Baseline characteristics of participants enrolled in the KoreaN cohort study for Outcomes in patients With Pediatric Chronic Kidney Disease (KNOW-Ped CKD)

Peong Gang Park; Hee Gyung Kang; Eujin Park; Yo Han Ahn; Hyun Jin Choi; Kyoung Hee Han; Seong Heon Kim; Heeyeon Cho; Keum Hwa Lee; Jae Il Shin; Min Hyun Cho; Joo Hoon Lee; Young Seo Park; Jayoun Kim; Il Soo Ha

doi:10.1007/s00467-021-05278-3

Baseline characteristics of participants enrolled in the KoreaN cohort study for Outcomes in patients With Pediatric Chronic Kidney Disease (KNOW-Ped CKD)

Peong Gang Park, Hee Gyung Kang, Eujin Park, Yo Han Ahn, Hyun Jin Choi, Kyoung Hee Han, Seong Heon Kim, Heeyeon Cho, Keum Hwa Lee, Jae Il Shin, Min Hyun Cho, Joo Hoon Lee, Young Seo Park, Jayoun Kim, Il Soo Ha

Department of Pediatrics

Research output: Contribution to journal › Article › peer-review

1 Citation (Scopus)

Abstract

Background: We developed the KoreaN cohort study for Outcomes in patients With Pediatric Chronic Kidney Disease (KNOW-Ped CKD) as a subcohort of KNOW-CKD to investigate the different characteristics of pediatric CKD between countries and races. Methods: Children aged younger than 18 years with stage 1 ~ 5 CKD were recruited at seven major pediatric nephrology centers in Korea. Blood and urine samples, as well as demographic and clinical data, were collected. From 2011 to 2016, 458 children were enrolled, and the baseline profiles of 437 children were analyzed. Results: The median age of the cohort was 10.9 years old, and 68.0% were males. The median estimated glomerular filtration rate was 53.1 mL/min/1.73 m². The most common etiology of CKD was congenital anomalies of the kidney and urinary tract (42.6%), followed by glomerulopathies (25.6%). Conclusion: We report a cross-sectional analysis of the overall baseline characteristics such as age, CKD stage, and underlying kidney disease of the KNOW-Ped CKD. The cohort will be longitudinally followed for ten years. Graphical abstract: “A higher resolution version of the Graphical abstract is available as Supplementary information.” [Figure not available: see fulltext.]

Original language	English
Pages (from-to)	3177-3187
Number of pages	11
Journal	Pediatric Nephrology
Volume	37
Issue number	12
DOIs	https://doi.org/10.1007/s00467-021-05278-3
Publication status	Published - 2022 Dec

Bibliographical note

Funding Information:
KNOW-PedCKD (trial registration:NCT02165878-ClinicalTrials.gov) was funded by grants 2011E3300300, 2012E3301100, 2013E3301600, 2013E3301601, 2013E3301602, 2016E3300200, 2016E3300201, 2016E3300202, 2019E320100, 2019-E3201-01, and 2019-E3201-02 awarded by the Research of Korea Centers for Disease Control and Prevention after peer review.

Publisher Copyright:
© 2022, The Author(s), under exclusive licence to International Pediatric Nephrology Association.

All Science Journal Classification (ASJC) codes

Pediatrics, Perinatology, and Child Health
Nephrology

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10.1007/s00467-021-05278-3

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Park, P. G., Kang, H. G., Park, E., Ahn, Y. H., Choi, H. J., Han, K. H., Kim, S. H., Cho, H., Lee, K. H., Shin, J. I., Cho, M. H., Lee, J. H., Park, Y. S., Kim, J., & Ha, I. S. (2022). Baseline characteristics of participants enrolled in the KoreaN cohort study for Outcomes in patients With Pediatric Chronic Kidney Disease (KNOW-Ped CKD). Pediatric Nephrology, 37(12), 3177-3187. https://doi.org/10.1007/s00467-021-05278-3

@article{05e1c2d8742043a6873b90d5c2a603c2,

title = "Baseline characteristics of participants enrolled in the KoreaN cohort study for Outcomes in patients With Pediatric Chronic Kidney Disease (KNOW-Ped CKD)",

abstract = "Background: We developed the KoreaN cohort study for Outcomes in patients With Pediatric Chronic Kidney Disease (KNOW-Ped CKD) as a subcohort of KNOW-CKD to investigate the different characteristics of pediatric CKD between countries and races. Methods: Children aged younger than 18 years with stage 1 ~ 5 CKD were recruited at seven major pediatric nephrology centers in Korea. Blood and urine samples, as well as demographic and clinical data, were collected. From 2011 to 2016, 458 children were enrolled, and the baseline profiles of 437 children were analyzed. Results: The median age of the cohort was 10.9 years old, and 68.0% were males. The median estimated glomerular filtration rate was 53.1 mL/min/1.73 m2. The most common etiology of CKD was congenital anomalies of the kidney and urinary tract (42.6%), followed by glomerulopathies (25.6%). Conclusion: We report a cross-sectional analysis of the overall baseline characteristics such as age, CKD stage, and underlying kidney disease of the KNOW-Ped CKD. The cohort will be longitudinally followed for ten years. Graphical abstract: “A higher resolution version of the Graphical abstract is available as Supplementary information.” [Figure not available: see fulltext.]",

author = "Park, {Peong Gang} and Kang, {Hee Gyung} and Eujin Park and Ahn, {Yo Han} and Choi, {Hyun Jin} and Han, {Kyoung Hee} and Kim, {Seong Heon} and Heeyeon Cho and Lee, {Keum Hwa} and Shin, {Jae Il} and Cho, {Min Hyun} and Lee, {Joo Hoon} and Park, {Young Seo} and Jayoun Kim and Ha, {Il Soo}",

