Basal forebrain cholinergic deficits reduce glucose metabolism and function of cholinergic and GABAergic systems in the cingulate cortex

Da Un Jeong, Jin Hwan Oh, Ji Eun Lee, Jihyeon Lee, Zang Hee Cho, JinWoo Chang, Won Seok Chang

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Purpose: Reduced brain glucose metabolism and basal forebrain cholinergic neuron degeneration are common features of Alzheimer’s disease and have been correlated with memory function. Although regions representing glucose hypometabolism in patients with Alzheimer’s disease are targets of cholinergic basal forebrain neurons, the interaction between cholinergic denervation and glucose hypometabolism is still unclear. The aim of the present study was to evaluate glucose metabolism changes caused by cholinergic deficits. Materials and Methods: We lesioned basal forebrain cholinergic neurons in rats using 192 immunoglobulin G-saporin. After 3 weeks, lesioned animals underwent water maze testing or were analyzed by 18F-2-fluoro-2-deoxyglucose positron emission tomography. Results: During water maze probe testing, performance of the lesioned group decreased with respect to time spent in the target quadrant and platform zone. Cingulate cortex glucose metabolism in the lesioned group decreased, compared with the normal group. Additionally, acetylcholinesterase activity and glutamate decarboxylase 65/67 expression declined in the cingulate cortex. Conclusion: Our results reveal that spatial memory impairment in animals with selective basal forebrain cholinergic neuron damage is associated with a functional decline in the GABAergic and cholinergic system associated with cingulate cortex glucose hypometabolism.

Original languageEnglish
Pages (from-to)165-172
Number of pages8
JournalYonsei medical journal
Volume57
Issue number1
DOIs
Publication statusPublished - 2016 Jan 1

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Gyrus Cinguli
Cholinergic Agents
Glucose
Cholinergic Neurons
Alzheimer Disease
Nerve Degeneration
Glutamate Decarboxylase
Water
Fluorodeoxyglucose F18
Denervation
Acetylcholinesterase
Positron-Emission Tomography
Basal Forebrain
Immunoglobulin G
Neurons
Brain

All Science Journal Classification (ASJC) codes

  • Medicine(all)

Cite this

Jeong, Da Un ; Oh, Jin Hwan ; Lee, Ji Eun ; Lee, Jihyeon ; Cho, Zang Hee ; Chang, JinWoo ; Chang, Won Seok. / Basal forebrain cholinergic deficits reduce glucose metabolism and function of cholinergic and GABAergic systems in the cingulate cortex. In: Yonsei medical journal. 2016 ; Vol. 57, No. 1. pp. 165-172.
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Basal forebrain cholinergic deficits reduce glucose metabolism and function of cholinergic and GABAergic systems in the cingulate cortex. / Jeong, Da Un; Oh, Jin Hwan; Lee, Ji Eun; Lee, Jihyeon; Cho, Zang Hee; Chang, JinWoo; Chang, Won Seok.

In: Yonsei medical journal, Vol. 57, No. 1, 01.01.2016, p. 165-172.

Research output: Contribution to journalArticle

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