Behavioural and metabolic risk factors for mortality from colon and rectum cancer: Analysis of data from the Asia-Pacific Cohort Studies collaboration

David Stewart Morrison, Christine Louise Parr, Tai Hing Lam, Hirotsugu Ueshima, Hyeon Chang Kim, Sun Ha Jee, Yoshitaka Murakami, Graham Giles, Xianghua Fang, Federica Barzi, George David Batty, Rachel Rita Huxley, Mark Woodward

Research output: Contribution to journalArticle

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Abstract

Background: Colorectal cancer has several modifiable behavioural risk factors but their relationship to the risk of colon and rectum cancer separately and between countries with high and low incidence is not clear. Methods: Data from participants in the Asia Pacific Cohort Studies Collaboration (APCSC) were used to estimate mortality from colon (International Classification of Diseases, revision 9 (ICD-9) 153, ICD-10 C18) and rectum (ICD-9 154, ICD-10 C19-20) cancers. Data on age, body mass index (BMI), serum cholesterol, height, smoking, physical activity, alcohol and diabetes mellitus were entered into Cox proportional hazards models. Results: 600,427 adults contributed 4,281,239 person-years follow-up. The mean ages (SD) for Asian and Australia/New Zealand cohorts were 44.0 (9.5) and 53.4 (14.5) years, respectively. 455 colon and 158 rectum cancer deaths were observed. Increasing age, BMI and attained adult height were associated with increased hazards of death from colorectal cancer, and physical activity was associated with a reduced hazard. After multiple adjustment, any physical activity was associated with a 28% lower hazard of colon cancer mortality (HR 0.72, 95%CI 0.53-0.96) and lower rectum cancer mortality (HR 0.75, 95%CI 0.45-1.27). A 2cm increase in height increased colon and all colorectal cancer mortality by 7% and 6% respectively. Conclusions: Physical inactivity and greater BMI are modifiable risk factors for colon cancer in both Western and Asian populations. Further efforts are needed to promote physical activity and reduce obesity while biological research is needed to understand the mechanisms by which they act to cause cancer mortality.

Original languageEnglish
Pages (from-to)1083-1087
Number of pages5
JournalAsian Pacific Journal of Cancer Prevention
Volume14
Issue number2
DOIs
Publication statusPublished - 2013

Fingerprint

Rectal Neoplasms
Colonic Neoplasms
International Classification of Diseases
Cohort Studies
Mortality
Colorectal Neoplasms
Colon
Body Mass Index
Social Adjustment
New Zealand
Proportional Hazards Models
Rectum
Neoplasms
Diabetes Mellitus
Obesity
Smoking
Cholesterol
Alcohols
Incidence
Serum

All Science Journal Classification (ASJC) codes

  • Epidemiology
  • Oncology
  • Public Health, Environmental and Occupational Health
  • Cancer Research

Cite this

Morrison, David Stewart ; Parr, Christine Louise ; Lam, Tai Hing ; Ueshima, Hirotsugu ; Kim, Hyeon Chang ; Jee, Sun Ha ; Murakami, Yoshitaka ; Giles, Graham ; Fang, Xianghua ; Barzi, Federica ; Batty, George David ; Huxley, Rachel Rita ; Woodward, Mark. / Behavioural and metabolic risk factors for mortality from colon and rectum cancer : Analysis of data from the Asia-Pacific Cohort Studies collaboration. In: Asian Pacific Journal of Cancer Prevention. 2013 ; Vol. 14, No. 2. pp. 1083-1087.
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title = "Behavioural and metabolic risk factors for mortality from colon and rectum cancer: Analysis of data from the Asia-Pacific Cohort Studies collaboration",
abstract = "Background: Colorectal cancer has several modifiable behavioural risk factors but their relationship to the risk of colon and rectum cancer separately and between countries with high and low incidence is not clear. Methods: Data from participants in the Asia Pacific Cohort Studies Collaboration (APCSC) were used to estimate mortality from colon (International Classification of Diseases, revision 9 (ICD-9) 153, ICD-10 C18) and rectum (ICD-9 154, ICD-10 C19-20) cancers. Data on age, body mass index (BMI), serum cholesterol, height, smoking, physical activity, alcohol and diabetes mellitus were entered into Cox proportional hazards models. Results: 600,427 adults contributed 4,281,239 person-years follow-up. The mean ages (SD) for Asian and Australia/New Zealand cohorts were 44.0 (9.5) and 53.4 (14.5) years, respectively. 455 colon and 158 rectum cancer deaths were observed. Increasing age, BMI and attained adult height were associated with increased hazards of death from colorectal cancer, and physical activity was associated with a reduced hazard. After multiple adjustment, any physical activity was associated with a 28{\%} lower hazard of colon cancer mortality (HR 0.72, 95{\%}CI 0.53-0.96) and lower rectum cancer mortality (HR 0.75, 95{\%}CI 0.45-1.27). A 2cm increase in height increased colon and all colorectal cancer mortality by 7{\%} and 6{\%} respectively. Conclusions: Physical inactivity and greater BMI are modifiable risk factors for colon cancer in both Western and Asian populations. Further efforts are needed to promote physical activity and reduce obesity while biological research is needed to understand the mechanisms by which they act to cause cancer mortality.",
author = "Morrison, {David Stewart} and Parr, {Christine Louise} and Lam, {Tai Hing} and Hirotsugu Ueshima and Kim, {Hyeon Chang} and Jee, {Sun Ha} and Yoshitaka Murakami and Graham Giles and Xianghua Fang and Federica Barzi and Batty, {George David} and Huxley, {Rachel Rita} and Mark Woodward",
year = "2013",
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language = "English",
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Morrison, DS, Parr, CL, Lam, TH, Ueshima, H, Kim, HC, Jee, SH, Murakami, Y, Giles, G, Fang, X, Barzi, F, Batty, GD, Huxley, RR & Woodward, M 2013, 'Behavioural and metabolic risk factors for mortality from colon and rectum cancer: Analysis of data from the Asia-Pacific Cohort Studies collaboration', Asian Pacific Journal of Cancer Prevention, vol. 14, no. 2, pp. 1083-1087. https://doi.org/10.7314/APJCP.2013.14.2.1083