note = "Funding Information: KNOW-PedCKD (trial registration:NCT02165878-ClinicalTrials.gov) was funded by grants 2011E3300300, 2012E3301100, 2013E3301600, 2013E3301601, 2013E3301602, 2016E3300200, 2016E3300201, 2016E3300202, 2019E320100, 2019-E3201-01, and 2019-E3201-02 awarded by the Research of Korea Centers for Disease Control and Prevention after peer review. Publisher Copyright: {\textcopyright} 2022, The Author(s), under exclusive licence to International Pediatric Nephrology Association.",

year = "2022",

month = dec,

doi = "10.1007/s00467-021-05278-3",

language = "English",

volume = "37",

pages = "3177--3187",

journal = "Pediatric Nephrology",

issn = "0931-041X",

publisher = "Springer Verlag",

number = "12",

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Park, PG, Kang, HG, Park, E, Ahn, YH, Choi, HJ, Han, KH, Kim, SH, Cho, H, Lee, KH, Shin, JI, Cho, MH, Lee, JH, Park, YS, Kim, J & Ha, IS 2022, 'Baseline characteristics of participants enrolled in the KoreaN cohort study for Outcomes in patients With Pediatric Chronic Kidney Disease (KNOW-Ped CKD)', Pediatric Nephrology, vol. 37, no. 12, pp. 3177-3187. https://doi.org/10.1007/s00467-021-05278-3

TY - JOUR

T1 - Baseline characteristics of participants enrolled in the KoreaN cohort study for Outcomes in patients With Pediatric Chronic Kidney Disease (KNOW-Ped CKD)

AU - Park, Peong Gang

AU - Kang, Hee Gyung

AU - Park, Eujin

AU - Ahn, Yo Han

AU - Choi, Hyun Jin

AU - Han, Kyoung Hee

AU - Kim, Seong Heon

AU - Cho, Heeyeon

AU - Lee, Keum Hwa

AU - Shin, Jae Il

AU - Cho, Min Hyun

AU - Lee, Joo Hoon

AU - Park, Young Seo

AU - Kim, Jayoun

AU - Ha, Il Soo

N1 - Funding Information: KNOW-PedCKD (trial registration:NCT02165878-ClinicalTrials.gov) was funded by grants 2011E3300300, 2012E3301100, 2013E3301600, 2013E3301601, 2013E3301602, 2016E3300200, 2016E3300201, 2016E3300202, 2019E320100, 2019-E3201-01, and 2019-E3201-02 awarded by the Research of Korea Centers for Disease Control and Prevention after peer review. Publisher Copyright: © 2022, The Author(s), under exclusive licence to International Pediatric Nephrology Association.

PY - 2022/12

Y1 - 2022/12

N2 - Background: We developed the KoreaN cohort study for Outcomes in patients With Pediatric Chronic Kidney Disease (KNOW-Ped CKD) as a subcohort of KNOW-CKD to investigate the different characteristics of pediatric CKD between countries and races. Methods: Children aged younger than 18 years with stage 1 ~ 5 CKD were recruited at seven major pediatric nephrology centers in Korea. Blood and urine samples, as well as demographic and clinical data, were collected. From 2011 to 2016, 458 children were enrolled, and the baseline profiles of 437 children were analyzed. Results: The median age of the cohort was 10.9 years old, and 68.0% were males. The median estimated glomerular filtration rate was 53.1 mL/min/1.73 m2. The most common etiology of CKD was congenital anomalies of the kidney and urinary tract (42.6%), followed by glomerulopathies (25.6%). Conclusion: We report a cross-sectional analysis of the overall baseline characteristics such as age, CKD stage, and underlying kidney disease of the KNOW-Ped CKD. The cohort will be longitudinally followed for ten years. Graphical abstract: “A higher resolution version of the Graphical abstract is available as Supplementary information.” [Figure not available: see fulltext.]

AB - Background: We developed the KoreaN cohort study for Outcomes in patients With Pediatric Chronic Kidney Disease (KNOW-Ped CKD) as a subcohort of KNOW-CKD to investigate the different characteristics of pediatric CKD between countries and races. Methods: Children aged younger than 18 years with stage 1 ~ 5 CKD were recruited at seven major pediatric nephrology centers in Korea. Blood and urine samples, as well as demographic and clinical data, were collected. From 2011 to 2016, 458 children were enrolled, and the baseline profiles of 437 children were analyzed. Results: The median age of the cohort was 10.9 years old, and 68.0% were males. The median estimated glomerular filtration rate was 53.1 mL/min/1.73 m2. The most common etiology of CKD was congenital anomalies of the kidney and urinary tract (42.6%), followed by glomerulopathies (25.6%). Conclusion: We report a cross-sectional analysis of the overall baseline characteristics such as age, CKD stage, and underlying kidney disease of the KNOW-Ped CKD. The cohort will be longitudinally followed for ten years. Graphical abstract: “A higher resolution version of the Graphical abstract is available as Supplementary information.” [Figure not available: see fulltext.]

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U2 - 10.1007/s00467-021-05278-3

DO - 10.1007/s00467-021-05278-3

M3 - Article

C2 - 35277754

AN - SCOPUS:85126085578

SN - 0931-041X

VL - 37

SP - 3177

EP - 3187

JO - Pediatric Nephrology

JF - Pediatric Nephrology

IS - 12

ER -

Baseline characteristics of participants enrolled in the KoreaN cohort study for Outcomes in patients With Pediatric Chronic Kidney Disease (KNOW-Ped CKD)

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