointment, vaseline and hydrobase on benzalkonium chloride-irritated hairless mice skin

AU - Sung Ku Ahn, Ku Ahn

AU - Eung Ho Choi, Ho Choi

AU - Shaojun, J.

AU - Sang Min Hwang, Min Hwang

AU - Seung Hun Lee, Hun Lee

PY - 1998/12/1

Y1 - 1998/12/1

N2 - Background: Topical irritants disrupt the cutaneous permeability barrier through the removal of stratum corneum lipids. This perturbation of barrier integrity stimulates a variety of homeostatic repair responses that ultimately result in the normalization of barrier function. Object: To measure the effect of desoxymethasone ointment, vaseline and hydrobase on the barrier recovery of benzalkonium chloride (BKC) irritated skin. Materials and methods: The left flank skin of 2-3 month-old hairless mice was treated with BKC and then desoxymethasone ointment, vaseline and hydrobase were applied. Transepidermal water loss (TEWL) was checked after 0, 3, 6, 9, 12, 15, 18, 21 and 24 hours. Electron microscopic examination was performed after 3 and 24 hours after desoxymethasone, vaseline and hydrobase had been applied. Results: The recovery of TEWL was most prominantly observed in the desoxymethasone ointment treated group followed by vaseline and hydrobase. Electron microscopic examination using ruthenium tetroxide fixation revealed that secretion and numbers of lamellar bodies and complete formation of lipid bilayers were most prominent at desoxymethasone ointment and vaseline treated group. Conclusion: Desoxymethasone ointment, vaseline and hydrobase can be good agents in improving barrier recovery after exposure to irritant material.

AB - Background: Topical irritants disrupt the cutaneous permeability barrier through the removal of stratum corneum lipids. This perturbation of barrier integrity stimulates a variety of homeostatic repair responses that ultimately result in the normalization of barrier function. Object: To measure the effect of desoxymethasone ointment, vaseline and hydrobase on the barrier recovery of benzalkonium chloride (BKC) irritated skin. Materials and methods: The left flank skin of 2-3 month-old hairless mice was treated with BKC and then desoxymethasone ointment, vaseline and hydrobase were applied. Transepidermal water loss (TEWL) was checked after 0, 3, 6, 9, 12, 15, 18, 21 and 24 hours. Electron microscopic examination was performed after 3 and 24 hours after desoxymethasone, vaseline and hydrobase had been applied. Results: The recovery of TEWL was most prominantly observed in the desoxymethasone ointment treated group followed by vaseline and hydrobase. Electron microscopic examination using ruthenium tetroxide fixation revealed that secretion and numbers of lamellar bodies and complete formation of lipid bilayers were most prominent at desoxymethasone ointment and vaseline treated group. Conclusion: Desoxymethasone ointment, vaseline and hydrobase can be good agents in improving barrier recovery after exposure to irritant material.

UR - http://www.scopus.com/inward/record.url?scp=0032442052&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0032442052&partnerID=8YFLogxK

M3 - Article

AN - SCOPUS:0032442052

VL - 36

SP - 820

EP - 826

JO - Korean Journal of Dermatology

JF - Korean Journal of Dermatology

SN - 0494-4739

IS - 5

ER -