Behavioural and metabolic risk factors for mortality from colon and rectum cancer : Analysis of data from the Asia-Pacific Cohort Studies collaboration. / Morrison, David Stewart; Parr, Christine Louise; Lam, Tai Hing; Ueshima, Hirotsugu; Kim, Hyeon Chang; Jee, Sun Ha; Murakami, Yoshitaka; Giles, Graham; Fang, Xianghua; Barzi, Federica; Batty, George David; Huxley, Rachel Rita; Woodward, Mark.

In: Asian Pacific Journal of Cancer Prevention, Vol. 14, No. 2, 2013, p. 1083-1087.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Behavioural and metabolic risk factors for mortality from colon and rectum cancer

T2 - Analysis of data from the Asia-Pacific Cohort Studies collaboration

AU - Morrison, David Stewart

AU - Parr, Christine Louise

AU - Lam, Tai Hing

AU - Ueshima, Hirotsugu

AU - Kim, Hyeon Chang

AU - Jee, Sun Ha

AU - Murakami, Yoshitaka

AU - Giles, Graham

AU - Fang, Xianghua

AU - Barzi, Federica

AU - Batty, George David

AU - Huxley, Rachel Rita

AU - Woodward, Mark

PY - 2013

Y1 - 2013

N2 - Background: Colorectal cancer has several modifiable behavioural risk factors but their relationship to the risk of colon and rectum cancer separately and between countries with high and low incidence is not clear. Methods: Data from participants in the Asia Pacific Cohort Studies Collaboration (APCSC) were used to estimate mortality from colon (International Classification of Diseases, revision 9 (ICD-9) 153, ICD-10 C18) and rectum (ICD-9 154, ICD-10 C19-20) cancers. Data on age, body mass index (BMI), serum cholesterol, height, smoking, physical activity, alcohol and diabetes mellitus were entered into Cox proportional hazards models. Results: 600,427 adults contributed 4,281,239 person-years follow-up. The mean ages (SD) for Asian and Australia/New Zealand cohorts were 44.0 (9.5) and 53.4 (14.5) years, respectively. 455 colon and 158 rectum cancer deaths were observed. Increasing age, BMI and attained adult height were associated with increased hazards of death from colorectal cancer, and physical activity was associated with a reduced hazard. After multiple adjustment, any physical activity was associated with a 28% lower hazard of colon cancer mortality (HR 0.72, 95%CI 0.53-0.96) and lower rectum cancer mortality (HR 0.75, 95%CI 0.45-1.27). A 2cm increase in height increased colon and all colorectal cancer mortality by 7% and 6% respectively. Conclusions: Physical inactivity and greater BMI are modifiable risk factors for colon cancer in both Western and Asian populations. Further efforts are needed to promote physical activity and reduce obesity while biological research is needed to understand the mechanisms by which they act to cause cancer mortality.

AB - Background: Colorectal cancer has several modifiable behavioural risk factors but their relationship to the risk of colon and rectum cancer separately and between countries with high and low incidence is not clear. Methods: Data from participants in the Asia Pacific Cohort Studies Collaboration (APCSC) were used to estimate mortality from colon (International Classification of Diseases, revision 9 (ICD-9) 153, ICD-10 C18) and rectum (ICD-9 154, ICD-10 C19-20) cancers. Data on age, body mass index (BMI), serum cholesterol, height, smoking, physical activity, alcohol and diabetes mellitus were entered into Cox proportional hazards models. Results: 600,427 adults contributed 4,281,239 person-years follow-up. The mean ages (SD) for Asian and Australia/New Zealand cohorts were 44.0 (9.5) and 53.4 (14.5) years, respectively. 455 colon and 158 rectum cancer deaths were observed. Increasing age, BMI and attained adult height were associated with increased hazards of death from colorectal cancer, and physical activity was associated with a reduced hazard. After multiple adjustment, any physical activity was associated with a 28% lower hazard of colon cancer mortality (HR 0.72, 95%CI 0.53-0.96) and lower rectum cancer mortality (HR 0.75, 95%CI 0.45-1.27). A 2cm increase in height increased colon and all colorectal cancer mortality by 7% and 6% respectively. Conclusions: Physical inactivity and greater BMI are modifiable risk factors for colon cancer in both Western and Asian populations. Further efforts are needed to promote physical activity and reduce obesity while biological research is needed to understand the mechanisms by which they act to cause cancer mortality.

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