Beneficial effect of intravenous magnesium during endoscopic submucosal dissection for gastric neoplasm

Ji Eun Kim, Cheung Soo Shin, Young Chan Lee, Hye Sun Lee, Mingi Ban, So Yeon Kim

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Background: Endoscopic submucosal dissection (ESD) has been revealed as an effective treatment of early gastric neoplasm and should be performed under sedation with adequate pain control. Magnesium sulfate has analgesic, sedative, and sympatholytic properties. This study examined the effects of intravenous magnesium 50 mg/kg administered before ESD for gastric neoplasm on analgesic and sedative consumptions during ESD and pain after ESD. Methods: In this randomized, double-blind, and prospective study, patients undergoing ESD randomly received either intravenous magnesium sulfate 50 mg/kg (magnesium group n = 30) or the same volume of normal saline (control group n = 30) over 10 min before the start of sedation. Fentanyl consumption during ESD was the primary end point. Hemodynamics was recorded during the procedure, and abdominal pain was evaluated at 30 min, 6 h, and 24 h after ESD. Results: During ESD, fentanyl consumption was 24 % less in the magnesium group than in the control group (96 ± 27 vs. 126 ± 41 μg, mean ± SD; p = 0.002), although there was no significant difference in propofol consumption (p = 0.317). In addition, magnesium attenuated the elevation of mean blood pressure at the time of epinephrine submucosal injection (p = 0.038) and 5 min after submucosal dissection (p = 0.004). Less patients of the magnesium group compared to the control group requested for additional analgesics in the recovery room (14 vs. 38 %, p = 0.043), and the intensity of abdominal pain was lower at 30 min after ESD in the magnesium group (p = 0.034). Conclusions: A single-dose intravenous administration of magnesium 50 mg/kg before sedation reduced analgesic requirements both during and after ESD for gastric neoplasm without adverse effects. In addition, magnesium contributed to stable hemodynamics throughout the procedure.

Original languageEnglish
Pages (from-to)3795-3802
Number of pages8
JournalSurgical endoscopy
Volume29
Issue number12
DOIs
Publication statusPublished - 2015 Dec 1

Fingerprint

Magnesium
Stomach Neoplasms
Analgesics
Magnesium Sulfate
Fentanyl
Hypnotics and Sedatives
Control Groups
Abdominal Pain
Hemodynamics
Endoscopic Mucosal Resection
Sympatholytics
Recovery Room
Pain
Propofol
Double-Blind Method
Intravenous Administration
Epinephrine
Dissection
Prospective Studies
Blood Pressure

All Science Journal Classification (ASJC) codes

  • Surgery

Cite this

Kim, Ji Eun ; Shin, Cheung Soo ; Lee, Young Chan ; Lee, Hye Sun ; Ban, Mingi ; Kim, So Yeon. / Beneficial effect of intravenous magnesium during endoscopic submucosal dissection for gastric neoplasm. In: Surgical endoscopy. 2015 ; Vol. 29, No. 12. pp. 3795-3802.
@article{fb6b4be092af49d0a0ded9f066c7b7d1,
title = "Beneficial effect of intravenous magnesium during endoscopic submucosal dissection for gastric neoplasm",
abstract = "Background: Endoscopic submucosal dissection (ESD) has been revealed as an effective treatment of early gastric neoplasm and should be performed under sedation with adequate pain control. Magnesium sulfate has analgesic, sedative, and sympatholytic properties. This study examined the effects of intravenous magnesium 50 mg/kg administered before ESD for gastric neoplasm on analgesic and sedative consumptions during ESD and pain after ESD. Methods: In this randomized, double-blind, and prospective study, patients undergoing ESD randomly received either intravenous magnesium sulfate 50 mg/kg (magnesium group n = 30) or the same volume of normal saline (control group n = 30) over 10 min before the start of sedation. Fentanyl consumption during ESD was the primary end point. Hemodynamics was recorded during the procedure, and abdominal pain was evaluated at 30 min, 6 h, and 24 h after ESD. Results: During ESD, fentanyl consumption was 24 {\%} less in the magnesium group than in the control group (96 ± 27 vs. 126 ± 41 μg, mean ± SD; p = 0.002), although there was no significant difference in propofol consumption (p = 0.317). In addition, magnesium attenuated the elevation of mean blood pressure at the time of epinephrine submucosal injection (p = 0.038) and 5 min after submucosal dissection (p = 0.004). Less patients of the magnesium group compared to the control group requested for additional analgesics in the recovery room (14 vs. 38 {\%}, p = 0.043), and the intensity of abdominal pain was lower at 30 min after ESD in the magnesium group (p = 0.034). Conclusions: A single-dose intravenous administration of magnesium 50 mg/kg before sedation reduced analgesic requirements both during and after ESD for gastric neoplasm without adverse effects. In addition, magnesium contributed to stable hemodynamics throughout the procedure.",
author = "Kim, {Ji Eun} and Shin, {Cheung Soo} and Lee, {Young Chan} and Lee, {Hye Sun} and Mingi Ban and Kim, {So Yeon}",
year = "2015",
month = "12",
day = "1",
doi = "10.1007/s00464-015-4514-1",
language = "English",
volume = "29",
pages = "3795--3802",
journal = "Surgical Endoscopy",
issn = "0930-2794",
publisher = "Springer New York",
number = "12",

}

Beneficial effect of intravenous magnesium during endoscopic submucosal dissection for gastric neoplasm. / Kim, Ji Eun; Shin, Cheung Soo; Lee, Young Chan; Lee, Hye Sun; Ban, Mingi; Kim, So Yeon.

