Baseline Chloride Levels are Associated with the Incidence of Contrast-Associated Acute Kidney Injury

Hyung Jung Oh, Sungwon Kim, Jung Tak Park, Sang Joon Kim, Seung Hyeok Han, Tae Hyun Yoo, Dong Ryeol Ryu, Shin Wook Kang, Yong Eun Chung

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Abstract

Although hypo-And hyperchloremia have been associated with worsening renal outcomes, there has been no study that correlates hypo-And hyperchloremia and the incidence of contrast-Associated acute kidney injury (CA-AKI). A total of 13,088 patients with less than 2.0 mg/dL of serum creatinine (Cr) who underwent contrast-enhanced abdominal CT (CECT) were included. Patients were divided into 3 groups based on Cl (the hypo-, normo-And hyperchloremia groups). Patients were also classified by baseline Cr (<1.2; the 'Normal Cr group' and 1.2-2.0 mg/dL; the 'Slightly increased Cr group'). Multivariate logistic regression analysis was used to reveal the association between Cl and CA-AKI. Among patients, 2,525 (19.3%) and 241 (1.8%) patients were classified in the hypo-And hyperchloremia group. The incidence of CA-AKI was significantly lower in the normochloremia group (4.0%) compared to the hypo-(5.4%) and hyperchloremia groups (9.5%). On multivariate logistic regression, hypochloremia was significantly associated with the incidence of CA-AKI compared with normochloremia (1.382, P = 0.002). Moreover, hypochloremia was still significantly associated with the incidence of CA-AKI in 'Normal Cr group' compared with normochloremia (1.314, P = 0.015), while hyperchloremia did not show significant association with CA-AKI incidence. In conclusion, hypochloremia might be associated with the incidence of CA-AKI even in patients who have normal-range Cr levels.

Original languageEnglish
Article number7431
JournalScientific reports
Volume7
Issue number1
DOIs
Publication statusPublished - 2017 Dec 1

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Acute Kidney Injury
Chlorides
Creatinine
Incidence
Logistic Models
Reference Values
Regression Analysis
Kidney
Serum

All Science Journal Classification (ASJC) codes

  • General

Cite this

Oh, Hyung Jung ; Kim, Sungwon ; Park, Jung Tak ; Kim, Sang Joon ; Han, Seung Hyeok ; Yoo, Tae Hyun ; Ryu, Dong Ryeol ; Kang, Shin Wook ; Chung, Yong Eun. / Baseline Chloride Levels are Associated with the Incidence of Contrast-Associated Acute Kidney Injury. In: Scientific reports. 2017 ; Vol. 7, No. 1.
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title = "Baseline Chloride Levels are Associated with the Incidence of Contrast-Associated Acute Kidney Injury",
abstract = "Although hypo-And hyperchloremia have been associated with worsening renal outcomes, there has been no study that correlates hypo-And hyperchloremia and the incidence of contrast-Associated acute kidney injury (CA-AKI). A total of 13,088 patients with less than 2.0 mg/dL of serum creatinine (Cr) who underwent contrast-enhanced abdominal CT (CECT) were included. Patients were divided into 3 groups based on Cl (the hypo-, normo-And hyperchloremia groups). Patients were also classified by baseline Cr (<1.2; the 'Normal Cr group' and 1.2-2.0 mg/dL; the 'Slightly increased Cr group'). Multivariate logistic regression analysis was used to reveal the association between Cl and CA-AKI. Among patients, 2,525 (19.3{\%}) and 241 (1.8{\%}) patients were classified in the hypo-And hyperchloremia group. The incidence of CA-AKI was significantly lower in the normochloremia group (4.0{\%}) compared to the hypo-(5.4{\%}) and hyperchloremia groups (9.5{\%}). On multivariate logistic regression, hypochloremia was significantly associated with the incidence of CA-AKI compared with normochloremia (1.382, P = 0.002). Moreover, hypochloremia was still significantly associated with the incidence of CA-AKI in 'Normal Cr group' compared with normochloremia (1.314, P = 0.015), while hyperchloremia did not show significant association with CA-AKI incidence. In conclusion, hypochloremia might be associated with the incidence of CA-AKI even in patients who have normal-range Cr levels.",
author = "Oh, {Hyung Jung} and Sungwon Kim and Park, {Jung Tak} and Kim, {Sang Joon} and Han, {Seung Hyeok} and Yoo, {Tae Hyun} and Ryu, {Dong Ryeol} and Kang, {Shin Wook} and Chung, {Yong Eun}",
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Baseline Chloride Levels are Associated with the Incidence of Contrast-Associated Acute Kidney Injury. / Oh, Hyung Jung; Kim, Sungwon; Park, Jung Tak; Kim, Sang Joon; Han, Seung Hyeok; Yoo, Tae Hyun; Ryu, Dong Ryeol; Kang, Shin Wook; Chung, Yong Eun.

In: Scientific reports, Vol. 7, No. 1, 7431, 01.12.2017.

Research output: Contribution to journalArticle

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AU - Oh, Hyung Jung

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AB - Although hypo-And hyperchloremia have been associated with worsening renal outcomes, there has been no study that correlates hypo-And hyperchloremia and the incidence of contrast-Associated acute kidney injury (CA-AKI). A total of 13,088 patients with less than 2.0 mg/dL of serum creatinine (Cr) who underwent contrast-enhanced abdominal CT (CECT) were included. Patients were divided into 3 groups based on Cl (the hypo-, normo-And hyperchloremia groups). Patients were also classified by baseline Cr (<1.2; the 'Normal Cr group' and 1.2-2.0 mg/dL; the 'Slightly increased Cr group'). Multivariate logistic regression analysis was used to reveal the association between Cl and CA-AKI. Among patients, 2,525 (19.3%) and 241 (1.8%) patients were classified in the hypo-And hyperchloremia group. The incidence of CA-AKI was significantly lower in the normochloremia group (4.0%) compared to the hypo-(5.4%) and hyperchloremia groups (9.5%). On multivariate logistic regression, hypochloremia was significantly associated with the incidence of CA-AKI compared with normochloremia (1.382, P = 0.002). Moreover, hypochloremia was still significantly associated with the incidence of CA-AKI in 'Normal Cr group' compared with normochloremia (1.314, P = 0.015), while hyperchloremia did not show significant association with CA-AKI incidence. In conclusion, hypochloremia might be associated with the incidence of CA-AKI even in patients who have normal-range Cr levels.

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