BCl3-promoted synthesis of benzofurans

Ikyon Kim, Sei Hee Lee, Sunkyung Lee

Research output: Contribution to journalArticlepeer-review

37 Citations (Scopus)

Abstract

Lewis acidic nature of boron trichloride (BCl3) to coordinate to the carbonyl functionality was exploited for the synthesis of benzofurans via dehydrative cyclization. This mild and efficient procedure allowed for facile access to a number of highly substituted benzofurans in a regioselective manner. The structural requirement for the successful cyclodehydration was examined in the cases, where competitive demethylation could occur.

Original languageEnglish
Pages (from-to)6579-6584
Number of pages6
JournalTetrahedron Letters
Volume49
Issue number46
DOIs
Publication statusPublished - 2008 Nov 10

Bibliographical note

Funding Information:
We thank the Center for Biological Modulators and Korea Research Institute of Chemical Technology for supporting this work.

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

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