In: Surgical endoscopy, Vol. 29, No. 12, 01.12.2015, p. 3795-3802.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Beneficial effect of intravenous magnesium during endoscopic submucosal dissection for gastric neoplasm

AU - Kim, Ji Eun

AU - Shin, Cheung Soo

AU - Lee, Young Chan

AU - Lee, Hye Sun

AU - Ban, Mingi

AU - Kim, So Yeon

PY - 2015/12/1

Y1 - 2015/12/1

N2 - Background: Endoscopic submucosal dissection (ESD) has been revealed as an effective treatment of early gastric neoplasm and should be performed under sedation with adequate pain control. Magnesium sulfate has analgesic, sedative, and sympatholytic properties. This study examined the effects of intravenous magnesium 50 mg/kg administered before ESD for gastric neoplasm on analgesic and sedative consumptions during ESD and pain after ESD. Methods: In this randomized, double-blind, and prospective study, patients undergoing ESD randomly received either intravenous magnesium sulfate 50 mg/kg (magnesium group n = 30) or the same volume of normal saline (control group n = 30) over 10 min before the start of sedation. Fentanyl consumption during ESD was the primary end point. Hemodynamics was recorded during the procedure, and abdominal pain was evaluated at 30 min, 6 h, and 24 h after ESD. Results: During ESD, fentanyl consumption was 24 % less in the magnesium group than in the control group (96 ± 27 vs. 126 ± 41 μg, mean ± SD; p = 0.002), although there was no significant difference in propofol consumption (p = 0.317). In addition, magnesium attenuated the elevation of mean blood pressure at the time of epinephrine submucosal injection (p = 0.038) and 5 min after submucosal dissection (p = 0.004). Less patients of the magnesium group compared to the control group requested for additional analgesics in the recovery room (14 vs. 38 %, p = 0.043), and the intensity of abdominal pain was lower at 30 min after ESD in the magnesium group (p = 0.034). Conclusions: A single-dose intravenous administration of magnesium 50 mg/kg before sedation reduced analgesic requirements both during and after ESD for gastric neoplasm without adverse effects. In addition, magnesium contributed to stable hemodynamics throughout the procedure.

AB - Background: Endoscopic submucosal dissection (ESD) has been revealed as an effective treatment of early gastric neoplasm and should be performed under sedation with adequate pain control. Magnesium sulfate has analgesic, sedative, and sympatholytic properties. This study examined the effects of intravenous magnesium 50 mg/kg administered before ESD for gastric neoplasm on analgesic and sedative consumptions during ESD and pain after ESD. Methods: In this randomized, double-blind, and prospective study, patients undergoing ESD randomly received either intravenous magnesium sulfate 50 mg/kg (magnesium group n = 30) or the same volume of normal saline (control group n = 30) over 10 min before the start of sedation. Fentanyl consumption during ESD was the primary end point. Hemodynamics was recorded during the procedure, and abdominal pain was evaluated at 30 min, 6 h, and 24 h after ESD. Results: During ESD, fentanyl consumption was 24 % less in the magnesium group than in the control group (96 ± 27 vs. 126 ± 41 μg, mean ± SD; p = 0.002), although there was no significant difference in propofol consumption (p = 0.317). In addition, magnesium attenuated the elevation of mean blood pressure at the time of epinephrine submucosal injection (p = 0.038) and 5 min after submucosal dissection (p = 0.004). Less patients of the magnesium group compared to the control group requested for additional analgesics in the recovery room (14 vs. 38 %, p = 0.043), and the intensity of abdominal pain was lower at 30 min after ESD in the magnesium group (p = 0.034). Conclusions: A single-dose intravenous administration of magnesium 50 mg/kg before sedation reduced analgesic requirements both during and after ESD for gastric neoplasm without adverse effects. In addition, magnesium contributed to stable hemodynamics throughout the procedure.

UR - http://www.scopus.com/inward/record.url?scp=84947489714&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84947489714&partnerID=8YFLogxK

U2 - 10.1007/s00464-015-4514-1

DO - 10.1007/s00464-015-4514-1

M3 - Article

C2 - 26335078

AN - SCOPUS:84947489714

VL - 29

SP - 3795

EP - 3802

JO - Surgical Endoscopy

JF - Surgical Endoscopy

SN - 0930-2794

IS - 12

ER -